Cruises to Santarém
28 live cruises call at Santarém — 19 to 121 nights, departing 11 ports, across 6 lines. A NestCruise advisor narrows them to the one that fits.
AmericasExplora Journeys
A Journey through Coastal History & the Heart of the Amazon
Aboard EXPLORA II
San Juan (Puerto Rico) → Little Bay → Bridgetown → At Sea +5 more
11 nights · 1 departure
Port-rich · 9 ports
AmericasCrystal
Fort Lauderdale to Manaus (Amazon)
Aboard Crystal Symphony
Fort Lauderdale, Florida → At Sea → Gustavia → Fort-de-France +5 more
12 nights · 1 departure
Balanced · 9 ports
AmericasExplora Journeys
A Journey of Amazon Exploration & Cultural Discovery
Aboard EXPLORA I
San Juan (Puerto Rico) → Gustavia → Saint Pierre → Bridgetown +6 more
12 nights · 1 departure
Port-rich · 10 ports
AmericasSilversea
Rio de Janeiro to Bridgetown
Aboard Silver Ray
Rio de Janeiro → At Sea → Salvador de Bahia → Fortaleza +8 more
20 nights · 1 departure
Balanced · 12 ports
AmericasOceania Cruises
Amazonian Spirit
Aboard Oceania Insignia
Rio de Janeiro → At Sea → Cruising Amazon River → Alter do Chão +8 more
21 nights · 1 departure
Balanced · 12 ports
AmericasRegent Seven Seas Cruises
Secrets Of The Selva
Aboard Seven Seas Voyager
Rio de Janeiro → Sailing the Atlantic Ocean → Recife → Alter do Chão +8 more
21 nights · 1 departure
Balanced · 12 ports
AmericasOceania Cruises
Amazonian Exploration
Aboard Oceania Sirena
Rio de Janeiro → At Sea → Maceió → Cruising Amazon River +9 more
21 nights · 1 departure
Balanced · 13 ports
AmericasRegent Seven Seas Cruises
Secrets Of The Amazon
Aboard Seven Seas Mariner
Miami, Florida → Sailing the Atlantic Ocean → Bridgetown → Port-of-Spain +9 more
22 nights · 1 departure
Balanced · 13 ports
AmericasCrystal
Roundtrip Fort Lauderdale
Aboard Crystal Serenity
Fort Lauderdale, Florida → At Sea → Road Town, Tortola → Pointe-à-Pitre +11 more
25 nights · 1 departure
Balanced · 15 ports
AmericasHolland America Line
27-Day Legendary Amazon Explorer
Aboard Volendam
Fort Lauderdale, Florida → Sint Maarten → Fort-de-France → Bridgetown +9 more
27 nights · 1 departure
Sea-paced · 13 ports
AmericasHolland America Line
28-Day Legendary Amazon Explorer
Aboard Zuiderdam
Fort Lauderdale, Florida → Half Moon Cay → Sint Maarten → Fort-de-France +12 more
28 nights · 1 departure
Balanced · 16 ports
AmericasCrystal
Roundtrip Fort Lauderdale
Aboard Crystal Symphony
Fort Lauderdale, Florida → At Sea → Gustavia → Fort-de-France +11 more
25 nights · 1 departure
Balanced · 15 ports
World CruiseExplora Journeys
An Extended Journey of Caribbean Charms & Amazonian Wonders
Aboard EXPLORA I
Miami, Florida → At Sea → Puerto Plata → Philipsburg +11 more
19 nights · 1 departure
Port-rich · 15 ports
AmericasOceania Cruises
Amazon & Caribbean Isles
Aboard Oceania Insignia
Miami, Florida → At Sea → Tortola → Saint John's +13 more
25 nights · 1 departure
Balanced · 17 ports
World CruiseRegent Seven Seas Cruises
Grand South America Mosaic
Aboard Seven Seas Voyager
Miami, Florida → Cruising the Florida Straits → Georgetown, Grand Cayman → Falmouth +36 more
65 nights · 1 departure
Balanced · 40 ports
World CruiseOceania Cruises
South American Adventure
Aboard Oceania Sirena
Miami, Florida → At Sea → Georgetown, Grand Cayman → Ocho Rios +33 more
65 nights · 1 departure
Balanced · 37 ports
AmericasRegent Seven Seas Cruises
Rio's Belle Poque
Aboard Seven Seas Mariner
Miami, Florida → Sailing the Atlantic Ocean → Bridgetown → Cruising the Amazon Central River, Brazil +9 more
25 nights · 1 departure
Balanced · 13 ports
AmericasHolland America Line
30-Day Legendary Amazon Explorer
Aboard Volendam
New York, New York → Fort Lauderdale, Florida → Sint Maarten → Fort-de-France +10 more
30 nights · 1 departure
Sea-paced · 14 ports
World CruiseCrystal
Melbourne to Fort Lauderdale
Aboard Crystal Symphony
Melbourne, Victoria → Portland, Victoria → Kangaroo Island, South Australia → Adelaide, South Australia +67 more
121 nights · 1 departure
Balanced · 71 ports
AmericasExplora Journeys
An Extended Journey into Island Elegance & Mysteries of the Amazon
Aboard EXPLORA I
San Juan (Puerto Rico) → Gustavia → Saint Pierre → Bridgetown +12 more
24 nights · 1 departure
Balanced · 16 ports
PacificOceania Cruises
Brazil Unbound
Aboard Oceania Insignia
Buenos Aires → Montevideo → Punta del Este → Rio Grande +18 more
33 nights · 1 departure
Balanced · 22 ports
World CruiseRegent Seven Seas Cruises
Eras Of Exploration
Aboard Seven Seas Mariner
Miami, Florida → Sailing the Atlantic Ocean → Bridgetown → Cruising the Amazon Central River, Brazil +89 more
150 nights · 1 departure
Balanced · 93 ports
World CruiseCrystal
Melbourne to New York City
Aboard Crystal Symphony
Melbourne, Victoria → Portland, Victoria → Kangaroo Island, South Australia → Adelaide, South Australia +69 more
127 nights · 1 departure
Balanced · 73 ports
CaribbeanOceania Cruises
Amazon & Tropical Isles
Aboard Oceania Insignia
Lisbon → At Sea → Arrecife, Lanzarote → Las Palmas de Gran Canaria +17 more
40 nights · 1 departure
Balanced · 21 ports
World CruiseCrystal
Melbourne to Portsmouth
Aboard Crystal Symphony
Melbourne, Victoria → Portland, Victoria → Kangaroo Island, South Australia → Adelaide, South Australia +78 more
141 nights · 1 departure
Balanced · 82 ports
MediterraneanOceania Cruises
Footsteps Of Columbus
Aboard Oceania Insignia
Barcelona → Palma de Mallorca → Alicante → Cartagena +24 more
47 nights · 1 departure
Balanced · 28 ports
Frequently asked
- How many cruises to Santarém does NestCruise have?
- 28 live sailings, 19 to 121 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines visit Santarém?
- Oceania Cruises, Crystal, Regent Seven Seas Cruises and Explora Journeys, among others.
- How long are cruises to Santarém?
- Most run 19 to 121 nights.
- How much do cruises to Santarém cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.