Cruise itinerary
7-Night Americas Cruise from San Diego, California
7 nights · Americas · 4 ports of call
7-night Americas cruise aboard Serenade of the Seas, departing San Diego, California and calling at Ensenada, Cabo San Lucas and Mazatlán.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Royal Caribbean International
- Duration
- 7 nights
- Region
- Americas · Central America
- Departs
- San Diego, California
- Returns
- San Diego, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Serenade of the Seas sailing, typically within 24 hours.
Where this voyage takes you
- Family Friendly
Day-by-day itinerary
- Day1
San Diego, California
Depart 16:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2
Ensenada
Arrive 08:00 · Depart 16:00
A port city on the Pacific coast of Mexico's Baja California, the peninsula's first stop south of the US border. Its waterfront leads to a famed cantina and a market street, with the La Bufadora marine blowhole on the headland nearby.
- La Bufadora
- Hussong's Cantina
- Coastal wineries
- Day3At sea
- Day4
Cabo San Lucas
Arrive 08:00 · Depart 18:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day5
Mazatlán
Arrive 08:00 · Depart 16:00
A Pacific-coast resort city in Sinaloa, Mexico, strung along one of the longest seafront promenades in the country. The old town centres on the cathedral and Plaza Machado, while the Golden Zone draws beachgoers and the working harbour still lands shrimp.
- El Malecón
- Old Mazatlán
- Stone Island
- Day6At sea
- Day7At sea
- Day8
San Diego, California
Arrive 07:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
Upcoming departures
- 1 Nov 2026
- 8 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
7-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 7-night Americas cruise calls at San Diego, California, Ensenada, Cabo San Lucas and Mazatlán.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from San Diego, California.
How long is this cruise?
7 nights aboard Serenade of the Seas.
When does this itinerary sail?
Upcoming departures include 1 Nov 2026 and 8 Nov 2026. A NestCruise advisor can confirm current availability.