How many cruises to Panama City does NestCruise have?

50 live sailings, 10 to 28 nights. A NestCruise advisor narrows them to the one that fits.

Which cruise lines visit Panama City?

Regent Seven Seas Cruises, Emerald Cruises, Oceania Cruises and Norwegian Cruise Line, among others.

How much do cruises to Panama City cost?

NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.

(877) 837-3843

Cruises to Panama City

50 live cruises call at Panama City — 10 to 28 nights, departing 15 ports, across 8 lines. A NestCruise advisor narrows them to the one that fits.

50 sailings

Get my shortlist for these filtersFree · a real advisor replies within 24h

Discover the Secrets of Panama and Costa Rica

Caribbean

Emerald Cruises

18 nights in the Caribbean

Aboard Emerald Azzurra

Bridgetown → Puerto Caldera

Rare itinerary

from$17,540pp · cruise fare≈ $974/night pp

Fares checked nightly

Jan 2028 – Jan 2029Next 13 Jan 2028 · 2 more

Americas

Oceania Cruises

10 nights in South America

Aboard Oceania Marina

Panama City → Miami

Rare itinerary

Jan 2028 – Mar 2028Next 16 Jan 2028 · 1 more

Panama Canal

Norwegian Cruise Line

15 nights: Cabo San Lucas, the Panama Canal

Aboard Norwegian Encore

Los Angeles → Miami

↓ $1,149 this monthRisk-free Cancellation

from$1,769pp · cruise fare≈ $118/night pp

Fares checked nightly

Sails every two weeks, Jan 2028

Panama Canal

Virgin Voyages

17 nights: Cabo San Lucas, the Panama Canal

Aboard Brilliant Lady

Los Angeles → Miami

↓ $1,140 this monthRare itinerary

from$3,708pp · cruise fare≈ $218/night pp

Fares checked nightly

Oct 2026 – Nov 2027Next 29 Oct 2026 · 1 more

Caribbean & Central America

Explora Journeys

10 nights: Puerto Vallarta

Aboard EXPLORA III

Miami → Los Angeles

↓ $2,470 this monthVirtuoso

from$9,880pp · cruise fare≈ $988/night pp

Fares checked nightly

Apr 2027Next 12 Apr 2027

World Cruise

Silversea

10 nights: Buenos Aires & Rio de Janeiro

Aboard Silver Shadow

Miami → Nice

Overnight in Panama CityRare itinerary

from$6,000pp · cruise fare≈ $600/night pp

Fares checked nightly

Jan 2028Next 5 Jan 2028

Americas

Regent Seven Seas Cruises

11 nights: Cozumel, South America

Aboard Seven Seas Prestige

Panama City → Miami

Rare itinerary

Feb 2027Next 22 Feb 2027

Americas

Regent Seven Seas Cruises

14 nights in South America

Aboard Seven Seas Grandeur

Panama City → Miami

Overnight in Panama CityRare itinerary

Mar 2027Next 31 Mar 2027

Americas

Regent Seven Seas Cruises

14 nights: Cozumel, South America

Aboard Seven Seas Splendor

Miami → Panama City

Rare itinerary

Jan 2027Next 12 Jan 2027

Panama Canal

Norwegian Cruise Line

16 nights: Cabo San Lucas, the Panama Canal

Aboard Norwegian Bliss

Los Angeles → New York

↓ $1,179 this monthUnlimited Open Bar

from$1,829pp · cruise fare≈ $114/night pp

Fares checked nightly

Oct 2026Next 13 Oct 2026

Panama Canal

Norwegian Cruise Line

16 nights: Cabo San Lucas, the Panama Canal

Aboard Norwegian Joy

Los Angeles → Miami

↓ $799 this month50% Off All

from$1,489pp · cruise fare≈ $93/night pp

Fares checked nightly

Oct 2026Next 7 Oct 2026

Panama Canal

Norwegian Cruise Line

16 nights: Cabo San Lucas, the Panama Canal

Aboard Norwegian Star

San Diego → Miami

↓ $1,429 this monthRisk-free Cancellation

from$1,939pp · cruise fare≈ $121/night pp

Fares checked nightly

Feb 2027Next 13 Feb 2027

Americas

Regent Seven Seas Cruises

16 nights in South America

Aboard Seven Seas Mariner

Callao → Miami

Overnight in CallaoRare itinerary

Mar 2027Next 10 Mar 2027

South America

Holland America Line

17 nights: Grand Cayman, South America

Aboard Nieuw Amsterdam

San Antonio → Fort Lauderdale

Overnight in Panama CityRare itinerary

from$2,894pp · cruise fare≈ $170/night pp

Fares checked nightly

Mar 2028Next 21 Mar 2028

Americas

Silversea

18 nights: Cozumel, South America

Aboard Silver Nova

Valparaiso → Miami

↓ $1,250 this monthOvernight in Callao

from$12,300pp · cruise fare≈ $683/night pp

Fares checked nightly

Mar 2027Next 5 Mar 2027

World Journey

Explora Journeys

128 nights: Singapore & Barcelona

Aboard EXPLORA I

Dubai → Barcelona

↓ $4,875 this monthWinter 2028-2029

from$92,625pp · cruise fare≈ $724/night pp

Fares checked nightly

Jan 2029Next 6 Jan 2029

Americas

Emerald Cruises

Coastal Adventures: Costa Rica & Panama

Aboard Emerald Azzurra

Puerto Caldera → Panama City

↓ $597 this monthCaribbean Sale!

