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Cruises to Palermo

160 live cruises call at Palermo — 7 to 23 nights, departing 29 ports, across 18 lines. A NestCruise advisor narrows them to the one that fits.

160 sailings
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Spain, France, ItalyEurope

MSC Cruises

7 nights: Barcelona & Civitavecchia, the Mediterranean

Aboard MSC Seaview

Round-trip from Barcelona

Open Jaw Cruise

from$366pp · cruise fare≈ $52/night pp

Fares checked nightly

Sails every two weeks, Sep 2026 – Aug 2027
Barcelona, Marseille, Genoa, Naples, Palermo, La Goulette, BarcelonaEurope

MSC Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard MSC Euribia

Round-trip from Barcelona

Cruise Only Obc

from$460pp · cruise fare≈ $66/night pp

Fares checked nightly

Sails every two weeks, Oct 2026 – Jan 2028
Barcelona, La Goulette, Palermo, Naples, Livorno, Marseille, BarcelonaEurope

MSC Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard MSC Virtuosa

Round-trip from Barcelona

Balcony at Oceanview

from$705pp · cruise fare≈ $101/night pp

Fares checked nightly

Sails weekly, Apr 2027 – Nov 2027
Palermo, Ibiza, Valencia, Marseille, Genoa, Civitavecchia, PalermoEurope

MSC Cruises

7 nights: Ibiza & Civitavecchia, the Mediterranean

Aboard MSC Musica

Round-trip from Palermo

Cruise Only Obc

from$700pp · cruise fare≈ $100/night pp

Fares checked nightly

Sails weekly, Apr 2027 – Oct 2027
Spain, Tunisia, Italy, FranceEurope

MSC Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard MSC Meraviglia

Round-trip from Barcelona

Open Jaw Cruise

from$549pp · cruise fare≈ $78/night pp

Fares checked nightly

Sails weekly, Sep 2026 – Oct 2026
Greco-Roman WorldEurope

Oceania Cruises

7 nights: Valletta & Civitavecchia, the Mediterranean

Aboard Oceania Allura

Piraeus → Civitavecchia

May 2027 – Oct 2027Next 7 May 2027 · 3 more
Greek Isles & Italy CruiseEurope

Royal Caribbean International

7 nights: Barcelona & Mykonos, the Mediterranean

Aboard Explorer of the Seas

Barcelona → Piraeus

from$800pp · cruise fare≈ $114/night pp

Fares checked nightly

May 2027 – Sep 2027Next 31 May 2027 · 3 more
9-Night Mediterranean CruiseMediterranean

Oceania Cruises

9 nights: Barcelona & Venice, the Mediterranean

Aboard Oceania Sirena

Barcelona → Venice

Rare itinerary
Apr 2027 – Mar 2028Next 26 Apr 2027 · 2 more
Mediterranean with Greek IslesMediterranean

Princess Cruises

10 nights: Istanbul & Naples, the Mediterranean

Aboard Enchanted Princess

Piraeus-Athens → Civitavecchia-Rome

Overnight in IstanbulRare itinerary
May 2027 – Oct 2027Next 22 May 2027 · 2 more
A Circumnavigation of Sicily – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

8 nights: Valletta, the Mediterranean

Aboard Le Dumont-d'Urville

Round-trip from Valletta

Rare itinerary
May 2027Next 10 May 2027
10-Day Europe from Barcelona: Spain, Gibraltar, France & ItalyNorthern Europe

