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Cruises to Siracuse

97 live cruises call at Siracuse — 7 to 27 nights, departing 20 ports, across 7 lines. A NestCruise advisor narrows them to the one that fits.

97 sailings
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Legendary shores of Italy and CroatiaEurope

PONANT EXPLORATIONS

8 nights: Civitavecchia & Venice, the Mediterranean

Aboard Le Boréal

Civitavecchia → Venice

Rare itinerary
Sails weekly, May 2027
A Circumnavigation of Sicily – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

8 nights: Valletta, the Mediterranean

Aboard Le Dumont-d'Urville

Round-trip from Valletta

Rare itinerary
Aug 2026 – May 2027Next 29 Aug 2026 · 1 more
Italy Intensive Cruise: Amalfi, Siracusa & VeniceEurope

Azamara

10 nights: Civitavecchia & Venice, the Mediterranean

Aboard Azamara Journey

Civitavecchia → Venice

Overnight in VeniceRare itinerary
Apr 2028 – Sep 2028Next 15 Apr 2028 · 1 more
Mediterranean crossroadsEurope

Emerald Cruises

10 nights: Valletta & Mykonos, the Mediterranean

Aboard Emerald Azzurra

Valletta → Piraeus

Rare itinerary
May 2027 – Oct 2028Next 19 May 2027 · 1 more
Civitavecchia to FusinaEurope

Silversea

10 nights: Civitavecchia & Dubrovnik, the Mediterranean

Aboard Silver Muse

Civitavecchia → Fusina

Rare itinerary
Sep 2026Next 14 Sep 2026
Egypt, Malta & Italy Cruise: Alexandria, Valletta & AmalfiEurope

Azamara

14 nights: Valletta & Civitavecchia, the Mediterranean

Aboard Azamara Onward

Piraeus → Civitavecchia

Overnight in AlexandriaRare itinerary
Oct 2026 – Oct 2028Next 17 Oct 2026 · 1 more
Barcelona → La VallettaMediterranean & Western Europe

Explora Journeys

6 nights: Barcelona & Mykonos

Aboard EXPLORA II

Barcelona → Piraeus

Rare itinerary
Mar 2027Next 14 Mar 2027
Lisbon to BarcelonaEurope

Crystal

7 nights: Barcelona & Dubrovnik, Western Europe

Aboard Crystal Serenity

Lisbon → Piraeus

Overnight in RavennaRare itinerary
Aug 2026Next 14 Aug 2026
Lisbon → BarcelonaMediterranean & Western Europe

Explora Journeys

7 nights: Barcelona & Kotor

Aboard EXPLORA IV

Lisbon → Fusina

Overnight in LisbonRare itinerary
Oct 2028Next 14 Oct 2028
Fusina (Venice) → Civitavecchia (Rome)Mediterranean & Western Europe

Explora Journeys

7 nights: Kotor & Civitavecchia

Aboard EXPLORA V

Fusina → Civitavecchia

Rare itinerary
Apr 2028Next 8 Apr 2028
Authentic Mediterranean ShoresEurope

PONANT EXPLORATIONS

7 nights: Valletta, the Mediterranean

Aboard Le Bougainville

Round-trip from Valletta

Rare itinerary
Apr 2027Next 8 Apr 2027
Greece, Italy & Spain Cruise: Athens, Siracusa & MalagaEurope

Azamara

8 nights: Piraeus & Valletta, the Mediterranean

Aboard Azamara Quest

Piraeus → Málaga

Rare itinerary
Nov 2026Next 26 Nov 2026
Civitavecchia (Rome) to Piraeus (Athens)Europe

Crystal

8 nights: Civitavecchia & Dubrovnik, the Mediterranean

Aboard Crystal Symphony

Round-trip from Civitavecchia

Overnight in RavennaRare itinerary
Apr 2027Next 26 Apr 2027
Ancient Cities of the MediterraneanEurope

PONANT EXPLORATIONS

8 nights: Athens & Valletta, the Mediterranean

Aboard Le Champlain

Athens → Valletta

Rare itinerary
Nov 2026Next 8 Nov 2026
Ancient Wonders and Culinary Delights: Cruising Southern Italy and Sicily – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

8 nights: Civitavecchia & Naples, the Mediterranean

Aboard Le Lapérouse

Civitavecchia → Valletta

Rare itinerary
Oct 2027Next 7 Oct 2027
Greek & Italian IslesEurope

Oceania Cruises

9 nights: Civitavecchia & Valletta, the Mediterranean

Aboard Oceania Allura

Civitavecchia → Piraeus

Rare itinerary
Oct 2027Next 6 Oct 2027
Yachting Sicily to Elba via the Amalfi CoastEurope