from$5,848pp · cruise fare≈ $835/night pp

Fares checked nightly

Feb 2028 – Feb 2029Next 22 Feb 2028 · 1 more

Americas

Oceania Cruises

10 nights: Cozumel, South America

Aboard Oceania Marina

Miami → Panama City

Rare itinerary

Jan 2027 – Mar 2027Next 5 Jan 2027 · 1 more

Central & North America Pacific Coast

Explora Journeys

11 nights: Puerto Vallarta & Vancouver

Aboard EXPLORA III

Panama City → Vancouver

↓ $3,025 this monthWinter 2026-2027

from$6,075pp · cruise fare≈ $552/night pp

Fares checked nightly

Apr 2027Next 22 Apr 2027

Americas

Silversea

14 nights in South America

Aboard Silver Shadow

Cartagena → Valparaiso

Overnight in ValparaisoRare itinerary

from$8,000pp · cruise fare≈ $571/night pp

Fares checked nightly

Jan 2028Next 15 Jan 2028

Americas

Regent Seven Seas Cruises

12 nights in South America

Aboard Seven Seas Prestige

Panama City → Miami

Rare itinerary

Mar 2028Next 14 Mar 2028

Americas

Regent Seven Seas Cruises

14 nights in South America

Aboard Seven Seas Grandeur

Miami → Panama City

↓ $16,599 this monthBonus Savings of

from$10,399pp · cruise fare≈ $743/night pp

Fares checked nightly

Feb 2027Next 23 Feb 2027

Pacific

Regent Seven Seas Cruises

28 nights: Cabo San Lucas & Honolulu

Aboard Seven Seas Splendor

Panama City → Papeete

Overnight in Los AngelesRare itinerary

Jan 2027Next 26 Jan 2027

Panama Canal

Norwegian Cruise Line

17 nights: Cabo San Lucas, the Panama Canal

Aboard Norwegian Bliss

Los Angeles → New York

↓ $1,699 this month50% Off All

from$2,359pp · cruise fare≈ $139/night pp

Fares checked nightly

Oct 2027Next 19 Oct 2027

17-Day Panama Canal from Los Angeles to Miami: Mexico & Jamaica

Caribbean

Norwegian Cruise Line

17 nights: Cabo San Lucas, the Caribbean

Aboard Norwegian Joy

Los Angeles → Miami

↓ $1,679 this monthRisk-free Cancellation

from$2,319pp · cruise fare≈ $136/night pp

Fares checked nightly

Sep 2027Next 30 Sep 2027

South America

Holland America Line

32 nights: Buenos Aires & Ushuaia, South America

Aboard Nieuw Amsterdam

Buenos Aires → Fort Lauderdale

Overnight in Buenos AiresRare itinerary

from$5,314pp · cruise fare≈ $166/night pp

Fares checked nightly

Mar 2028Next 6 Mar 2028

Americas

Emerald Cruises

7 nights in South America

Aboard Emerald Azzurra

Panama City → Puerto Caldera

↓ $597 this monthCaribbean Sale!