Norwegian Cruise Line

10 nights: Civitavecchia & Barcelona, Northern Europe

Aboard Norwegian Dawn

Civitavecchia → Barcelona

↓ $1,289 this month50% Off All

from$1,489pp · cruise fare≈ $149/night pp

Fares checked nightly

Apr 2027 – Oct 2027Next 29 Apr 2027 · 1 more
Fusina to CivitavecchiaEurope

Silversea

10 nights: Kotor & Naples, the Mediterranean

Aboard Silver Nova

Fusina → Civitavecchia

↓ $2,500 this monthRare itinerary

from$5,400pp · cruise fare≈ $540/night pp

Fares checked nightly

Nov 2026 – Oct 2027Next 13 Nov 2026 · 1 more
Piraeus (Athens) to BarcelonaEurope

Crystal

11 nights: Valletta & Barcelona, the Mediterranean

Aboard Crystal Grace

Piraeus → Barcelona

Overnight in ValenciaRare itinerary

from$10,300pp · cruise fare≈ $936/night pp

Fares checked nightly

Sails monthly, Jun 2028 – Jul 2028
14-Night Mediterranean CruiseMediterranean

Cunard

14 nights: Dubrovnik & Barcelona, the Mediterranean

Aboard Queen Elizabeth

Civitavecchia-Rome → Barcelona

Rare itinerary

from$4,139pp · cruise fare≈ $296/night pp

Fares checked nightly

May 2027 – Oct 2027Next 28 May 2027 · 1 more
28-Day Greek Isles & Solar EclipseEurope

Holland America Line

28 nights: Barcelona & Santorini, the Mediterranean

Aboard Oosterdam

Barcelona → Piraeus

Overnight in AlexandriaRare itinerary

from$9,309pp · cruise fare≈ $332/night pp

Fares checked nightly

Sails weekly, Jul 2027
La Valletta → Civitavecchia (Rome)Mediterranean & Western Europe

Explora Journeys

4 nights: Valletta & Civitavecchia

Aboard EXPLORA II

Valletta → Civitavecchia

↓ $915 this monthWinter 2026-2027

from$2,135pp · cruise fare≈ $534/night pp

Fares checked nightly

Jan 2027Next 10 Jan 2027
Sicilian interludeEurope

PONANT EXPLORATIONS

5 nights: Valletta, the Mediterranean

Aboard Le Boréal

Palermo → Valletta

Rare itinerary
Jun 2027Next 1 Jun 2027
7-Night Mediterranean CruiseMediterranean

Carnival Cruise Line

7 nights: Barcelona & Naples, the Mediterranean

Aboard Carnival Sunshine

Round-trip from Barcelona

Rare itinerary

from$791pp · cruise fare≈ $113/night pp

Fares checked nightly

Oct 2027Next 9 Oct 2027
Piraeus (Athens) to BarcelonaTransatlantic

Crystal

7 nights: Valletta & Barcelona, the Atlantic crossing

Aboard Crystal Serenity

Piraeus → Fort Lauderdale

Rare itinerary

from$4,300pp · cruise fare≈ $614/night pp

Fares checked nightly

Nov 2028Next 4 Nov 2028
Mediterranean HolidayEurope

Oceania Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard Oceania Insignia

Barcelona → Civitavecchia

Rare itinerary
Oct 2026Next 6 Oct 2026
7-Night Mediterranean CruiseMediterranean

PONANT EXPLORATIONS

7 nights: Barcelona & Valletta, the Mediterranean

Aboard Le Bougainville

Barcelona → Valletta

Rare itinerary
Aug 2027Next 12 Aug 2027
Under Sail from the Riviera to SicilyEurope

PONANT EXPLORATIONS

7 nights: Nice, the Mediterranean

Aboard Le Ponant

Nice → Palermo

Rare itinerary
Jun 2027Next 1 Jun 2027
Italy, France & Croatia CruiseEurope

Royal Caribbean International

7 nights: Barcelona & Civitavecchia, the Mediterranean

Aboard Mariner of the Seas

Barcelona → Ravenna

Rare itinerary

from$1,077pp · cruise fare≈ $154/night pp

Fares checked nightly

Jul 2027Next 2 Jul 2027
Sicilian RhapsodyEurope

Regent Seven Seas Cruises

7 nights: Civitavecchia, the Mediterranean

Aboard Seven Seas Grandeur

Civitavecchia → Fusina

↓ $11,799 this monthBonus Savings of

from$6,799pp · cruise fare≈ $971/night pp

Fares checked nightly

Jul 2028Next 5 Jul 2028
A Circumnavigation of Sicily – with Smithsonian JourneysEurope

