Panama Canal cruises
96 live sailings explore Panama Canal — 11 to 22 nights, departing 17 ports, across 13 lines. A NestCruise advisor narrows them to the one that fits.
AmericasCelebrity Cruises
11 Nt Panama Canal & Southern Caribbean
Aboard Celebrity Ascent
Fort Lauderdale, Florida → Cartagena → Panama Canal Transit → Colón +3 more
11 nights · 6 departures
Balanced · 7 ports
AmericasHolland America Line
12-Day Panama Canal Discovery: Costa Rica & Greater Antilles
Aboard Nieuw Amsterdam
Fort Lauderdale, Florida → Half Moon Cay → Aruba → Cartagena +5 more
12 nights · 6 departures
Balanced · 9 ports
AmericasHolland America Line
12-Day Panama Canal Discovery: Costa Rica & Greater Antilles
Aboard Oosterdam
Fort Lauderdale, Florida → Half Moon Cay → Aruba → Cartagena +5 more
12 nights · 5 departures
Balanced · 9 ports
AmericasNorwegian Cruise Line
11-day Cruise on Norwegian Sun
Aboard Norwegian Sun
Miami, Florida → Falmouth → Cartagena → Colón +4 more
11 nights · 4 departures
Balanced · 8 ports
AmericasCarnival Cruise Line
Journeys - 16-Day Panama Canal
Aboard Carnival Spirit
Seattle, Washington → At Sea → Cabo San Lucas → Puntarenas +3 more
16 nights · 3 departures
Sea-paced · 7 ports
AmericasHolland America Line
16-Day Panama Canal
Aboard Eurodam
San Diego, California → Cabo San Lucas → Acapulco → Huatulco (Santa María Huatulco) +5 more
16 nights · 3 departures
Balanced · 9 ports
CaribbeanEmerald Cruises
Discover the Secrets of Panama and Costa Rica
Aboard Emerald Azzurra
Bridgetown → Port Elizabeth, Bequia → Mayreau Island → Kralendijk +15 more
18 nights · 3 departures
Port-rich · 19 ports
AmericasOceania Cruises
Classic Canal & Tropics
Aboard Oceania Marina
Panama City → Panama Canal Transit → Cartagena → At Sea +5 more
10 nights · 2 departures
Port-rich · 9 ports
AmericasNorwegian Cruise Line
Panama Canal: Bahamas, Jamaica & Costa Rica
Aboard Norwegian Gem
Miami, Florida → Great Stirrup Cay → Cartagena → Colón +3 more
10 nights · 2 departures
Balanced · 7 ports
AmericasHolland America Line
14-Day Panama Canal
Aboard Zaandam
Fort Lauderdale, Florida → Cartagena → Quepos (Puerto Quepos) → Puerto Quetzal +4 more
14 nights · 2 departures
Balanced · 8 ports
AmericasVirgin Voyages
Panama Canal: Miami to Los Angeles
Aboard Brilliant Lady
Miami, Florida → At Sea → Cartagena → Colón +5 more
16 nights · 2 departures
Balanced · 9 ports
AmericasAzamara
Belize, Costa Rica & Panama Cruise: Belize City, Puerto Limon & Panama City
Aboard Azamara Quest
Miami, Florida → Cozumel → Belize City → Roatán Island +4 more
9 nights · 1 departure
Port-rich · 8 ports
CaribbeanRegent Seven Seas Cruises
West Coast Retreat
Aboard Seven Seas Grandeur
Los Angeles, California → Cruising the Pacific Ocean → Cabo San Lucas → La Paz +3 more
10 nights · 1 departure
Balanced · 7 ports
CaribbeanRegent Seven Seas Cruises
Baja Breezes
Aboard Seven Seas Prestige
Los Angeles, California → Cruising the Pacific Ocean → Cabo San Lucas → La Paz +3 more
10 nights · 1 departure
Balanced · 7 ports
AmericasNorwegian Cruise Line
Panama Canal: Mexico, Costa Rica & Belize
Aboard Norwegian Jewel
Miami, Florida → Georgetown, Grand Cayman → Cartagena → Colón +4 more
11 nights · 1 departure
Balanced · 8 ports
AmericasCrystal
Fuerte Amador (Panama City) to New York
Aboard Crystal Serenity
