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Cruises to San Diego

131 live cruises call at San Diego — 4 to 36 nights, departing 17 ports, across 13 lines. A NestCruise advisor narrows them to the one that fits.

131 sailings
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Catalina & Ensenada CruiseAmericas

Royal Caribbean International

4 nights: Ensenada

Aboard Serenade of the Seas

Round-trip from San Diego

from$219pp · cruise fare≈ $55/night pp

Fares checked nightly

Sails weekly, Nov 2026 – Apr 2027
MEXICAN RIVIERABAJA

Disney Cruise Line

4 nights: Ensenada

Aboard Disney Wonder

Round-trip from San Diego

Sails every two weeks, Nov 2026 – Apr 2027
7-Day Mexican Riviera Round-trip San Diego: Cabo San Lucas & MazatlánMexican Riviera

Norwegian Cruise Line

7 nights: Cabo San Lucas & Puerto Vallarta, the Mexican Riviera

Aboard Norwegian Star

Round-trip from San Diego

↓ $249 this monthPast Guest Offer

from$449pp · cruise fare≈ $64/night pp

Fares checked nightly

Sails weekly, Dec 2026 – Feb 2027
7-Day Baja PeninsulaAmericas

Holland America Line

7 nights: Cabo San Lucas, South America

Aboard Koningsdam

Round-trip from San Diego

Nov 2026 – Nov 2027Next 21 Nov 2026 · 5 more
Classic California CoastWest Coast US

Princess Cruises

7 nights: Ensenada

Aboard Emerald Princess

Round-trip from Los Angeles

Nov 2026 – Apr 2027Next 1 Nov 2026 · 4 more
7-Day Mexican RivieraAmericas

Holland America Line

7 nights: Cabo San Lucas, South America

Aboard Zaandam

Round-trip from San Diego

Rare itinerary
Mar 2027 – Oct 2027Next 28 Mar 2027 · 1 more
16-Day Panama CanalAmericas

Holland America Line

16 nights: Cabo San Lucas & Aruba, South America

Aboard Eurodam

San Diego → Fort Lauderdale

Rare itinerary
Oct 2027 – Apr 2028Next 7 Oct 2027 · 1 more
5-Day Pacific Coastal CruisePacific

Holland America Line

5 nights: Vancouver

Aboard Nieuw Amsterdam

Vancouver → San Diego

Rare itinerary
Oct 2027Next 7 Oct 2027
Classic California CoastWest Coast US

Princess Cruises

7 nights: Ensenada

Aboard Crown Princess

Round-trip from Los Angeles

Rare itinerary
Sails weekly, Oct 2027
Classic California CoastWest Coast US

Princess Cruises

7 nights: Ensenada

Aboard Ruby Princess

Round-trip from San Francisco

Rare itinerary
Mar 2028Next 19 Mar 2028
Pacific Coastal: Vancouver to LAAmericas

Virgin Voyages

8 nights: Vancouver

Aboard Brilliant Lady

Vancouver → Los Angeles

↓ $842 this monthOvernight in Vancouver

from$2,238pp · cruise fare≈ $280/night pp

Fares checked nightly

Sep 2027Next 10 Sep 2027
Roundtrip San DiegoAmericas

Crystal

The South America loop

Aboard Crystal Serenity

Round-trip from San Diego

Rare itinerary

from$5,600pp · cruise fare≈ $622/night pp

Fares checked nightly

Dec 2026Next 21 Dec 2026 · 1 more
18-Night Panama Canal CruisePanama Canal

MSC Cruises

18 nights: Cabo San Lucas & Seattle, the Panama Canal

Aboard MSC Poesia

Miami → Seattle

Rare itinerary
Apr 2027 – Apr 2028Next 8 Apr 2027 · 1 more
West Coast Getaway with San DiegoWest Coast US

Princess Cruises

4 nights: Ensenada

Aboard Discovery Princess

Round-trip from Los Angeles

Rare itinerary
Dec 2027Next 18 Dec 2027
CALIFORNIA COASTALASKA N A

Disney Cruise Line

4 nights: Vancouver

Aboard Disney Magic

San Diego → Vancouver

Rare itinerary
May 2027Next 9 May 2027
6-Day Pacific Coastal CruisePacific

Holland America Line

6 nights: Seattle & Vancouver

Aboard Oosterdam

San Diego → Vancouver

Rare itinerary
Apr 2028Next 22 Apr 2028
Pacific Coast Cruise: Vancouver, Seattle & San FranciscoAmericas