PONANT EXPLORATIONS

8 nights: Valletta, the Mediterranean

Aboard Le Lapérouse

Round-trip from Valletta

Rare itinerary
Oct 2027Next 15 Oct 2027
8-Night Greece, Italy, Montenegro, Croatia & SloveniaMEDITERRANEAN

Seabourn

8 nights: Kotor & Venice, the Mediterranean

Aboard Seabourn Ovation

Piraeus → Civitavecchia

Rare itinerary

from$10,298pp · cruise fare≈ $1,287/night pp

Fares checked nightly

Jun 2027Next 5 Jun 2027
9-Night Mediterranean CruiseMediterranean

Norwegian Cruise Line

9 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Norwegian Prima

Civitavecchia → Barcelona

Rare itinerary
Apr 2027Next 28 Apr 2027
Art Of The MediterraneanEurope

Regent Seven Seas Cruises

9 nights: Civitavecchia & Kotor, the Mediterranean

Aboard Seven Seas Explorer

Civitavecchia → Fusina

Rare itinerary
Sep 2028Next 5 Sep 2028
Italy Intensive Cruise: Venice, Sicily & AmalfiEurope

Azamara

10 nights: Kotor & Civitavecchia, the Mediterranean

Aboard Azamara Journey

Fusina → Civitavecchia

Rare itinerary

from$3,979pp · cruise fare≈ $398/night pp

Fares checked nightly

May 2027Next 5 May 2027
Italy, Spain & MaltaEurope

Celebrity Cruises

10 nights: Barcelona & Civitavecchia, the Mediterranean

Aboard Celebrity Equinox

Round-trip from Barcelona

Rare itinerary

from$2,295pp · cruise fare≈ $229/night pp

Fares checked nightly

Oct 2026Next 20 Oct 2026
10-Night Mediterranean CruiseMediterranean

Emerald Cruises

10 nights: Rome & Civitavecchia, the Mediterranean

Aboard Emerald Sakara

Rome → Valletta

↓ $1,380 this monthIncludes Preferred Savings

from$13,675pp · cruise fare≈ $1,368/night pp

Fares checked nightly

Jun 2027Next 19 Jun 2027
Civitavecchia (Rome) → BarcelonaMediterranean & Western Europe

Explora Journeys

10 nights: Civitavecchia & Barcelona

Aboard EXPLORA VI

Round-trip from Civitavecchia

↓ $3,320 this monthSummer 2028

from$6,580pp · cruise fare≈ $658/night pp

Fares checked nightly

Aug 2028Next 4 Aug 2028
The Birth Of CivilizationEurope

Oceania Cruises

10 nights: Mykonos & Istanbul, the Mediterranean

Aboard Oceania Marina

Piraeus → Civitavecchia

Overnight in IstanbulRare itinerary
Nov 2027Next 17 Nov 2027
Renaissance & RivierasEurope

Oceania Cruises

10 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Oceania Nautica

Civitavecchia → Barcelona

Overnight in LivornoRare itinerary
Jun 2027Next 27 Jun 2027
Italy, Spain & French RivieraEurope