Fuerte Amador → Panama Canal Transit → Cartagena → At Sea +7 more
14 nights · 1 departure
Port-rich · 11 ports
AmericasDisney Cruise Line
14-Night Westbound Panama Canal Cruise from Galveston ending in San Diego
Aboard Disney Magic
Galveston, Texas → At Sea → Cozumel → Cartagena +4 more
14 nights · 1 departure
Balanced · 8 ports
AmericasHolland America Line
14-Day Panama Canal
Aboard Zuiderdam
Miami, Florida → Cartagena → Puntarenas → Puerto Quetzal +4 more
14 nights · 1 departure
Balanced · 8 ports
AmericasAzamara
Aruba, Colombia & Panama Cruise: Oranjestad, Cartagena & Panama City
Aboard Azamara Onward
Miami, Florida → Oranjestad → Willemstad → Cartagena +4 more
14 nights · 1 departure
Balanced · 8 ports
AmericasRegent Seven Seas Cruises
Tropical Treasures
Aboard Seven Seas Splendor
Miami, Florida → Cruising the Caribbean Sea → Cozumel → Costa Maya +8 more
14 nights · 1 departure
Port-rich · 12 ports
AmericasRegent Seven Seas Cruises
Empires Of The Sun
Aboard Seven Seas Voyager
Miami, Florida → Cruising the Florida Straits → Georgetown, Grand Cayman → Falmouth +9 more
14 nights · 1 departure
Port-rich · 13 ports
AmericasCelebrity Cruises
15 Night Panama Canal Westward Cruise
Aboard Celebrity Summit
Tampa, Florida → Georgetown, Grand Cayman → Cartagena → Colón +4 more
15 nights · 1 departure
Balanced · 8 ports
AmericasCrystal
Fort Lauderdale to San Diego
Aboard Crystal Symphony
Fort Lauderdale, Florida → At Sea → Cartagena → Panama Canal Transit +5 more
15 nights · 1 departure
Balanced · 9 ports
AmericasRoyal Caribbean International
15 Night Panama Canal Eastward Cruise
Aboard Serenade of the Seas
San Diego, California → Puerto Vallarta → Puerto Quetzal → Puntarenas +4 more
15 nights · 1 departure
Balanced · 8 ports
AmericasOceania Cruises
Treasures Of Two Oceans
Aboard Oceania Vista
Miami, Florida → At Sea → Georgetown, Grand Cayman → Cartagena +6 more
15 nights · 1 departure
Balanced · 10 ports
AmericasCarnival Cruise Line
Journeys - 16-Day Panama Canal
Aboard Carnival Legend
Tampa, Florida → At Sea → Santa Marta → Cartagena +4 more
16 nights · 1 departure
Sea-paced · 8 ports
AmericasCarnival Cruise Line
Journeys - 16-Day Panama Canal
Aboard Carnival Miracle
Seattle, Washington → At Sea → Cabo San Lucas → Puntarenas +3 more
16 nights · 1 departure
Sea-paced · 7 ports
AmericasNorwegian Cruise Line
Panama Canal: Mexico & Costa Rica
Aboard Norwegian Star
Miami, Florida → Cartagena → Colón → Córdoba +6 more
16 nights · 1 departure
Balanced · 10 ports
AmericasOceania Cruises
Panama Canal Coastlines
Aboard Oceania Sonata
Los Angeles, California → Ensenada → At Sea → Cabo San Lucas +7 more
16 nights · 1 departure
Balanced · 11 ports
AmericasSeabourn
16-Day Panama Canal & Historic Coasts Of South America
Aboard Seabourn Pursuit
Aruba → Fuerte Amador → Guayaquil → Callao +2 more
16 nights · 1 departure
Sea-paced · 6 ports
AmericasNorwegian Cruise Line
Panama Canal: Mexico & Jamaica
Aboard Norwegian Joy
Los Angeles, California → Cabo San Lucas → Acapulco → Puerto Quetzal +7 more
17 nights · 1 departure
Balanced · 11 ports
AmericasSeabourn
19-Day World Cruise: Panama Canal Crossing
Aboard Seabourn Quest
Long Beach, California → Puerto Vallarta → Huatulco (Santa María Huatulco) → Puerto Chiapas +4 more
19 nights · 1 departure
Sea-paced · 8 ports
AmericasHolland America Line