Azamara

7 nights: Seattle

Aboard Azamara Quest

Vancouver Island → San Diego

Rare itinerary

from$9,739pp · cruise fare≈ $1,391/night pp

Fares checked nightly

May 2027Next 17 May 2027
7-Day Baja PeninsulaAmericas

Holland America Line

7 nights: Cabo San Lucas, South America

Aboard Zuiderdam

Round-trip from San Diego

Rare itinerary
Jan 2027Next 23 Jan 2027
San Diego to VancouverAmericas

Crystal

8 nights: Juneau & Skagway, Alaska

Aboard Crystal Symphony

San Diego → Vancouver

Overnight in San FranciscoRare itinerary

from$4,200pp · cruise fare≈ $525/night pp

Fares checked nightly

Jun 2028Next 25 Jun 2028
Amador (Panama City) → Los AngelesCentral & North America Pacific Coast

Explora Journeys

11 nights: Puerto Vallarta & Vancouver

Aboard EXPLORA III

Panama City → Vancouver

↓ $3,185 this monthWinter 2026-2027

from$5,915pp · cruise fare≈ $538/night pp

Fares checked nightly

Apr 2027Next 22 Apr 2027
Pacific Crossing: Honolulu to British ColumbiaHawaii

Princess Cruises

12 nights: Honolulu & Vancouver, the Hawaiian Islands

Aboard Royal Princess

Honolulu → Vancouver

Rare itinerary
Apr 2027Next 16 Apr 2027
Treasures Of Two OceansAmericas

Oceania Cruises

15 nights in South America

Aboard Oceania Vista

Miami → Los Angeles

Rare itinerary
Jan 2027Next 6 Jan 2027
Panama Canal & Pacific GemsAmericas

Regent Seven Seas Cruises

16 nights: Cabo San Lucas, South America

Aboard Seven Seas Grandeur

Miami → Los Angeles

Rare itinerary
Dec 2026Next 29 Dec 2026
18-Night Polynesia CruisePolynesia

Silversea

18 nights: Puerto Vallarta & Honolulu, French Polynesia

Aboard Silver Dawn

Miami → Papeete

Overnight in PapeeteRare itinerary
Dec 2026Next 21 Dec 2026
World Cruise 2029World Cruise

Silversea

18 nights: Honolulu & Tokyo

Aboard Silver Whisper

San Diego → Singapore

Overnight in HonoluluRare itinerary

from$14,600pp · cruise fare≈ $811/night pp

Fares checked nightly

Jan 2029Next 5 Jan 2029
Circle Pacific Liner (Sydney to Tokyo)Pacific

Princess Cruises

57 nights: Honolulu & Juneau

Aboard Grand Princess

Round-trip from Sydney

Overnight in Halong BayRare itinerary
Jun 2028Next 17 Jun 2028
Ensenada CruiseAmericas

Royal Caribbean International

3 nights: Ensenada

Aboard Serenade of the Seas

Round-trip from San Diego

from$219pp · cruise fare≈ $73/night pp

Fares checked nightly

Dec 2026 – Apr 2027Next 3 Dec 2026 · 13 more
MEXICAN RIVIERABAJA

Disney Cruise Line

3 nights: Ensenada

Aboard Disney Wonder

Round-trip from San Diego

Nov 2026 – Feb 2027Next 2 Nov 2026 · 5 more
6-Day Mexican Riviera Round-trip San Diego: Cabo & Puerto VallartaMexican Riviera

Norwegian Cruise Line

6 nights: Puerto Vallarta & Cabo San Lucas, the Mexican Riviera

Aboard Norwegian Star

Round-trip from San Diego

↓ $299 this monthPast Guest Offer

from$479pp · cruise fare≈ $80/night pp

Fares checked nightly

Dec 2026Next 20 Dec 2026
7-Day Mexican RivieraAmericas

Holland America Line

7 nights: Cabo San Lucas & Puerto Vallarta, South America

Aboard Koningsdam

Round-trip from San Diego

Dec 2026 – Apr 2028Next 26 Dec 2026 · 5 more
West Coast Getaway with San DiegoWest Coast US

Princess Cruises

4 nights: Ensenada

Aboard Emerald Princess

Round-trip from Los Angeles

Rare itinerary
Nov 2026 – Oct 2027Next 24 Nov 2026 · 1 more
12-Day Historical Baja PeninsulaAmericas

Holland America Line

12 nights: Cabo San Lucas & Puerto Vallarta, South America

Aboard Zaandam

Round-trip from San Diego

Rare itinerary
Dec 2026 – Dec 2027Next 7 Dec 2026 · 2 more
20-Day Panama CanalAmericas

Holland America Line

20 nights: Vancouver & Cabo San Lucas, South America

Aboard Eurodam

Vancouver → Fort Lauderdale

Rare itinerary
Apr 2027 – Oct 2027Next 3 Apr 2027 · 1 more
21-Day Panama CanalAmericas

