Cruise itinerary
14-Night Americas Cruise from Panama City
14 nights · Americas · 15 ports of call
14-night Americas cruise aboard Seven Seas Grandeur, departing Panama City and calling at Panama Canal Transit, Cartagena, Santa Marta, Oranjestad, Willemstad and Kralendijk and 8 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Panama City
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Arrive 07:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
Panama City
Depart 04:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day3
Cartagena
Arrive 11:00 · Depart 20:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day4
Santa Marta
Arrive 07:00 · Depart 16:00
- Day5
Oranjestad
Arrive 11:00 · Depart 21:00
The capital of Aruba, set on the island's leeward south coast in the southern Caribbean. Oranjestad is known for its Dutch colonial façades along Wilhelminastraat, a free streetcar through downtown, and white-sand beaches like Eagle and Palm just north.
- Eagle Beach
- Palm Beach
- Dutch colonial centre
- Day6
Willemstad
Arrive 07:00 · Depart 19:00
The capital of Curaçao in the southern Caribbean, with a UNESCO-listed centre of Dutch colonial architecture. Willemstad is known for the candy-coloured waterfront of Handelskade, the swinging Queen Emma pontoon bridge, and its floating market.
- Handelskade façades
- Queen Emma Bridge
- Floating Market
- Day7
Kralendijk
Arrive 07:00 · Depart 17:00
The capital of Bonaire, a Dutch-Caribbean island known above all for diving and snorkelling along its protected fringing reef. The small waterfront town keeps pastel Dutch-colonial facades, with salt pans and flamingo flats lying to the south.
- Bonaire reef diving
- Salt pans
- Flamingo flats
- Day8
Cruising the Caribbean Sea
- Day9
Saint George's
Arrive 08:00 · Depart 18:00
The capital of Grenada in the eastern Caribbean, set around a horseshoe harbour ringed by red-roofed houses. Known as the Spice Isle for its nutmeg, the island offers Grand Anse beach, hillside Fort George and rainforest waterfalls inland.
- Grand Anse Beach
- Fort George
- Nutmeg plantations
- Day10
Castries
Arrive 07:00 · Depart 16:00
The capital of St. Lucia, tucked into a sheltered harbour on the island's northwest coast. Beyond the market town rise the rainforested interior and the iconic twin Piton peaks further south along the volcanic coastline.
- The Pitons
- Central market
- Pigeon Island
- Day11
Gustavia
Arrive 09:00 · Depart 18:00
The harbour capital of St. Barthélemy, a chic French island in the Caribbean. Yachts crowd the small port below red-roofed hills, with designer boutiques along the quay and quiet coves and beaches scattered around the rugged coast.
- Shell Beach
- Designer boutiques
- Gustavia harbour
- Day12
Tortola
Arrive 08:00 · Depart 16:00
The main island of the British Virgin Islands, where steep green hills drop to a yacht-filled harbour at Road Town. It is a noted sailing base in the Caribbean, with quiet bays such as Cane Garden and ferries out to neighbouring Virgin Gorda.
- Road Town
- Cane Garden Bay
- Sailing charters
- Day13
Sailing the Atlantic Ocean
- Day14
Cruising the Bahamian Waters
- Day15
Miami, Florida
Arrive 07:00 · Depart 21:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 31 Mar 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 14-night Americas cruise calls at Panama City, Panama Canal Transit, Cartagena, Santa Marta, Oranjestad, Willemstad, Kralendijk, Cruising the Caribbean Sea, Saint George's, Castries, Gustavia, Tortola, Sailing the Atlantic Ocean, Cruising the Bahamian Waters and Miami, Florida.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Miami, Florida.
How long is this cruise?
14 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 31 Mar 2027. A NestCruise advisor can confirm current availability.