Cruises from Panama City
13 live cruises sail from Panama City — 10 to 26 nights, across 4 lines, through Americas. A NestCruise advisor narrows them to the one that fits.
AmericasEmerald Cruises
Coastal Adventures: Panama & Costa Rica
Aboard Emerald Azzurra
Panama City → Pearl Islands → Playa Muerto, Darién National Park → Darién National Park +5 more
7 nights · 2 departures
Port-rich · 9 ports
AmericasOceania Cruises
Classic Canal & Tropics
Aboard Oceania Marina
Panama City → Panama Canal Transit → Cartagena → At Sea +5 more
10 nights · 2 departures
Port-rich · 9 ports
AmericasExplora Journeys
A Journey of Mayan Discovery & Mexican Exploration
Aboard EXPLORA III
Panama City → At Sea → Acajutla → Puerto Quetzal +4 more
11 nights · 1 departure
Balanced · 8 ports
AmericasRegent Seven Seas Cruises
Crescent Beaches & Colorful Towns
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Puerto Limón → Cruising the Caribbean Sea +8 more
11 nights · 1 departure
Port-rich · 12 ports
AmericasRegent Seven Seas Cruises
Carnival Of Caribbean Colors
Aboard Seven Seas Grandeur
Panama City → Panama Canal Transit → Cartagena → Santa Marta +11 more
14 nights · 1 departure
Port-rich · 15 ports
PacificRegent Seven Seas Cruises
Canal To Coral Reefs
Aboard Seven Seas Splendor
Panama City → Cruising the Pacific Ocean → Puntarenas → Acajutla +10 more
28 nights · 1 departure
Balanced · 14 ports
AmericasEmerald Cruises
Panama Canal transit, Colombia & the Grenadines
Aboard Emerald Azzurra
Panama City → Panama Canal Transit → San Blas Islands → Cartagena +7 more
11 nights · 2 departures
Port-rich · 11 ports
AmericasOceania Cruises
Spanish Lullaby
Aboard Oceania Marina
Panama City → Panama Canal Transit → At Sea → Puerto Limón +5 more
10 nights · 1 departure
Port-rich · 9 ports
PacificExplora Journeys
An Extended Journey of Ancient Mysteries & Pacific Coastal Wonders
Aboard EXPLORA III
Panama City → At Sea → Acajutla → Puerto Quetzal +8 more
18 nights · 1 departure
Balanced · 12 ports
AmericasRegent Seven Seas Cruises
Bon Bini Aruba
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Cartagena → Cruising the Caribbean Sea +8 more
12 nights · 1 departure
Port-rich · 12 ports
AmericasRegent Seven Seas Cruises
Journey To The Amazon
Aboard Seven Seas Grandeur
Panama City → Panama Canal Transit → Cruising the Caribbean Sea → Oranjestad +8 more
22 nights · 1 departure
Balanced · 12 ports
Frequently asked
- How many cruises from Panama City does NestCruise have?
- 13 live sailings, 10 to 26 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines sail from Panama City?
- Regent Seven Seas Cruises, Oceania Cruises, Emerald Cruises and Explora Journeys, among others.
- How long are cruises from Panama City?
- Most run 10 to 26 nights.
- How much do cruises from Panama City cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.