Cruises from San Diego, California
92 live cruises sail from San Diego, California — 4 to 31 nights, across 8 lines, through Transpacific. A NestCruise advisor narrows them to the one that fits.
AmericasDisney Cruise Line
3-Night Baja Cruise from San Diego
Aboard Disney Wonder
San Diego, California → Ensenada → At Sea
3 nights · 6 departures
Balanced · 3 ports
AmericasRoyal Caribbean International
3 Night Ensenada Cruise
Aboard Serenade of the Seas
San Diego, California → Ensenada
3 nights · 6 departures
Sea-paced · 2 ports
AmericasNorwegian Cruise Line
Mexican Riviera: Cabo San Lucas & Puerto Vallarta
Aboard Norwegian Star
San Diego, California → Cabo San Lucas → Mazatlán → Puerto Vallarta
7 nights · 6 departures
Sea-paced · 4 ports
AmericasHolland America Line
7-Day Baja Peninsula
Aboard Koningsdam
San Diego, California → Cabo San Lucas → La Paz → Loreto
7 nights · 5 departures
Sea-paced · 4 ports
AmericasDisney Cruise Line
3-Night Halloween on the High Seas Baja Cruise from San Diego
Aboard Disney Magic
San Diego, California → Ensenada → At Sea
3 nights · 4 departures
Balanced · 3 ports
AmericasHolland America Line
7-Day Mexican Riviera
Aboard Zaandam
San Diego, California → Cabo San Lucas → La Paz → Loreto
7 nights · 3 departures
Sea-paced · 4 ports
AmericasHolland America Line
16-Day Panama Canal
Aboard Eurodam
San Diego, California → Cabo San Lucas → Acapulco → Huatulco (Santa María Huatulco) +5 more
16 nights · 3 departures
Balanced · 9 ports
AmericasCrystal
Roundtrip San Diego
Aboard Crystal Serenity
San Diego, California → At Sea → Topolobampo → Loreto +2 more
9 nights · 2 departures
Balanced · 6 ports
PacificHolland America Line
4-Day Pacific Coastal Cruise
Aboard Nieuw Amsterdam
San Diego, California → Victoria, British Columbia → Vancouver, British Columbia
4 nights · 1 departure
Balanced · 3 ports
PacificHolland America Line
6-Day Pacific Coastal Cruise
Aboard Oosterdam
San Diego, California → Seattle, Washington → Victoria, British Columbia → Vancouver, British Columbia
6 nights · 1 departure
Balanced · 4 ports
AmericasHolland America Line
7-Day Baja Peninsula
Aboard Zuiderdam
San Diego, California → Cabo San Lucas → La Paz → Loreto
7 nights · 1 departure
Sea-paced · 4 ports
CaribbeanCrystal
San Diego to Vancouver
Aboard Crystal Symphony
San Diego, California → Santa Catalina Island, California → San Francisco, California → At Sea +4 more
8 nights · 1 departure
Port-rich · 8 ports
World CruiseMSC Cruises
San Diego, Cabo San Lucas, Puntarenas, BLB-Panam Canal, CTB-Panama Canal, Colon, Cartagena, Miami
Aboard MSC Poesia
San Diego, California → Cabo San Lucas → Puntarenas → Cruising Panama Canal +3 more
14 nights · 1 departure
Sea-paced · 7 ports
AmericasAzamara
Panama Canal & Latin America Cruise: Mexico, Costa Rica & Colombia
Aboard Azamara Quest
San Diego, California → Cabo San Lucas → Acapulco → Puerto Quetzal +5 more
17 nights · 1 departure
Balanced · 9 ports
PacificSilversea
San Diego to Papeete
Aboard Silver Whisper
San Diego, California → At Sea → Honolulu, Hawaii → Kailua-Kona, Hawaii +4 more
18 nights · 1 departure
Sea-paced · 8 ports
AmericasDisney Cruise Line
4-Night Baja Cruise from San Diego
Aboard Disney Wonder
San Diego, California → At Sea → Santa Catalina Island, California → Ensenada
