Cruise itinerary
65-Night World Cruise Cruise from Miami, Florida
65 nights · World Cruise · 37 ports of call
65-night World Cruise cruise aboard Oceania Sirena, departing Miami, Florida and calling at At Sea, Georgetown, Grand Cayman, Ocho Rios, Santa Marta, Cartagena and Colón and 30 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Sirena
- Cruise line
- Oceania Cruises
- Duration
- 65 nights
- Region
- World Cruise
- Departs
- Miami, Florida
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Sirena sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
At Sea
- Day3
Georgetown, Grand Cayman
Arrive 11:00 · Depart 18:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day4
Ocho Rios
Arrive 11:00 · Depart 20:00
A resort town on Jamaica's north coast, set among green hills and a string of beaches. The terraced cascades of Dunn's River Falls are the headline attraction, with botanical gardens, river tubing and reggae-filled markets close to the cruise pier.
- Dunn's River Falls
- Resort beaches
- Botanical gardens
- Day5
At Sea
- Day6
Santa Marta
Arrive 07:00 · Depart 17:00
- Day7
Cartagena
Arrive 07:00 · Depart 13:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day8
Colón
Arrive 08:00 · Depart 20:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day9
Panama Canal Transit
Arrive 06:00 · Depart 18:00
- Day10
At Sea
- Day11
Manta
Arrive 07:00 · Depart 17:00
- Day12
At Sea
- Day13
Salaverry
Arrive 07:00 · Depart 16:00
- Day14
Callao
Arrive 11:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day15
Callao
Arrive 07:00 · Depart 17:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day16
Pisco
Arrive 08:00 · Depart 17:00
- Day17
At Sea
- Day18
Arica
Arrive 07:00 · Depart 17:00
- Day19
At Sea
- Day20
Antofagasta
Arrive 07:00 · Depart 17:00
- Day21
At Sea
- Day22
Valparaiso
Arrive 07:00 · Depart 16:00
A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
- Hillside funiculars
- Cerro Concepción
- Casablanca wineries
- Day23
At Sea
- Day24
Puerto Montt
Arrive 09:00 · Depart 18:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day25
Castro
Arrive 07:00 · Depart 16:00
- Day26
Puerto Chacabuco
Arrive 09:00 · Depart 18:00
- Day27
Cruising the Chilean Fjords
- Day28
Cruising the Chilean Fjords
- Day29
Punta Arenas
Arrive 07:00 · Depart 17:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day30
Ushuaia
Arrive 11:00 · Depart 20:00
The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
- Beagle Channel
- Tierra del Fuego park
- End of the world
- Day31
At Sea
- Day32
At Sea
- Day33
Sailing along the Antarctic Peninsula
Arrive 08:00 · Depart 10:00
- Day34
Sailing along the Antarctic Peninsula
Arrive 13:00 · Depart 14:00
- Day35
At Sea
- Day36
Port Stanley
Arrive 07:00 · Depart 16:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day37
At Sea
- Day38
Puerto Madryn
Arrive 08:00 · Depart 17:00
A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
- Península Valdés
- Whale watching
- Welsh heritage
- Day39
At Sea
- Day40
At Sea
- Day41
Buenos Aires
Arrive 05:00 · Depart 18:00
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day42
Punta del Este
Arrive 08:00 · Depart 18:00
- Day43
At Sea
- Day44
At Sea
- Day45
Rio de Janeiro
Arrive 07:00 · Depart 17:00
Brazil's great coastal city, set between forested mountains and the Atlantic. The Christ the Redeemer statue looks down from Corcovado, Sugarloaf rises over the harbour mouth, and the sands of Copacabana and Ipanema run along the city's southern edge.
- Christ the Redeemer
- Sugarloaf Mountain
- Copacabana Beach
- Day46
At Sea
- Day47
At Sea
- Day48
Maceió
Arrive 07:00 · Depart 17:00
The capital of Alagoas on Brazil's north-east coast, fringed by white sand and warm reef-protected lagoons. Pajuçara and Ponta Verde beaches draw swimmers, and jangada rafts carry visitors out to the natural tidal pools offshore.
- Pajuçara beach
- Natural pools
- Jangada rafts
- Day49
At Sea
- Day50
At Sea
- Day51
At Sea
- Day52
Cruising Amazon River
- Day53
Santarém
Arrive 08:00 · Depart 17:00
- Day54
Boca de Valeria
Arrive 07:00 · Depart 14:00
- Day55
Manaus
Arrive 09:00 · Depart 17:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day56
Parintins
Arrive 10:00 · Depart 18:00
- Day57
Alter do Chão
Arrive 07:00 · Depart 13:00
- Day58
At Sea
- Day59
At Sea
- Day60
At Sea
- Day61
Bridgetown
Arrive 09:00 · Depart 17:00
The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
- Carlisle Bay
- Garrison Savannah
- Rum distilleries
- Day62
Pointe-à-Pitre
Arrive 09:00 · Depart 17:00
The main town of Guadeloupe, a French overseas region in the eastern Caribbean shaped like a butterfly. It sits between the two wings of the island, with a covered spice market, Creole cooking and the volcano of La Soufrière to the south.
- Spice market
- La Soufrière
- Memorial ACTe
- Day63
Tortola
Arrive 10:00 · Depart 17:00
The main island of the British Virgin Islands, where steep green hills drop to a yacht-filled harbour at Road Town. It is a noted sailing base in the Caribbean, with quiet bays such as Cane Garden and ferries out to neighbouring Virgin Gorda.
- Road Town
- Cane Garden Bay
- Sailing charters
- Day64
At Sea
- Day65
At Sea
- Day66
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 5 Jan 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
65-Night World Cruise Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 65-night World Cruise cruise calls at Miami, Florida, At Sea, Georgetown, Grand Cayman, Ocho Rios, Santa Marta, Cartagena, Colón, Panama Canal Transit, Manta, Salaverry, Callao, Pisco, Arica, Antofagasta, Valparaiso, Puerto Montt, Castro, Puerto Chacabuco, Cruising the Chilean Fjords, Punta Arenas, Ushuaia, Sailing along the Antarctic Peninsula, Port Stanley, Puerto Madryn, Buenos Aires, Punta del Este, Rio de Janeiro, Maceió, Cruising Amazon River, Santarém, Boca de Valeria, Manaus, Parintins, Alter do Chão, Bridgetown, Pointe-à-Pitre and Tortola.
How many days are spent at sea?
29 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Miami, Florida.
How long is this cruise?
65 nights aboard Oceania Sirena.
When does this itinerary sail?
Upcoming departures include 5 Jan 2028. A NestCruise advisor can confirm current availability.