Cruise itinerary
21-Night South America Cruise from San Diego, California
21 nights · South America · 12 ports of call
21-night South America cruise aboard Nieuw Amsterdam, departing San Diego, California and calling at Cabo San Lucas, Huatulco (Santa María Huatulco), Puerto Quetzal, Puntarenas, Manta and Salaverry and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Nieuw Amsterdam
- Cruise line
- Holland America Line
- Duration
- 21 nights
- Region
- South America
- Departs
- San Diego, California
- Returns
- San Antonio
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Nieuw Amsterdam sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
Depart 17:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2At sea
- Day3
Cabo San Lucas
Arrive 11:00 · Depart 18:00
A resort town at the southern tip of Mexico's Baja California peninsula, where the desert meets the Pacific and Sea of Cortez. Cabo San Lucas is known for its rock arch at Land's End, sport fishing, and the marina lined with restaurants and boats.
- El Arco
- Lover's Beach
- Cabo marina
- Day4At sea
- Day5At sea
- Day6
Huatulco (Santa María Huatulco)
Arrive 07:00 · Depart 14:00
- Day7
Puerto Quetzal
Arrive 10:00 · Depart 20:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day8At sea
- Day9
Puntarenas
Arrive 08:00 · Depart 17:00
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day10At sea
- Day11
Manta
Arrive 12:00 · Depart 18:00
- Day12At sea
- Day13At sea
- Day14
Salaverry
Arrive 07:00 · Depart 16:00
- Day15
Callao
Arrive 10:00 · Depart 20:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day16At sea
- Day17
Pisco
Arrive 07:00 · Depart 18:00
- Day18At sea
- Day19
Arica
Arrive 08:00 · Depart 17:00
- Day20At sea
- Day21
Coquimbo
Arrive 08:00 · Depart 16:00
- Day22
San Antonio
Arrive 07:00
Upcoming departures
- 12 Oct 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night South America Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 21-night South America cruise calls at San Diego, California, Cabo San Lucas, Huatulco (Santa María Huatulco), Puerto Quetzal, Puntarenas, Manta, Salaverry, Callao, Pisco, Arica, Coquimbo and San Antonio.
How many days are spent at sea?
10 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in San Antonio.
How long is this cruise?
21 nights aboard Nieuw Amsterdam.
When does this itinerary sail?
Upcoming departures include 12 Oct 2027. A NestCruise advisor can confirm current availability.