4 nights · 6 departures
Port-rich · 4 ports
AmericasRoyal Caribbean International
4 Night Catalina & Ensenada Cruise
Aboard Serenade of the Seas
San Diego, California → Santa Catalina Island, California → Ensenada
4 nights · 6 departures
Balanced · 3 ports
AmericasNorwegian Cruise Line
Mexican Riviera: Cabo & Puerto Vallarta
Aboard Norwegian Star
San Diego, California → Puerto Vallarta → Cabo San Lucas
6 nights · 1 departure
Sea-paced · 3 ports
AmericasHolland America Line
7-Day Mexican Riviera
Aboard Koningsdam
San Diego, California → Cabo San Lucas → Mazatlán → Puerto Vallarta
7 nights · 4 departures
Sea-paced · 4 ports
AmericasDisney Cruise Line
4-Night Halloween on the High Seas Baja Cruise from San Diego
Aboard Disney Magic
San Diego, California → Santa Catalina Island, California → Ensenada → At Sea
4 nights · 3 departures
Port-rich · 4 ports
AmericasHolland America Line
12-Day Historical Baja Peninsula
Aboard Zaandam
San Diego, California → Cabo San Lucas → Loreto → Guaymas +5 more
12 nights · 2 departures
Balanced · 9 ports
PacificHolland America Line
6-Day Pacific Coastal Cruise
Aboard Eurodam
San Diego, California → San Francisco, California → Vancouver, British Columbia
6 nights · 2 departures
Sea-paced · 3 ports
AmericasCrystal
San Diego to Fuerte Amador
Aboard Crystal Serenity
San Diego, California → At Sea → Puerto Vallarta → Manzanillo, Mexico +5 more
11 nights · 1 departure
Port-rich · 9 ports
AmericasHolland America Line
16-Day Panama Canal
Aboard Nieuw Amsterdam
San Diego, California → Puerto Vallarta → Huatulco (Santa María Huatulco) → Puerto Chiapas +5 more
16 nights · 1 departure
Balanced · 9 ports
AmericasHolland America Line
7-Day Mexican Riviera
Aboard Zuiderdam
San Diego, California → La Paz → Mazatlán → Cabo San Lucas
7 nights · 1 departure
Sea-paced · 4 ports
AmericasCrystal
San Diego to Guayaquil
Aboard Crystal Symphony
San Diego, California → Ensenada → At Sea → Cabo San Lucas +6 more
12 nights · 1 departure
Port-rich · 10 ports
TranspacificAzamara
San Diego to London Grand Voyage
Aboard Azamara Quest
San Diego, California → Cabo San Lucas → Acapulco → Puerto Quetzal +15 more
35 nights · 1 departure
Balanced · 19 ports
World CruiseSilversea
World Cruise 2029
Aboard Silver Whisper
San Diego, California → At Sea → Honolulu, Hawaii → Kailua-Kona, Hawaii +58 more
126 nights · 1 departure
Balanced · 62 ports
AmericasDisney Cruise Line
5-Night Baja Cruise from San Diego
Aboard Disney Wonder
San Diego, California → Santa Catalina Island, California → Ensenada → At Sea
5 nights · 2 departures
Balanced · 4 ports
AmericasRoyal Caribbean International
7 Night Ensenada, Cabo & La Paz Cruise
Aboard Serenade of the Seas
San Diego, California → La Paz → Cabo San Lucas → Ensenada
7 nights · 6 departures
Sea-paced · 4 ports
RepositioningNorwegian Cruise Line
Panama Canal: Mexico & Colombia
Aboard Norwegian Star
San Diego, California → Cabo San Lucas → Acapulco → Puerto Quetzal +6 more
16 nights · 1 departure
Balanced · 10 ports
PacificHolland America Line
4-Day Pacific Coastal Cruise
Aboard Koningsdam
San Diego, California → Victoria, British Columbia → Vancouver, British Columbia
4 nights · 3 departures
Balanced · 3 ports
AmericasDisney Cruise Line
