Cruise itinerary
17-Night Panama Canal Cruise from Los Angeles, California
17 nights · Panama Canal · 8 ports of call
17-night Panama Canal cruise aboard Brilliant Lady, departing Los Angeles, California and calling at Cabo San Lucas, Puerto Quetzal, Puntarenas, Panama City, Panama Canal Transit and Cartagena and 1 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Brilliant Lady
- Cruise line
- Virgin Voyages
- Duration
- 17 nights
- Region
- Panama Canal
- Departs
- Los Angeles, California
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Brilliant Lady sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Los Angeles, California
Depart 17:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
- Day2At sea
- Day3At sea
- Day4
Cabo San Lucas
Arrive 08:00 · Depart 17:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day5At sea
- Day6At sea
- Day7At sea
- Day8
Puerto Quetzal
Arrive 08:00 · Depart 20:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day9At sea
- Day10
Puntarenas
Arrive 08:00 · Depart 18:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day11At sea
- Day12
Panama City
Arrive 09:00 · Depart 19:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day13
Panama Canal Transit
- Day14
Cartagena
Arrive 13:00 · Depart 17:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day15At sea
- Day16At sea
- Day17At sea
- Day18
Miami, Florida
Arrive 06:30
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 29 Oct 2026
- 27 Nov 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
17-Night Panama Canal Cruise from Los Angeles, California FAQ
Which ports does this cruise visit?
This 17-night Panama Canal cruise calls at Los Angeles, California, Cabo San Lucas, Puerto Quetzal, Puntarenas, Panama City, Panama Canal Transit, Cartagena and Miami, Florida.
How many days are spent at sea?
10 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Los Angeles, California and ends in Miami, Florida.
How long is this cruise?
17 nights aboard Brilliant Lady.
When does this itinerary sail?
Upcoming departures include 29 Oct 2026 and 27 Nov 2027. A NestCruise advisor can confirm current availability.