21-Day Panama Canal
Aboard Nieuw Amsterdam
Vancouver, British Columbia → San Francisco, California → San Diego, California → Puerto Vallarta +7 more
21 nights · 2 departures
Balanced · 11 ports
AmericasHolland America Line
15-Day Panama Canal
Aboard Oosterdam
Fort Lauderdale, Florida → Aruba → Puntarenas → Puerto Quetzal +3 more
15 nights · 1 departure
Sea-paced · 7 ports
AmericasNorwegian Cruise Line
Panama Canal: Bahamas & Costa Rica
Aboard Norwegian Sun
Miami, Florida → Great Stirrup Cay → Cabo Rojo → Willemstad +5 more
12 nights · 4 departures
Balanced · 9 ports
AmericasHolland America Line
20-Day Panama Canal
Aboard Eurodam
Vancouver, British Columbia → Santa Barbara, California → San Diego, California → Cabo San Lucas +7 more
20 nights · 3 departures
Balanced · 11 ports
AmericasEmerald Cruises
Grenadines, Colombia & Panama Canal transit
Aboard Emerald Azzurra
Bridgetown → Port Elizabeth, Bequia → Mayreau Island → Kralendijk +7 more
11 nights · 2 departures
Port-rich · 11 ports
AmericasOceania Cruises
Panama Potpourri
Aboard Oceania Marina
Miami, Florida → At Sea → Cozumel → Costa Maya +6 more
10 nights · 2 departures
Port-rich · 10 ports
AmericasNorwegian Cruise Line
Panama Canal: Bahamas, Jamaica & Costa Rica
Aboard Norwegian Gem
Miami, Florida → Great Stirrup Cay → Cartagena → Colón +4 more
11 nights · 2 departures
Balanced · 8 ports
AmericasHolland America Line
15-Day Panama Canal Holiday
Aboard Zaandam
San Diego, California → Cabo San Lucas → Puerto Vallarta → Huatulco (Santa María Huatulco) +4 more
15 nights · 2 departures
Balanced · 8 ports
AmericasVirgin Voyages
Panama Canal: LA to Miami Halloween
Aboard Brilliant Lady
Los Angeles, California → At Sea → Cabo San Lucas → Puerto Quetzal +5 more
17 nights · 1 departure
Balanced · 9 ports
AmericasAzamara
Panama, Ecuadaor & Peru Cruise: Panama City, Manta & Lima (Callao)
Aboard Azamara Quest
Fuerte Amador → Manta → Lima → Pisco +2 more
10 nights · 1 departure
Balanced · 6 ports
AmericasRegent Seven Seas Cruises
Carnival Of Caribbean Colors
Aboard Seven Seas Grandeur
Panama City → Panama Canal Transit → Cartagena → Santa Marta +11 more
14 nights · 1 departure
Port-rich · 15 ports
AmericasRegent Seven Seas Cruises
Crescent Beaches & Colorful Towns
Aboard Seven Seas Prestige
Panama City → Panama Canal Transit → Puerto Limón → Cruising the Caribbean Sea +8 more
11 nights · 1 departure
Port-rich · 12 ports
AmericasDisney Cruise Line
14-Night Eastbound Panama Canal Cruise from San Diego ending in Galveston
Aboard Disney Magic
San Diego, California → At Sea → Cabo San Lucas → Puerto Vallarta +4 more
14 nights · 1 departure
Balanced · 8 ports
AmericasHolland America Line
15-Day Panama Canal
Aboard Zuiderdam
San Diego, California → Puerto Vallarta → Huatulco (Santa María Huatulco) → Puerto Chiapas +5 more
15 nights · 1 departure
Balanced · 9 ports
Frequently asked
- How many Panama Canal cruises does NestCruise have?
- 96 live sailings, 11 to 22 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines run Panama Canal cruises?
- Regent Seven Seas Cruises, Holland America Line, Oceania Cruises and Norwegian Cruise Line, among others.
- How long are Panama Canal cruises?
- Most run 11 to 22 nights.
- How much do Panama Canal cruises cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.