Holland America Line

21 nights: Vancouver & Puerto Vallarta, South America

Aboard Nieuw Amsterdam

Vancouver → Fort Lauderdale

Rare itinerary
Apr 2027Next 11 Apr 2027
West Coast Getaway with Santa BarbaraWest Coast US

Princess Cruises

5 nights: Ensenada

Aboard Crown Princess

Round-trip from Los Angeles

Rare itinerary
Nov 2027Next 23 Nov 2027
West Coast Getaway with San Diego HolidayWest Coast US

Princess Cruises

5 nights: Ensenada

Aboard Ruby Princess

Round-trip from San Francisco

Rare itinerary
Nov 2027Next 23 Nov 2027
Baja Mexico Halloween CruiseAmericas

Virgin Voyages

7 nights: Ensenada & Cabo San Lucas, South America

Aboard Brilliant Lady

Round-trip from Los Angeles

Rare itinerary
Oct 2027Next 30 Oct 2027
Vancouver to San DiegoCaribbean

Crystal

7 nights: Vancouver & Puerto Vallarta, the Caribbean

Aboard Crystal Serenity

Vancouver → New York

Overnight in CartagenaRare itinerary

from$4,700pp · cruise fare≈ $671/night pp

Fares checked nightly

Aug 2027Next 2 Aug 2027
19-Night Panama Canal CruisePanama Canal

MSC Cruises

19 nights: Seattle & Cabo San Lucas, the Panama Canal

Aboard MSC Poesia

Seattle → Miami

Rare itinerary
Sep 2027Next 27 Sep 2027
TRANS PANAMA CANALPANAMA CANAL W

Disney Cruise Line

14 nights: Cozumel & Cabo San Lucas

Aboard Disney Magic

Galveston → San Diego

Rare itinerary
Apr 2027Next 25 Apr 2027
15-Day Panama CanalAmericas

Holland America Line

15 nights: Aruba & Cabo San Lucas, South America

Aboard Oosterdam

Fort Lauderdale → San Diego

Rare itinerary
Apr 2028Next 7 Apr 2028
Panama Canal & Latin America Cruise: Mexico, Costa Rica & ColombiaAmericas

Azamara

17 nights: Cabo San Lucas, South America

Aboard Azamara Quest

San Diego → Miami

Overnight in CartagenaRare itinerary

from$4,159pp · cruise fare≈ $245/night pp

Fares checked nightly

May 2027Next 24 May 2027
7-Day Mexican RivieraAmericas

Holland America Line

7 nights: Cabo San Lucas, South America

Aboard Zuiderdam

Round-trip from San Diego

Rare itinerary
Jan 2027Next 16 Jan 2027
Fort Lauderdale to San DiegoAmericas

Crystal

15 nights: Juneau & Skagway, South America

Aboard Crystal Symphony

Fort Lauderdale → Vancouver

Overnight in CartagenaRare itinerary

from$5,700pp · cruise fare≈ $380/night pp

Fares checked nightly

Jun 2028Next 10 Jun 2028
Los Angeles → VancouverGrand Journeys

Explora Journeys

18 nights: Juneau & Skagway

Aboard EXPLORA III

Los Angeles → Vancouver

↓ $5,175 this monthWinter 2026-2027

from$12,075pp · cruise fare≈ $671/night pp

Fares checked nightly

May 2027Next 3 May 2027
Pacific Crossing: Honolulu to British ColumbiaHawaii

Princess Cruises

13 nights: Honolulu & Vancouver, the Hawaiian Islands

Aboard Royal Princess

Honolulu → Vancouver

Rare itinerary
Apr 2028Next 12 Apr 2028
Continental ExplorerWorld Cruise

Oceania Cruises

127 nights: Honolulu & Singapore

Aboard Oceania Vista

Miami → Doha

Overnight in CairnsRare itinerary
Jan 2027Next 6 Jan 2027
Circle Pacific (Roundtrip Auckland)Pacific

Princess Cruises

93 nights: Honolulu & Juneau

Aboard Grand Princess

Round-trip from Auckland

Overnight in Halong BayRare itinerary
Jun 2028Next 22 Jun 2028

Frequently asked

How many cruises to San Diego does NestCruise have?
131 live sailings, 4 to 36 nights. A NestCruise advisor narrows them to the one that fits.
Which cruise lines visit San Diego?
Holland America Line, Princess Cruises, Disney Cruise Line and Royal Caribbean International, among others.
How long are cruises to San Diego?
Most run 4 to 36 nights.
How much do cruises to San Diego cost?
NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.