Cruise itinerary
11-Night Americas Cruise from Panama City
11 nights · Americas · 12 ports of call
11-night Americas cruise aboard Seven Seas Prestige, departing Panama City and calling at Panama Canal Transit, Puerto Limón, Cruising the Caribbean Sea, Roatán Island, Harvest Caye and Santo Tomás de Castilla and 5 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 11 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Panama City
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Prestige sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Arrive 07:00 · Depart 17:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day3
Puerto Limón
Arrive 08:00 · Depart 18:00
A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
- Tortuguero canals
- Rainforest wildlife
- Banana country
- Day4
Cruising the Caribbean Sea
- Day5
Roatán Island
Arrive 11:00 · Depart 18:00
An island off the northern coast of Honduras in the western Caribbean, part of the Bay Islands. Roatán is known for the Mesoamerican Barrier Reef just offshore, the dive sites and beaches around West End and West Bay, and forested inland hills.
- West Bay Beach
- Barrier reef diving
- West End
- Day6
Harvest Caye
Arrive 08:00 · Depart 17:00
- Day7
Santo Tomás de Castilla
Arrive 07:00 · Depart 13:00
- Day8
Cozumel
Arrive 08:00 · Depart 15:00
An island off Mexico's Yucatán coast in the Caribbean, a leading port for snorkelling and diving. Ships dock beside its reefs, part of the Mesoamerican system, with beach clubs, Mayan ruins and the resort strip of the Riviera Maya within reach.
- Coral reefs
- Mayan ruins
- Beach clubs
- Day9
Georgetown, Grand Cayman
Arrive 11:00 · Depart 16:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day10
Montego Bay
Arrive 07:00 · Depart 13:00
- Day11
Cruising the Florida Straits
- Day12
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 22 Feb 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
11-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 11-night Americas cruise calls at Panama City, Panama Canal Transit, Puerto Limón, Cruising the Caribbean Sea, Roatán Island, Harvest Caye, Santo Tomás de Castilla, Cozumel, Georgetown, Grand Cayman, Montego Bay, Cruising the Florida Straits and Miami, Florida.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Miami, Florida.
How long is this cruise?
11 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 22 Feb 2027. A NestCruise advisor can confirm current availability.