Cruise itinerary
17-Night Americas Cruise from San Diego, California
17 nights · Americas · 9 ports of call
17-night Americas cruise aboard Azamara Quest, departing San Diego, California and calling at Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas and Panama Canal Transit and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Azamara Quest
- Cruise line
- Azamara
- Duration
- 17 nights
- Region
- Americas · South America · Panama Canal
- Departs
- San Diego, California
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Azamara Quest sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
Depart 20:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2At sea
- Day3At sea
- Day4
Cabo San Lucas
Arrive 8:00 · Depart 17:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day5At sea
- Day6
Acapulco
Arrive 13:00 · Depart 20:00
- Day7At sea
- Day8
Puerto Quetzal
Arrive 9:30 · Depart 20:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day9
Acajutla
Arrive 8:00 · Depart 18:00
- Day10At sea
- Day11
Puntarenas
Arrive 8:00 · Depart 21:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day12At sea
- Day13
Panama Canal Transit
Arrive 5:00 · Depart 17:00
- Day14
Cartagena
Arrive 13:30
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day15
Cartagena
Depart 6:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day16At sea
- Day17At sea
- Day18
Miami, Florida
Arrive 6:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 24 May 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
17-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 17-night Americas cruise calls at San Diego, California, Cabo San Lucas, Acapulco, Puerto Quetzal, Acajutla, Puntarenas, Panama Canal Transit, Cartagena and Miami, Florida.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in Miami, Florida.
How long is this cruise?
17 nights aboard Azamara Quest.
When does this itinerary sail?
Upcoming departures include 24 May 2027. A NestCruise advisor can confirm current availability.