Cruise itinerary
25-Night Americas Cruise from San Diego, California
25 nights · Americas · 18 ports of call
25-night Americas cruise aboard Crystal Serenity, departing San Diego, California and calling at At Sea, Puerto Vallarta, Manzanillo, Mexico, Zihuatanejo, Acajutla and San Juan del Sur and 11 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Crystal Serenity
- Cruise line
- Crystal
- Duration
- 25 nights
- Region
- Americas · North America
- Departs
- San Diego, California
- Returns
- New York, New York
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Crystal Serenity sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
San Diego, California
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day2
At Sea
- Day3
At Sea
- Day4
Puerto Vallarta
A resort city on Mexico's Pacific coast, set where the Sierra Madre meets Banderas Bay. Its cobbled Zona Romántica and the seaside Malecón promenade anchor an old town of churches and galleries, with whale-watching in the bay through the winter months.
- The Malecón
- Zona Romántica
- Banderas Bay
- Day5
Manzanillo, Mexico
- Day6
Zihuatanejo
- Day7
At Sea
- Day8
Acajutla
- Day9
San Juan del Sur
- Day10
Puntarenas
A Pacific port city on a narrow sandy spit on Costa Rica's central coast. It serves chiefly as a gateway inland to rainforests and volcanoes, with a long beachfront promenade and boats out to the Gulf of Nicoya's islands.
- Gulf of Nicoya
- Beachfront paseo
- Rainforest gateway
- Day11
At Sea
- Day12
Fuerte Amador
A causeway-linked island port on the Pacific side of the Panama Canal, just off Panama City. It serves as the gateway to the canal's locks and rainforest, with the Amador Causeway reaching toward the capital's skyline and old quarter.
- Panama Canal
- Amador Causeway
- Casco Viejo
- Day13
Panama Canal Transit
Fuerte Amador
A causeway-linked island port on the Pacific side of the Panama Canal, just off Panama City. It serves as the gateway to the canal's locks and rainforest, with the Amador Causeway reaching toward the capital's skyline and old quarter.
- Panama Canal
- Amador Causeway
- Casco Viejo
- Day14
Cartagena
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day15
Cartagena
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day16
At Sea
- Day17
Port Antonio
- Day18
Montego Bay
- Day19
Georgetown, Grand Cayman
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day20
At Sea
- Day21
Miami, Florida
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day22
Port Canaveral, Florida
A Florida port on the Space Coast and one of the busiest cruise gateways in the world. Ships sail from beside the Kennedy Space Center, with the beaches of Cocoa Beach and its landmark surf shop just down the coast.
- Kennedy Space Center
- Cocoa Beach
- Space Coast
- Day23
At Sea
- Day24
Norfolk, Virginia
- Day25
At Sea
- Day26
New York, New York
Cruise ships berth on Manhattan's West Side or across the harbour in Brooklyn and Bayonne, putting the full sweep of New York within reach. The Statue of Liberty, Central Park, Times Square and the museums of Fifth Avenue are all part of a day ashore.
- Statue of Liberty
- Central Park
- Times Square
Upcoming departures
- 9 Aug 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
25-Night Americas Cruise from San Diego, California FAQ
Which ports does this cruise visit?
This 25-night Americas cruise calls at San Diego, California, At Sea, Puerto Vallarta, Manzanillo, Mexico, Zihuatanejo, Acajutla, San Juan del Sur, Puntarenas, Fuerte Amador, Panama Canal Transit, Cartagena, Port Antonio, Montego Bay, Georgetown, Grand Cayman, Miami, Florida, Port Canaveral, Florida, Norfolk, Virginia and New York, New York.
How many days are spent at sea?
8 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from San Diego, California and ends in New York, New York.
How long is this cruise?
25 nights aboard Crystal Serenity.
When does this itinerary sail?
Upcoming departures include 9 Aug 2027. A NestCruise advisor can confirm current availability.