Cruise itinerary
22-Night Americas Cruise from Panama City
22 nights · Americas · 12 ports of call
22-night Americas cruise aboard Seven Seas Grandeur, departing Panama City and calling at Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Port-of-Spain, Sailing the Atlantic Ocean and Cruising Amazon River and 5 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 22 nights
- Region
- Americas · South America
- Departs
- Panama City
- Returns
- Panama City
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Depart 17:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day3
Cruising the Caribbean Sea
- Day4
Oranjestad
Arrive 10:00 · Depart 19:00
The capital of Aruba, set on the island's leeward south coast in the southern Caribbean. Oranjestad is known for its Dutch colonial façades along Wilhelminastraat, a free streetcar through downtown, and white-sand beaches like Eagle and Palm just north.
- Eagle Beach
- Palm Beach
- Dutch colonial centre
- Day5
Cruising the Caribbean Sea
- Day6
Port-of-Spain
Arrive 07:00 · Depart 13:00
- Day7
Sailing the Atlantic Ocean
- Day8
Sailing the Atlantic Ocean
- Day9
Cruising Amazon River
- Day10
Cruising Amazon River
- Day11
Manaus
Arrive 07:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day12
Manaus
Depart 16:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day13
Boca de Valeria
Arrive 10:00 · Depart 17:00
- Day14
Alter do Chão
Arrive 07:30 · Depart 15:00
- Day15
Cruising Amazon River
- Day16
Sailing the Atlantic Ocean
- Day17
Sailing the Atlantic Ocean
- Day18
Saint George's
Arrive 11:00 · Depart 18:00
The capital of Grenada in the eastern Caribbean, set around a horseshoe harbour ringed by red-roofed houses. Known as the Spice Isle for its nutmeg, the island offers Grand Anse beach, hillside Fort George and rainforest waterfalls inland.
- Grand Anse Beach
- Fort George
- Nutmeg plantations
- Day19
Cruising the Caribbean Sea
- Day20
Willemstad
Arrive 07:00 · Depart 14:00
The capital of Curaçao in the southern Caribbean, with a UNESCO-listed centre of Dutch colonial architecture. Willemstad is known for the candy-coloured waterfront of Handelskade, the swinging Queen Emma pontoon bridge, and its floating market.
- Handelskade façades
- Queen Emma Bridge
- Floating Market
- Day21
Cruising the Caribbean Sea
- Day22
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day23
Panama City
Arrive 07:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Upcoming departures
- 9 Mar 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 22-night Americas cruise calls at Panama City, Panama Canal Transit, Cruising the Caribbean Sea, Oranjestad, Port-of-Spain, Sailing the Atlantic Ocean, Cruising Amazon River, Manaus, Boca de Valeria, Alter do Chão, Saint George's and Willemstad.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Panama City.
How long is this cruise?
22 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 9 Mar 2027. A NestCruise advisor can confirm current availability.