Cruise itinerary
16-Night Americas Cruise from Miami, Florida
16 nights · Americas · 9 ports of call
16-night Americas cruise aboard Brilliant Lady, departing Miami, Florida and calling at At Sea, Cartagena, Colón, Panama Canal Transit, Puntarenas and Puerto Quetzal and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Brilliant Lady
- Cruise line
- Virgin Voyages
- Duration
- 16 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- Los Angeles, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Brilliant Lady sailing, typically within 24 hours.
Where this voyage takes you
- Adults Only
Day-by-day itinerary
- Day1
Miami, Florida
Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
At Sea
- Day3
At Sea
- Day4
Cartagena
Arrive 09:00 · Depart 17:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day5
Colón
Arrive 10:00 · Depart 19:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day6
Panama Canal Transit
Arrive 00:00
- Day7
At Sea
- Day8
Puntarenas
Arrive 09:00 · Depart 18:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day9
At Sea
- Day10
Puerto Quetzal
Arrive 08:00 · Depart 17:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day11
At Sea
- Day12
At Sea
- Day13
At Sea
- Day14
Cabo San Lucas
Arrive 08:00 · Depart 17:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day15
At Sea
- Day16
At Sea
- Day17
Los Angeles, California
Arrive 06:30
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
Upcoming departures
- 26 Mar 2027
- 21 Feb 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 16-night Americas cruise calls at Miami, Florida, At Sea, Cartagena, Colón, Panama Canal Transit, Puntarenas, Puerto Quetzal, Cabo San Lucas and Los Angeles, California.
How many days are spent at sea?
9 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in Los Angeles, California.
How long is this cruise?
16 nights aboard Brilliant Lady.
When does this itinerary sail?
Upcoming departures include 26 Mar 2027 and 21 Feb 2028. A NestCruise advisor can confirm current availability.