Cruise itinerary
10-Night Americas Cruise from Panama City
10 nights · Americas · 10 ports of call
10-night Americas cruise aboard Oceania Marina, departing Panama City and calling at Panama Canal Transit, Cartagena, Santa Marta, Oranjestad, Willemstad and At Sea and 3 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Marina
- Cruise line
- Oceania Cruises
- Duration
- 10 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Panama City
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Marina sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
Panama City
Depart 04:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Panama Canal Transit
- Day3
Cartagena
Arrive 11:00 · Depart 20:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day4
Santa Marta
Arrive 07:00 · Depart 16:00
- Day5
Oranjestad
Arrive 11:00 · Depart 20:00
The capital of Aruba, set on the island's leeward south coast in the southern Caribbean. Oranjestad is known for its Dutch colonial façades along Wilhelminastraat, a free streetcar through downtown, and white-sand beaches like Eagle and Palm just north.
- Eagle Beach
- Palm Beach
- Dutch colonial centre
- Day6
Willemstad
Arrive 07:00 · Depart 19:00
The capital of Curaçao in the southern Caribbean, with a UNESCO-listed centre of Dutch colonial architecture. Willemstad is known for the candy-coloured waterfront of Handelskade, the swinging Queen Emma pontoon bridge, and its floating market.
- Handelskade façades
- Queen Emma Bridge
- Floating Market
- Day7
At Sea
- Day8
Falmouth
Arrive 07:00 · Depart 17:00
- Day9
Georgetown, Grand Cayman
Arrive 09:00 · Depart 17:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day10
At Sea
- Day11
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 15 Jan 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
10-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 10-night Americas cruise calls at Panama City, Panama Canal Transit, Cartagena, Santa Marta, Oranjestad, Willemstad, At Sea, Falmouth, Georgetown, Grand Cayman and Miami, Florida.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Miami, Florida.
How long is this cruise?
10 nights aboard Oceania Marina.
When does this itinerary sail?
Upcoming departures include 15 Jan 2027. A NestCruise advisor can confirm current availability.