Cruises to Panama City
51 live cruises call at Panama City — 10 to 108 nights, departing 12 ports, across 7 lines. A NestCruise advisor narrows them to the one that fits.
CaribbeanEmerald Cruises
Discover the Secrets of Panama and Costa Rica
Aboard Emerald Azzurra
Bridgetown → Port Elizabeth, Bequia → Mayreau Island → Kralendijk +15 more
18 nights · 3 departures
Port-rich · 19 ports
AmericasOceania Cruises
Classic Canal & Tropics
Aboard Oceania Marina
Panama City → Panama Canal Transit → Cartagena → At Sea +5 more
10 nights · 2 departures
Port-rich · 9 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Costa Rica
Aboard Norwegian Encore
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +5 more
15 nights · 2 departures
Balanced · 9 ports
CaribbeanExplora Journeys
A Journey through Enchanting Nature & the Marvels of the Panama Canal
Aboard EXPLORA III
Miami, Florida → At Sea → Ocho Rios → Willemstad +5 more
10 nights · 1 departure
Port-rich · 9 ports
AmericasRegent Seven Seas Cruises
Crescent Beaches & Colorful Towns
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Puerto Limón → Cruising the Caribbean Sea +8 more
11 nights · 1 departure
Port-rich · 12 ports
AmericasRegent Seven Seas Cruises
Carnival Of Caribbean Colors
Aboard Seven Seas Grandeur
Panama City → Panama Canal Transit → Cartagena → Santa Marta +11 more
14 nights · 1 departure
Port-rich · 15 ports
AmericasRegent Seven Seas Cruises
Tropical Treasures
Aboard Seven Seas Splendor
Miami, Florida → Cruising the Caribbean Sea → Cozumel → Costa Maya +8 more
14 nights · 1 departure
Port-rich · 12 ports
AmericasSilversea
Cartagena to Valparaiso
Aboard Silver Shadow
Cartagena → At Sea → Panama Canal Transit → Panama City +3 more
14 nights · 1 departure
Sea-paced · 7 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Jamaica
Aboard Norwegian Bliss
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +6 more
16 nights · 1 departure
Balanced · 10 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico, Costa Rica & Colombia
Aboard Norwegian Joy
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +6 more
16 nights · 1 departure
Balanced · 10 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Colombia
Aboard Norwegian Star
San Diego, California → Cabo San Lucas → Acapulco → Puerto Quetzal +6 more
16 nights · 1 departure
Balanced · 10 ports
AmericasRegent Seven Seas Cruises
Machu Picchu & Mayan Ruins
Aboard Seven Seas Mariner
Callao → Salaverry → Cruising the Pacific Ocean → Guayaquil +11 more
16 nights · 1 departure
Port-rich · 15 ports
AmericasVirgin Voyages
Panama Canal: LA to Miami Halloween
Aboard Brilliant Lady
Los Angeles, California → At Sea → Cabo San Lucas → Puerto Quetzal +5 more
17 nights · 1 departure
Balanced · 9 ports
AmericasSilversea
Valparaiso to Miami
Aboard Silver Nova
Valparaiso → At Sea → Arica → Callao +5 more
18 nights · 1 departure
Sea-paced · 9 ports
World CruiseExplora Journeys
Endless Worlds, our 108-day Inaugural World Journey 2029
Aboard EXPLORA I
Dubai → Khasab → At Sea → Mumbai (ex Bombay) +53 more
108 nights · 1 departure
Balanced · 57 ports
AmericasEmerald Cruises
Coastal Adventures: Costa Rica & Panama
Aboard Emerald Azzurra
Puerto Caldera → Curú Wildlife Refuge → Quepos (Puerto Quepos) → Golfito +5 more
7 nights · 2 departures
Port-rich · 9 ports
AmericasOceania Cruises
Panama Potpourri
Aboard Oceania Marina
Miami, Florida → At Sea → Cozumel → Costa Maya +6 more
10 nights · 2 departures
Port-rich · 10 ports
AmericasExplora Journeys
A Journey of Mayan Discovery & Mexican Exploration
Aboard EXPLORA III
Panama City → At Sea → Acajutla → Puerto Quetzal +4 more
11 nights · 1 departure
Balanced · 8 ports
AmericasRegent Seven Seas Cruises
Bon Bini Aruba
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Cartagena → Cruising the Caribbean Sea +8 more
12 nights · 1 departure
Port-rich · 12 ports
AmericasRegent Seven Seas Cruises
Exotic Coasts & Casco Viejo
Aboard Seven Seas Grandeur
Miami, Florida → Cruising the Florida Straits → Costa Maya → Harvest Caye +9 more
14 nights · 1 departure
Port-rich · 13 ports
PacificRegent Seven Seas Cruises
Canal To Coral Reefs
Aboard Seven Seas Splendor
Panama City → Cruising the Pacific Ocean → Puntarenas → Acajutla +10 more
28 nights · 1 departure
Balanced · 14 ports
World CruiseSilversea
World Cruise 2028
Aboard Silver Shadow
Miami, Florida → At Sea → Great Harbour, Jost Van Dyke → Gustavia +55 more
132 nights · 1 departure
Sea-paced · 59 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Bahamas
Aboard Norwegian Bliss
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +7 more
17 nights · 1 departure
Balanced · 11 ports
AmericasNorwegian Cruise Line
Panama Canal: Mexico & Jamaica
Aboard Norwegian Joy
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +7 more
17 nights · 1 departure
Balanced · 11 ports
World CruiseExplora Journeys
Endless Worlds, our 112-day Inaugural World Journey 2029