4-Night Pacific Coast Cruise from San Diego ending in Vancouver
Aboard Disney Magic
San Diego, California → At Sea → Vancouver, British Columbia
4 nights · 1 departure
Balanced · 3 ports
AmericasHolland America Line
15-Day Panama Canal Holiday
Aboard Zaandam
San Diego, California → Cabo San Lucas → Puerto Vallarta → Huatulco (Santa María Huatulco) +4 more
15 nights · 2 departures
Balanced · 8 ports
CaribbeanCrystal
San Diego to Callao (Lima)
Aboard Crystal Serenity
San Diego, California → At Sea → Cabo San Lucas → Mazatlán +8 more
15 nights · 1 departure
Port-rich · 12 ports
AmericasHolland America Line
14-Day Mexican Riviera & Baja Peninsula
Aboard Zuiderdam
San Diego, California → La Paz → Mazatlán → Cabo San Lucas +1 more
14 nights · 1 departure
Sea-paced · 5 ports
AmericasCrystal
San Diego to Vancouver
Aboard Crystal Symphony
San Diego, California → Santa Catalina Island, California → San Francisco, California → At Sea +11 more
18 nights · 1 departure
Port-rich · 15 ports
AmericasDisney Cruise Line
7-Night Very Merrytime Mexican Riviera Cruise from San Diego
Aboard Disney Wonder
San Diego, California → At Sea → Mazatlán → Cabo San Lucas +1 more
7 nights · 2 departures
Balanced · 5 ports
AmericasRoyal Caribbean International
7 Night Ensenada, Cabo & Mazatlan Cruise
Aboard Serenade of the Seas
San Diego, California → Ensenada → Cabo San Lucas → Mazatlán
7 nights · 2 departures
Sea-paced · 4 ports
AmericasHolland America Line
11-Day Mexican Riviera & Sea Of Cortez
Aboard Koningsdam
San Diego, California → Manzanillo, Mexico → Puerto Vallarta → Mazatlán +3 more
11 nights · 3 departures
Balanced · 7 ports
AmericasDisney Cruise Line
4-Night Baja Cruise from San Diego
Aboard Disney Magic
San Diego, California → At Sea → Ensenada
4 nights · 1 departure
Balanced · 3 ports
PacificHolland America Line
30-Day Circle Hawaii & Sea Of Cortez
Aboard Zaandam
San Diego, California → Hilo, Hawaii → Kailua-Kona, Hawaii → Kahului-Maui, Hawaii +10 more
30 nights · 2 departures
Sea-paced · 14 ports
CaribbeanCrystal
Roundtrip San Diego, California
Aboard Crystal Serenity
San Diego, California → At Sea → Topolobampo → Loreto +6 more
18 nights · 1 departure
Balanced · 10 ports
AmericasHolland America Line
15-Day Panama Canal
Aboard Zuiderdam
San Diego, California → Puerto Vallarta → Huatulco (Santa María Huatulco) → Puerto Chiapas +5 more
15 nights · 1 departure
Balanced · 9 ports
CaribbeanCrystal
San Diego to New York City
Aboard Crystal Symphony
San Diego, California → Ensenada → At Sea → Cabo San Lucas +21 more
32 nights · 1 departure
Port-rich · 25 ports
AmericasDisney Cruise Line
3-Night Halloween on the High Seas Baja Cruise from San Diego
Aboard Disney Wonder
San Diego, California → At Sea → Ensenada
3 nights · 1 departure
Balanced · 3 ports
Frequently asked
- How many cruises from San Diego, California does NestCruise have?
- 92 live sailings, 4 to 31 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines sail from San Diego, California?
- Holland America Line, Disney Cruise Line, Crystal and Royal Caribbean International, among others.
- How long are cruises from San Diego, California?
- Most run 4 to 31 nights.
- How much do cruises from San Diego, California cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.