Cruise itinerary
12-Night Americas Cruise from Miami, Florida
12 nights · Americas · 11 ports of call
12-night Americas cruise aboard Seven Seas Prestige, departing Miami, Florida and calling at Key West, Florida, Cruising the Florida Straits, Georgetown, Grand Cayman, Falmouth, Cruising the Caribbean Sea and Cabo Rojo and 4 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 12 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- Panama City
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Prestige sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 16:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Key West, Florida
Arrive 08:00 · Depart 16:00
The southernmost city in the continental United States, an island town at the end of the Florida Keys. Pastel conch houses line Duval Street, Ernest Hemingway's home is a landmark, and crowds gather at Mallory Square for the nightly sunset.
- Duval Street
- Hemingway House
- Mallory Square sunset
- Day3
Cruising the Florida Straits
- Day4
Georgetown, Grand Cayman
Arrive 08:00 · Depart 17:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day5
Falmouth
Arrive 08:00 · Depart 17:00
A restored Georgian port town on Jamaica's north coast, purpose-built for large cruise ships. Streets of 18th-century merchant houses sit just beyond the pier, with Montego Bay's beaches and the Martha Brae's bamboo-raft river a short drive west.
- Georgian streets
- Martha Brae rafting
- Montego Bay
- Day6
Cruising the Caribbean Sea
- Day7
Cabo Rojo
Arrive 08:00 · Depart 17:00
A remote stretch of the Dominican Republic's far southwest, near the Pedernales frontier with Haiti. The wider region is known for the turquoise water of Bahía de las Águilas and the arid Jaragua National Park.
- Bahía de las Águilas
- Jaragua park
- Caribbean coast
- Day8
Cruising the Caribbean Sea
- Day9
Cartagena
Arrive 08:00 · Depart 17:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day10
Cruising the Caribbean Sea
- Day11
Puerto Limón
Arrive 08:00 · Depart 17:00
A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
- Tortuguero canals
- Rainforest wildlife
- Banana country
- Day12
Panama Canal Transit
- Day13
Panama City
Arrive 07:00 · Depart 16:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
Upcoming departures
- 2 Mar 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 12-night Americas cruise calls at Miami, Florida, Key West, Florida, Cruising the Florida Straits, Georgetown, Grand Cayman, Falmouth, Cruising the Caribbean Sea, Cabo Rojo, Cartagena, Puerto Limón, Panama Canal Transit and Panama City.
How many days are spent at sea?
4 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in Panama City.
How long is this cruise?
12 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 2 Mar 2028. A NestCruise advisor can confirm current availability.