Cruise itinerary
14-Night Americas Cruise from Miami, Florida
14 nights · Americas · 13 ports of call
14-night Americas cruise aboard Seven Seas Grandeur, departing Miami, Florida and calling at Cruising the Florida Straits, Costa Maya, Harvest Caye, Roatán Island, Cruising the Caribbean Sea and Georgetown, Grand Cayman and 6 more.
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At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- Panama City
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Cruising the Florida Straits
- Day3
Costa Maya
Arrive 07:00 · Depart 17:00
A purpose-built cruise port on Mexico's Caribbean coast in Quintana Roo, on the southern Costa Maya. It serves as a gateway to Mayan ruins at Chacchoben and Kohunlich, plus nearby reef snorkelling and the laid-back fishing village of Mahahual.
- Chacchoben ruins
- Mahahual village
- Reef snorkelling
- Day4
Harvest Caye
Arrive 07:00 · Depart 17:00
- Day5
Roatán Island
Arrive 07:00 · Depart 17:00
An island off the northern coast of Honduras in the western Caribbean, part of the Bay Islands. Roatán is known for the Mesoamerican Barrier Reef just offshore, the dive sites and beaches around West End and West Bay, and forested inland hills.
- West Bay Beach
- Barrier reef diving
- West End
- Day6
Cruising the Caribbean Sea
- Day7
Georgetown, Grand Cayman
Arrive 07:00 · Depart 16:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day8
Ocho Rios
Arrive 09:00 · Depart 17:00
A resort town on Jamaica's north coast, set among green hills and a string of beaches. The terraced cascades of Dunn's River Falls are the headline attraction, with botanical gardens, river tubing and reggae-filled markets close to the cruise pier.
- Dunn's River Falls
- Resort beaches
- Botanical gardens
- Day9
Cruising the Caribbean Sea
- Day10
Puerto Limón
Arrive 10:30 · Depart 19:30
A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
- Tortuguero canals
- Rainforest wildlife
- Banana country
- Day11
Cruising the Caribbean Sea
- Day12
Cartagena
Arrive 07:00 · Depart 14:30
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day13
Colón
Arrive 08:00 · Depart 18:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day14
Panama Canal Transit
Arrive 07:00 · Depart 19:00
Panama City
Arrive 20:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day15
Panama City
Depart 17:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Upcoming departures
- 23 Feb 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 14-night Americas cruise calls at Miami, Florida, Cruising the Florida Straits, Costa Maya, Harvest Caye, Roatán Island, Cruising the Caribbean Sea, Georgetown, Grand Cayman, Ocho Rios, Puerto Limón, Cartagena, Colón, Panama Canal Transit and Panama City.
How many days are spent at sea?
4 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in Panama City.
How long is this cruise?
14 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 23 Feb 2027. A NestCruise advisor can confirm current availability.