Emerald Cruises

10 nights: Valletta & Civitavecchia, the Mediterranean

Aboard Emerald Sakara

Valletta → Civitavecchia

Rare itinerary
Jun 2027Next 30 Jun 2027
Visions Of ByzantiumEurope

Oceania Cruises

10 nights: Barcelona & Istanbul, the Mediterranean

Aboard Oceania Sirena

Barcelona → Istanbul

Rare itinerary
Aug 2026Next 17 Aug 2026
Tales Of The AncientsEurope

Oceania Cruises

11 nights: Istanbul & Santorini, the Mediterranean

Aboard Oceania Nautica

Istanbul → Civitavecchia

Rare itinerary
Jun 2027Next 16 Jun 2027
Sicilian interludeEurope

PONANT EXPLORATIONS

5 nights: Valletta, the Mediterranean

Aboard Le Boréal

Palermo → Valletta

Rare itinerary
Jun 2027Next 1 Jun 2027
Ancient shores of the MediterraneanEurope

PONANT EXPLORATIONS

9 nights: Valletta, the Mediterranean

Aboard Le Dumont-d'Urville

Valletta → Málaga

Rare itinerary
Oct 2026 – Nov 2027Next 29 Oct 2026 · 1 more
Greece & Italy Cruise: Olympia, Catania & Amalfi Coast (Salerno)Europe

Azamara

7 nights: Piraeus & Civitavecchia, the Mediterranean

Aboard Azamara Journey

Piraeus → Civitavecchia

Overnight in SalernoRare itinerary
Feb 2028Next 26 Feb 2028
Enchanting Greece & the Amalfi CoastEurope

Emerald Cruises

10 nights: Mykonos & Civitavecchia, the Mediterranean

Aboard Emerald Azzurra

Piraeus → Civitavecchia

Overnight in SorrentoRare itinerary
Oct 2026Next 17 Oct 2026
Italy Intensive Cruise: Siracusa, Amalfi Coast & RomeEurope

Azamara

7 nights: Valletta & Civitavecchia, the Mediterranean

Aboard Azamara Onward

Piraeus → Civitavecchia

Overnight in SalernoRare itinerary
Nov 2027Next 25 Nov 2027
Civitavecchia (Rome) → BarcelonaMediterranean & Western Europe

Explora Journeys

9 nights: Barcelona & Mykonos

Aboard EXPLORA II

Civitavecchia → Piraeus

Overnight in MálagaRare itinerary
Mar 2027Next 5 Mar 2027
Civitavecchia (Rome) to Piraeus (Athens)Europe

Crystal

8 nights: Civitavecchia & Valletta, the Mediterranean

Aboard Crystal Serenity

Civitavecchia → Piraeus

Rare itinerary
May 2028Next 13 May 2028
Barcelona → Fusina (Venice)Mediterranean & Western Europe

Explora Journeys

10 nights: Barcelona & Dubrovnik

Aboard EXPLORA IV

Barcelona → Jeddah

Rare itinerary
Oct 2028Next 21 Oct 2028
Istanbul → Civitavecchia (Rome)Mediterranean & Western Europe

Explora Journeys

7 nights: Istanbul & Naples

Aboard EXPLORA V

Istanbul → Civitavecchia

Rare itinerary
Dec 2027Next 12 Dec 2027
6th Opera Festival at Sea, with Benjamin BernheimEurope

PONANT EXPLORATIONS

8 nights: Dubrovnik & Venice, the Mediterranean

Aboard Le Bougainville

Valletta → Venice

Overnight in VeniceRare itinerary
May 2027Next 13 May 2027
Transatlantic Combination Cruise: Malta, Malaga & MiamiTransatlantic

Azamara

21 nights: Valletta & San Juan, the Atlantic crossing

Aboard Azamara Quest

Piraeus → Miami

Rare itinerary
Nov 2026Next 26 Nov 2026
Dubai to JeddahEurope

Crystal

9 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Crystal Symphony

Dubai → Fort Lauderdale

Overnight in DubaiRare itinerary
Apr 2028Next 26 Apr 2028
Ancient shores of the MediterraneanEurope

PONANT EXPLORATIONS

9 nights: Valletta, the Mediterranean

Aboard Le Champlain

Valletta → Málaga

Rare itinerary
Nov 2026Next 16 Nov 2026
A Circumnavigation of Sicily – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

