Cruise itinerary
22-Night Americas Cruise from Miami, Florida
22 nights · Americas · 13 ports of call
22-night Americas cruise aboard Seven Seas Mariner, departing Miami, Florida and calling at Sailing the Atlantic Ocean, Bridgetown, Port-of-Spain, Cruising Amazon River, Santarém and Boca de Valeria and 6 more.
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- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 22 nights
- Region
- Americas · South America
- Departs
- Miami, Florida
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Mariner sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Sailing the Atlantic Ocean
- Day3
Sailing the Atlantic Ocean
- Day4
Sailing the Atlantic Ocean
- Day5
Bridgetown
Arrive 09:00 · Depart 17:00
The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
- Carlisle Bay
- Garrison Savannah
- Rum distilleries
- Day6
Port-of-Spain
Arrive 07:00 · Depart 16:00
- Day7
Sailing the Atlantic Ocean
- Day8
Sailing the Atlantic Ocean
- Day9
Cruising Amazon River
- Day10
Santarém
Arrive 09:00 · Depart 18:00
- Day11
Boca de Valeria
Arrive 07:00 · Depart 15:00
- Day12
Manaus
Arrive 09:00 · Depart 17:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day13
Parintins
Arrive 11:00 · Depart 19:00
- Day14
Alter do Chão
Arrive 07:00 · Depart 15:00
- Day15
Cruising Amazon River
- Day16
Sailing the Atlantic Ocean
- Day17
Sailing the Atlantic Ocean
- Day18
Saint George's
Arrive 11:30 · Depart 20:30
The capital of Grenada in the eastern Caribbean, set around a horseshoe harbour ringed by red-roofed houses. Known as the Spice Isle for its nutmeg, the island offers Grand Anse beach, hillside Fort George and rainforest waterfalls inland.
- Grand Anse Beach
- Fort George
- Nutmeg plantations
- Day19
Cruising the Caribbean Sea
- Day20
San Juan (Puerto Rico)
Arrive 07:00 · Depart 20:00
The capital of Puerto Rico and a major Caribbean homeport. Old San Juan's pastel colonial streets sit behind the massive El Morro and San Cristóbal forts, with rum distilleries and the beaches of Condado close to the cruise piers.
- Old San Juan
- El Morro fort
- Condado beaches
- Day21
Sailing the Atlantic Ocean
- Day22
Sailing the Atlantic Ocean
- Day23
Miami, Florida
Arrive 06:00 · Depart 19:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 9 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 22-night Americas cruise calls at Miami, Florida, Sailing the Atlantic Ocean, Bridgetown, Port-of-Spain, Cruising Amazon River, Santarém, Boca de Valeria, Manaus, Parintins, Alter do Chão, Saint George's, Cruising the Caribbean Sea and San Juan (Puerto Rico).
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Miami, Florida.
How long is this cruise?
22 nights aboard Seven Seas Mariner.
When does this itinerary sail?
Upcoming departures include 9 Nov 2026. A NestCruise advisor can confirm current availability.