Cruise itinerary
16-Night Americas Cruise from Miami, Florida
16 nights · Americas · 13 ports of call
16-night Americas cruise aboard Seven Seas Grandeur, departing Miami, Florida and calling at Cruising the Florida Straits, Georgetown, Grand Cayman, Cruising the Caribbean Sea, Cartagena, Panama Canal Transit and Cruising the Pacific Ocean and 6 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 16 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- Los Angeles, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Cruising the Florida Straits
- Day3
Georgetown, Grand Cayman
Arrive 09:00 · Depart 16:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day4
Cruising the Caribbean Sea
- Day5
Cartagena
Arrive 07:00 · Depart 14:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day6
Panama Canal Transit
Arrive 07:00 · Depart 18:00
- Day7
Cruising the Pacific Ocean
- Day8
Puntarenas
Arrive 06:00 · Depart 19:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day9
Cruising the Pacific Ocean
- Day10
Puerto Quetzal
Arrive 07:00 · Depart 19:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day11
Cruising the Pacific Ocean
- Day12
Acapulco
Arrive 08:00 · Depart 17:00
- Day13
Cruising the Pacific Ocean
- Day14
Cabo San Lucas
Arrive 10:00 · Depart 18:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day15
Cruising the Pacific Ocean
- Day16
San Diego, California
Arrive 12:00 · Depart 22:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day17
Los Angeles, California
Arrive 07:00 · Depart 17:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
Upcoming departures
- 29 Dec 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 16-night Americas cruise calls at Miami, Florida, Cruising the Florida Straits, Georgetown, Grand Cayman, Cruising the Caribbean Sea, Cartagena, Panama Canal Transit, Cruising the Pacific Ocean, Puntarenas, Puerto Quetzal, Acapulco, Cabo San Lucas, San Diego, California and Los Angeles, California.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in Los Angeles, California.
How long is this cruise?
16 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 29 Dec 2026. A NestCruise advisor can confirm current availability.