Cruise itinerary
12-Night Americas Cruise from Panama City
12 nights · Americas · 12 ports of call
12-night Americas cruise aboard Seven Seas Prestige, departing Panama City and calling at Panama Canal Transit, Cartagena, Cruising the Caribbean Sea, Oranjestad, Willemstad and Saint George's and 5 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 12 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Panama City
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Prestige sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Arrive 07:00 · Depart 16:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
Panama Canal Transit
- Day3
Cartagena
Arrive 12:00 · Depart 20:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day4
Cruising the Caribbean Sea
- Day5
Oranjestad
Arrive 07:00 · Depart 17:00
The capital of Aruba, set on the island's leeward south coast in the southern Caribbean. Oranjestad is known for its Dutch colonial façades along Wilhelminastraat, a free streetcar through downtown, and white-sand beaches like Eagle and Palm just north.
- Eagle Beach
- Palm Beach
- Dutch colonial centre
- Day6
Willemstad
Arrive 07:00 · Depart 17:00
The capital of Curaçao in the southern Caribbean, with a UNESCO-listed centre of Dutch colonial architecture. Willemstad is known for the candy-coloured waterfront of Handelskade, the swinging Queen Emma pontoon bridge, and its floating market.
- Handelskade façades
- Queen Emma Bridge
- Floating Market
- Day7
Cruising the Caribbean Sea
- Day8
Saint George's
Arrive 07:00 · Depart 17:00
The capital of Grenada in the eastern Caribbean, set around a horseshoe harbour ringed by red-roofed houses. Known as the Spice Isle for its nutmeg, the island offers Grand Anse beach, hillside Fort George and rainforest waterfalls inland.
- Grand Anse Beach
- Fort George
- Nutmeg plantations
- Day9
Roseau
Arrive 07:00 · Depart 16:00
The capital of Dominica, a green volcanic island in the eastern Caribbean known as the Nature Isle. The town sits below forested peaks, with the botanic gardens, sulphur springs and the trail to Trafalgar Falls a short drive inland.
- Trafalgar Falls
- Botanic Gardens
- Boiling Lake
- Day10
Charlotte Amalie
Arrive 09:00 · Depart 17:00
St. Thomas's harbour town in the U.S. Virgin Islands — a deep, sheltered bay ringed by red-roofed hills. Known for duty-free shopping along Main Street and the easy hop to Magens Bay or a ferry across to quieter St. John.
- Magens Bay
- Main Street shopping
- ferry to St. John
- Day11
Sailing the Atlantic Ocean
- Day12
Cruising the Bahamian Waters
- Day13
Miami, Florida
Arrive 07:00 · Depart 16:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 14 Mar 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 12-night Americas cruise calls at Panama City, Panama Canal Transit, Cartagena, Cruising the Caribbean Sea, Oranjestad, Willemstad, Saint George's, Roseau, Charlotte Amalie, Sailing the Atlantic Ocean, Cruising the Bahamian Waters and Miami, Florida.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Miami, Florida.
How long is this cruise?
12 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 14 Mar 2028. A NestCruise advisor can confirm current availability.