Cruise itinerary
11-Night Americas Cruise from Panama City
11 nights · Americas · 8 ports of call
11-night Americas cruise aboard EXPLORA III, departing Panama City and calling at At Sea, Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa María Huatulco) and Puerto Vallarta and 1 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- EXPLORA III
- Cruise line
- Explora Journeys
- Duration
- 11 nights
- Region
- Americas · Central America
- Departs
- Panama City
- Returns
- Los Angeles, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact EXPLORA III sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Panama City
Depart 20:00
Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
- Panama Canal
- Casco Viejo
- Miraflores Locks
- Day2
At Sea
- Day3
At Sea
- Day4
Acajutla
Arrive 08:00 · Depart 18:00
- Day5
Puerto Quetzal
Arrive 08:00 · Depart 18:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day6
Puerto Madero
Arrive 08:00 · Depart 17:00
- Day7
Huatulco (Santa María Huatulco)
Arrive 08:00 · Depart 17:00
- Day8
At Sea
- Day9
Puerto Vallarta
Arrive 09:00 · Depart 17:00
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day10
At Sea
- Day11
At Sea
- Day12
Los Angeles, California
Arrive 08:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
Upcoming departures
- 22 Apr 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
11-Night Americas Cruise from Panama City FAQ
Which ports does this cruise visit?
This 11-night Americas cruise calls at Panama City, At Sea, Acajutla, Puerto Quetzal, Puerto Madero, Huatulco (Santa María Huatulco), Puerto Vallarta and Los Angeles, California.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Panama City and ends in Los Angeles, California.
How long is this cruise?
11 nights aboard EXPLORA III.
When does this itinerary sail?
Upcoming departures include 22 Apr 2027. A NestCruise advisor can confirm current availability.