8 nights: Valletta, the Mediterranean

Aboard Le Lapérouse

Round-trip from Valletta

Rare itinerary
Oct 2027Next 15 Oct 2027
Marvels Of The MediterraneanEurope

Oceania Cruises

19 nights: Barcelona & Civitavecchia, the Mediterranean

Aboard Oceania Allura

Lisbon → Piraeus

Rare itinerary
Sep 2027Next 26 Sep 2027
Discover Coastal Shores and Hidden GemsEurope

Emerald Cruises

17 nights: Valletta & Civitavecchia, the Mediterranean

Aboard Emerald Sakara

Valletta → Nice

Rare itinerary
Jun 2027Next 30 Jun 2027
European ExplorerEurope

Oceania Cruises

22 nights: Barcelona & Istanbul, the Mediterranean

Aboard Oceania Sirena

Southampton → Istanbul

Rare itinerary
Aug 2026Next 5 Aug 2026
Authentic Mediterranean ShoresEurope

PONANT EXPLORATIONS

8 nights: Valletta, the Mediterranean

Aboard Le Boréal

Round-trip from Valletta

Rare itinerary
Jun 2027Next 6 Jun 2027
The Mediterranean: in the Footsteps of Great CivilisationsEurope

PONANT EXPLORATIONS

10 nights: Valletta & Corfu, the Mediterranean

Aboard Le Dumont-d'Urville

Valletta → Antalya

Rare itinerary
Apr 2027Next 13 Apr 2027 · 1 more
Best of the Mediterranean Cruise: La Goulette, Valletta & SiracusaEurope

Azamara

9 nights: Valletta & Piraeus, the Mediterranean

Aboard Azamara Journey

Málaga → Piraeus

Overnight in PiraeusRare itinerary
Jan 2028Next 29 Jan 2028
Discover the Charm of the Greek Isles & the Amalfi CoastEurope

Emerald Cruises

17 nights: Mykonos & Santorini, the Mediterranean

Aboard Emerald Azzurra

Piraeus → Civitavecchia

Overnight in SorrentoRare itinerary
Oct 2026Next 10 Oct 2026
Italy & Greece Cruise: Amalfi Coast, Siracusa & OlympiaEurope

Azamara

7 nights: Civitavecchia & Piraeus, the Mediterranean

Aboard Azamara Onward

Civitavecchia → Piraeus

Overnight in SalernoRare itinerary
Dec 2026Next 5 Dec 2026
Barcelona → Civitavecchia (Rome)Mediterranean & Western Europe

Explora Journeys

17 nights: Barcelona & Civitavecchia

Aboard EXPLORA II

Barcelona → Civitavecchia

Overnight in FécampRare itinerary
Dec 2026Next 28 Dec 2026
Lisbon to Civitavecchia (Rome)Europe

Crystal

8 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Crystal Serenity

Lisbon → Barcelona

Overnight in Monte-CarloRare itinerary
May 2028Next 5 May 2028
Ancient shores of the MediterraneanEurope

PONANT EXPLORATIONS

9 nights: Valletta, the Mediterranean

Aboard Le Bougainville

Valletta → Málaga

Rare itinerary
Oct 2027Next 30 Oct 2027
Jeddah to VallettaEurope

Crystal

13 nights: Valletta, the Mediterranean

Aboard Crystal Symphony

Jeddah → Valletta

Overnight in JeddahRare itinerary
May 2028Next 5 May 2028
Tribute to Maria CallasEurope

PONANT EXPLORATIONS

8 nights: Athens & Civitavecchia, the Mediterranean

Aboard Le Lapérouse

Athens → Civitavecchia

Rare itinerary
Sep 2027Next 29 Sep 2027
Authentic Mediterranean shoresEurope

PONANT EXPLORATIONS

9 nights: Valletta, the Mediterranean

Aboard Le Boréal

Round-trip from Valletta

Rare itinerary
Oct 2026Next 1 Oct 2026
Mediterranean Island Voyage: Sicily, Sardinia, Corsica, and Elba – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

7 nights: Nice & Valletta, the Mediterranean

Aboard Le Dumont-d'Urville

Nice → Valletta

Rare itinerary
Jun 2027Next 7 Jun 2027

Frequently asked

How many cruises to Siracuse does NestCruise have?
97 live sailings, 7 to 27 nights. A NestCruise advisor narrows them to the one that fits.
Which cruise lines visit Siracuse?
Azamara, PONANT EXPLORATIONS, Crystal and Explora Journeys, among others.
How long are cruises to Siracuse?
Most run 7 to 27 nights.
How much do cruises to Siracuse cost?
NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.