Cruise itinerary
16-Night Americas Cruise from Miami, Florida
16 nights · Americas · 12 ports of call
16-night Americas cruise aboard Seven Seas Splendor, departing Miami, Florida and calling at Cruising the Bahamian Waters, Ocho Rios, Cruising the Caribbean Sea, Cartagena, Panama Canal Transit and Cruising the Pacific Ocean and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 16 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- San Francisco, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Splendor sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 16:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Cruising the Bahamian Waters
- Day3
Ocho Rios
Arrive 11:00 · Depart 18:00
A resort town on Jamaica's north coast, set among green hills and a string of beaches. The terraced cascades of Dunn's River Falls are the headline attraction, with botanical gardens, river tubing and reggae-filled markets close to the cruise pier.
- Dunn's River Falls
- Resort beaches
- Botanical gardens
- Day4
Cruising the Caribbean Sea
- Day5
Cartagena
Arrive 07:00 · Depart 13:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day6
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day7
Cruising the Pacific Ocean
- Day8
Puntarenas
Arrive 08:00 · Depart 17:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day9
Cruising the Pacific Ocean
- Day10
Puerto Quetzal
Arrive 07:00 · Depart 16:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day11
Cruising the Pacific Ocean
- Day12
Cruising the Pacific Ocean
- Day13
Puerto Vallarta
Arrive 07:00 · Depart 14:30
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day14
Cabo San Lucas
Arrive 07:00 · Depart 14:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day15
Cruising the Pacific Ocean
- Day16
Cruising the Pacific Ocean
- Day17
San Francisco, California
Arrive 08:00
A hill-built city on a peninsula between the Pacific and San Francisco Bay, known for the Golden Gate Bridge, cable cars, and Victorian rowhouses. Ships dock near the Embarcadero, within reach of Fisherman's Wharf, Chinatown, and ferries to Alcatraz.
- Golden Gate Bridge
- Cable cars
- Alcatraz Island
Upcoming departures
- 20 Dec 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 16-night Americas cruise calls at Miami, Florida, Cruising the Bahamian Waters, Ocho Rios, Cruising the Caribbean Sea, Cartagena, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Puerto Quetzal, Puerto Vallarta, Cabo San Lucas and San Francisco, California.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in San Francisco, California.
How long is this cruise?
16 nights aboard Seven Seas Splendor.
When does this itinerary sail?
Upcoming departures include 20 Dec 2027. A NestCruise advisor can confirm current availability.