from$5,848pp · cruise fare≈ $835/night pp

Fares checked nightly

Jan 2028 – Jan 2029Next 24 Jan 2028 · 1 more

Americas

Oceania Cruises

10 nights: Cozumel, South America

Aboard Oceania Marina

Panama City → Miami

Rare itinerary

Mar 2028Next 15 Mar 2028

Caribbean & Central America

Explora Journeys

17 nights: San Juan

Aboard EXPLORA III

San Juan → Panama City

↓ $7,070 this monthWinter 2026-2027

from$13,930pp · cruise fare≈ $819/night pp

Fares checked nightly

Apr 2027Next 5 Apr 2027

Caribbean

Regent Seven Seas Cruises

12 nights: Cabo San Lucas, the Caribbean

Aboard Seven Seas Prestige

Los Angeles → Panama City

↓ $14,349 this monthBonus Savings of

from$8,349pp · cruise fare≈ $696/night pp

Fares checked nightly

Feb 2027Next 10 Feb 2027

Americas

Regent Seven Seas Cruises

The South America loop

Aboard Seven Seas Grandeur

Round-trip from Panama City

Overnight in Sailing the Atlantic OceanRare itinerary

Mar 2027Next 9 Mar 2027

Pacific

Regent Seven Seas Cruises

42 nights: Cozumel & Honolulu

Aboard Seven Seas Splendor

Miami → Papeete

Overnight in Los AngelesRare itinerary

Jan 2027Next 12 Jan 2027

Grenadines, Colombia & Panama Canal transit

Americas

Emerald Cruises

11 nights in South America

Aboard Emerald Azzurra

Bridgetown → Panama City

↓ $404 this monthIncludes Preferred Savings

from$8,841pp · cruise fare≈ $804/night pp

Fares checked nightly

Jan 2028 – Jan 2029Next 13 Jan 2028 · 1 more

Americas

Oceania Cruises

10 nights in South America

Aboard Oceania Marina

Panama City → Miami

Overnight in Panama CityRare itinerary

Jan 2027Next 15 Jan 2027

Americas

Regent Seven Seas Cruises

12 nights in South America

Aboard Seven Seas Prestige

Miami → Panama City

↓ $14,249 this monthBonus Savings of

from$8,249pp · cruise fare≈ $687/night pp

Fares checked nightly

Mar 2028Next 2 Mar 2028

World Cruise

Regent Seven Seas Cruises

127 nights: Honolulu & Singapore

Aboard Seven Seas Splendor

Miami → Civitavecchia

Overnight in MiamiRare itinerary

Jan 2027Next 11 Jan 2027

Panama Canal transit, Colombia & the Grenadines

Americas

Emerald Cruises

11 nights in South America

Aboard Emerald Azzurra

Panama City → Bridgetown

↓ $404 this monthIncludes Preferred Savings

from$8,841pp · cruise fare≈ $804/night pp

Fares checked nightly

Feb 2028 – Mar 2029Next 29 Feb 2028 · 1 more

Americas

Oceania Cruises

10 nights: Cozumel, South America

Aboard Oceania Marina

Miami → Panama City

Rare itinerary

Jan 2028Next 6 Jan 2028

Americas

Regent Seven Seas Cruises

26 nights in South America

Aboard Seven Seas Prestige

Panama City → Lisbon

Overnight in Sailing the Atlantic OceanRare itinerary

Mar 2028Next 14 Mar 2028

World Cruise

Regent Seven Seas Cruises

141 nights: Honolulu & Singapore

Aboard Seven Seas Splendor

Miami → New York

Overnight in MiamiRare itinerary

Jan 2027Next 11 Jan 2027

Costa Rica, Panama from the Atlantic to the Pacific via the Panama Canal

Americas

Emerald Cruises

12 nights in South America

Aboard Emerald Azzurra

Puerto Caldera → San José

↓ $502 this monthIncludes Preferred Savings

from$10,343pp · cruise fare≈ $862/night pp

Fares checked nightly

Jan 2028 – Jan 2029Next 31 Jan 2028 · 1 more

Americas

Oceania Cruises

20 nights: Cozumel

Aboard Oceania Marina

Round-trip from Miami

Rare itinerary

Mar 2028Next 5 Mar 2028

Costa Rica, Panama from the Pacific to the Atlantic via the Panama Canal

Americas

Emerald Cruises

12 nights in South America

Aboard Emerald Azzurra

San José → Puerto Caldera

↓ $502 this monthIncludes Preferred Savings

from$10,343pp · cruise fare≈ $862/night pp

Fares checked nightly

Feb 2028 – Feb 2029Next 10 Feb 2028 · 1 more

Americas

Oceania Cruises

20 nights: Cozumel

Aboard Oceania Marina

Round-trip from Miami

Rare itinerary

Jan 2028Next 6 Jan 2028

Caribbean

Emerald Cruises

18 nights in the Caribbean

Aboard Emerald Azzurra

Bridgetown → Panama City

Overnight in BridgetownRare itinerary

from$17,540pp · cruise fare≈ $974/night pp

Fares checked nightly

Jan 2028 – Jan 2029Next 6 Jan 2028 · 1 more

Caribbean

Oceania Cruises

20 nights: Cozumel, the Caribbean

Aboard Oceania Marina

Round-trip from Miami

Overnight in Panama CityRare itinerary

Jan 2027Next 5 Jan 2027

Panama Canal

Emerald Cruises

11 nights in the Panama Canal

Aboard Emerald Azzurra

Puerto Limón → Puntarenas

Rare itinerary

Feb 2028Next 11 Feb 2028

Panama Canal

Emerald Cruises

17 nights in the Panama Canal

Aboard Emerald Azzurra

Bridgetown → Panama City

Rare itinerary

Jan 2028Next 7 Jan 2028

Frequently asked

How many cruises to Panama City does NestCruise have?: 50 live sailings, 10 to 28 nights. A NestCruise advisor narrows them to the one that fits.
Which cruise lines visit Panama City?: Regent Seven Seas Cruises, Emerald Cruises, Oceania Cruises and Norwegian Cruise Line, among others.
How long are cruises to Panama City?: Most run 10 to 28 nights.
How much do cruises to Panama City cost?: NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.