Aboard EXPLORA I
Dubai → Khasab → At Sea → Mumbai (ex Bombay) +55 more
112 nights · 1 departure
Balanced · 59 ports
AmericasEmerald Cruises
Coastal Adventures: Panama & Costa Rica
Aboard Emerald Azzurra
Panama City → Pearl Islands → Playa Muerto, Darién National Park → Darién National Park +5 more
7 nights · 2 departures
Port-rich · 9 ports
AmericasOceania Cruises
Spanish Lullaby
Aboard Oceania Marina
Panama City → Panama Canal Transit → At Sea → Puerto Limón +5 more
10 nights · 1 departure
Port-rich · 9 ports
CaribbeanExplora Journeys
A Grand Journey through Balmy Shores & Enchanting Nature to Panama’s Wonders
Aboard EXPLORA III
San Juan (Puerto Rico) → Gustavia → Little Bay → Basseterre, Saint Kitts +10 more
17 nights · 1 departure
Port-rich · 14 ports
CaribbeanRegent Seven Seas Cruises
Sapphire Sojourn
Aboard Seven Seas Prestige
Los Angeles, California → Cruising the Pacific Ocean → Cabo San Lucas → Mazatlán +4 more
12 nights · 1 departure
Balanced · 8 ports
AmericasRegent Seven Seas Cruises
Journey To The Amazon
Aboard Seven Seas Grandeur
Panama City → Panama Canal Transit → Cruising the Caribbean Sea → Oranjestad +8 more
22 nights · 1 departure
Balanced · 12 ports
PacificRegent Seven Seas Cruises
Tides To Tahiti
Aboard Seven Seas Splendor
Miami, Florida → Cruising the Caribbean Sea → Cozumel → Costa Maya +21 more
42 nights · 1 departure
Balanced · 25 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Jamaica
Aboard Norwegian Bliss
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +7 more
19 nights · 1 departure
Balanced · 11 ports
World CruiseExplora Journeys
Endless Worlds, our 128-day Inaugural World Journey 2029
Aboard EXPLORA I
Dubai → Khasab → At Sea → Mumbai (ex Bombay) +61 more
128 nights · 1 departure
Balanced · 65 ports
AmericasEmerald Cruises
Grenadines, Colombia & Panama Canal transit
Aboard Emerald Azzurra
Bridgetown → Port Elizabeth, Bequia → Mayreau Island → Kralendijk +7 more
11 nights · 2 departures
Port-rich · 11 ports
AmericasOceania Cruises
Panama To Caribbean Joy
Aboard Oceania Marina
Panama City → Panama Canal Transit → Cartagena → Santa Marta +6 more
10 nights · 1 departure
Port-rich · 10 ports
PacificExplora Journeys
An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders
Aboard EXPLORA III
Panama City → At Sea → Acajutla → Puerto Quetzal +8 more
18 nights · 1 departure
Balanced · 12 ports
AmericasRegent Seven Seas Cruises
Flavors Of Cartagena
Aboard Seven Seas Prestige
Miami, Florida → Key West, Florida → Cruising the Florida Straits → Georgetown, Grand Cayman +7 more
12 nights · 1 departure
Port-rich · 11 ports
World CruiseRegent Seven Seas Cruises
Navigate The World
Aboard Seven Seas Splendor
Miami, Florida → Cruising the Caribbean Sea → Cozumel → Costa Maya +80 more
127 nights · 1 departure
Balanced · 84 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Bahamas
Aboard Norwegian Bliss
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +8 more
20 nights · 1 departure
Balanced · 12 ports
AmericasEmerald Cruises
Panama Canal transit, Colombia & the Grenadines
Aboard Emerald Azzurra
Panama City → Panama Canal Transit → San Blas Islands → Cartagena +7 more
11 nights · 2 departures
Port-rich · 11 ports
AmericasOceania Cruises
Central American Seas
Aboard Oceania Marina
Miami, Florida → At Sea → Cozumel → Costa Maya +6 more
10 nights · 1 departure
Port-rich · 10 ports
CaribbeanExplora Journeys
An Extended Journey from Majestic Horizons to Mayan Gems
Aboard EXPLORA III
Miami, Florida → At Sea → Ocho Rios → Willemstad +11 more
21 nights · 1 departure
Balanced · 15 ports
AmericasRegent Seven Seas Cruises
Azure To Iberia
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Cartagena → Cruising the Caribbean Sea +13 more
26 nights · 1 departure
Balanced · 17 ports
World CruiseRegent Seven Seas Cruises
World Of Splendor
Aboard Seven Seas Splendor
Miami, Florida → Cruising the Caribbean Sea → Cozumel → Costa Maya +87 more
141 nights · 1 departure
Balanced · 91 ports
AmericasEmerald Cruises
Costa Rica, Panama from the Atlantic to the Pacific via the Panama Canal
Aboard Emerald Azzurra
Puerto Caldera → Curú Wildlife Refuge → Quepos (Puerto Quepos) → Golfito +9 more
12 nights · 2 departures
Port-rich · 13 ports
AmericasOceania Cruises
Treasures Of The Tropics
Aboard Oceania Marina
Miami, Florida → At Sea → Georgetown, Grand Cayman → Montego Bay +10 more
20 nights · 1 departure
Balanced · 14 ports
Frequently asked
- How many cruises to Panama City does NestCruise have?
- 51 live sailings, 10 to 108 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines visit Panama City?
- Regent Seven Seas Cruises, Emerald Cruises, Explora Journeys and Norwegian Cruise Line, among others.
- How long are cruises to Panama City?
- Most run 10 to 108 nights.
- How much do cruises to Panama City cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.