Cruise itinerary
12-Night Caribbean Cruise from Los Angeles, California
12 nights · Caribbean · 8 ports of call
12-night Caribbean cruise aboard Seven Seas Prestige, departing Los Angeles, California and calling at Cruising the Pacific Ocean, Cabo San Lucas, Mazatlán, Acapulco, Puerto Quetzal and Puntarenas and 1 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 12 nights
- Region
- Caribbean · Americas · South America · Panama Canal
- Departs
- Los Angeles, California
- Returns
- Panama City
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Prestige sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Los Angeles, California
Arrive 07:00 · Depart 17:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
- Day2
Cruising the Pacific Ocean
- Day3
Cruising the Pacific Ocean
- Day4
Cabo San Lucas
Arrive 08:00 · Depart 18:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day5
Mazatlán
Arrive 07:00 · Depart 18:00
A Pacific-coast resort city in Sinaloa, Mexico, strung along one of the longest seafront promenades in the country. The old town centres on the cathedral and Plaza Machado, while the Golden Zone draws beachgoers and the working harbour still lands shrimp.
- El Malecón
- Old Mazatlán
- Stone Island
- Day6
Cruising the Pacific Ocean
- Day7
Acapulco
Arrive 07:00 · Depart 18:00
- Day8
Cruising the Pacific Ocean
- Day9
Puerto Quetzal
Arrive 08:00 · Depart 18:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day10
Cruising the Pacific Ocean
- Day11
Puntarenas
Arrive 08:00 · Depart 18:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day12
Cruising the Pacific Ocean
- Day13
Panama City
Arrive 07:00 · Depart 17:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Upcoming departures
- 10 Feb 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Caribbean Cruise from Los Angeles, California FAQ
Which ports does this cruise visit?
This 12-night Caribbean cruise calls at Los Angeles, California, Cruising the Pacific Ocean, Cabo San Lucas, Mazatlán, Acapulco, Puerto Quetzal, Puntarenas and Panama City.
How many days are spent at sea?
6 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Los Angeles, California and ends in Panama City.
How long is this cruise?
12 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 10 Feb 2027. A NestCruise advisor can confirm current availability.