Virgin Voyages

10 nights: Barcelona & Rome, Western Europe

Aboard Resilient Lady

Round-trip from Barcelona

↓ $1,980 this monthRare itinerary

from$4,180pp · cruise fare≈ $418/night pp

Fares checked nightly

Sep 2027Next 2 Sep 2027
Old World ExplorationEurope

Regent Seven Seas Cruises

10 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Seven Seas Navigator

Civitavecchia → Barcelona

↓ $13,349 this monthBonus Savings of

from$7,349pp · cruise fare≈ $735/night pp

Fares checked nightly

Nov 2026Next 1 Nov 2026
Breathtaking Greek IslesEurope

Regent Seven Seas Cruises

10 nights: Mykonos & Santorini, the Mediterranean

Aboard Seven Seas Prestige

Ravenna → Barcelona

Rare itinerary
Jul 2027Next 5 Jul 2027
Luminous ItalyEurope

Regent Seven Seas Cruises

10 nights: Barcelona & Monaco, the Mediterranean

Aboard Seven Seas Voyager

Barcelona → Civitavecchia

↓ $12,899 this monthBonus Savings of

from$6,899pp · cruise fare≈ $690/night pp

Fares checked nightly

Apr 2028Next 1 Apr 2028
Italy & Spain Solar EclipseEurope

Celebrity Cruises

11 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Celebrity Ascent

Round-trip from Civitavecchia

Rare itinerary

from$3,411pp · cruise fare≈ $310/night pp

Fares checked nightly

Jul 2027Next 26 Jul 2027
Mediterranean: Rome to AthensEurope

Virgin Voyages

12 nights: Rome & Mykonos, the Mediterranean

Aboard Scarlet Lady

Rome → Piraeus

↓ $2,174 this monthRare itinerary

from$4,776pp · cruise fare≈ $398/night pp

Fares checked nightly

Sep 2027Next 7 Sep 2027
Civitavecchia (Rome) → BarcelonaMediterranean & Western Europe

Explora Journeys

16 nights: Civitavecchia & Barcelona

Aboard EXPLORA I

Civitavecchia → Barcelona

↓ $2,295 this monthSummer 2026

from$13,455pp · cruise fare≈ $841/night pp

Fares checked nightly

Oct 2026Next 5 Oct 2026
Palermo, Valletta, Barcelona, Gibraltar, Casablanca, Las Palmas de G.Canaria, Maceio, Salvador, Rio de Janeiro, MontevideoWorld Cruise

MSC Cruises

20 nights: Barcelona & Rio de Janeiro

Aboard MSC Splendida

Palermo → Montevideo

Cruise Only ObcRare itinerary

from$4,117pp · cruise fare≈ $206/night pp

Fares checked nightly

Nov 2026Next 12 Nov 2026
France, Italy, SpainEurope

MSC Cruises

7 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard MSC Seaview

Round-trip from Marseille

Open Jaw Cruise

from$366pp · cruise fare≈ $52/night pp

Fares checked nightly

Sails every two weeks, Sep 2026 – Jul 2027
Marseille, Genoa, Naples, Palermo, La Goulette, Barcelona, MarseilleEurope

MSC Cruises

7 nights: Naples & Barcelona, the Mediterranean

Aboard MSC Euribia

Round-trip from Marseille

Cruise Only Obc

from$460pp · cruise fare≈ $66/night pp

Fares checked nightly

Sails every two weeks, Oct 2026 – Jan 2028
Marseille, Barcelona, La Goulette, Palermo, Naples, Livorno, MarseilleEurope

MSC Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard MSC Virtuosa

Round-trip from Marseille

Balcony at Oceanview

from$705pp · cruise fare≈ $101/night pp

Fares checked nightly

Sails weekly, Apr 2027 – Nov 2027
Genoa, Civitavecchia, Palermo, Ibiza, Valencia, Marseille, GenoaEurope

MSC Cruises

7 nights: Civitavecchia & Ibiza, the Mediterranean

Aboard MSC Musica

Round-trip from Genoa

Cruise Only Obc

from$696pp · cruise fare≈ $99/night pp

Fares checked nightly

Sails weekly, Apr 2027 – May 2027
Marseille, Barcelona, La Goulette, Palermo, Naples, Livorno, MarseilleEurope

MSC Cruises

7 nights: Barcelona & Naples, the Mediterranean

Aboard MSC Meraviglia

Round-trip from Marseille

Open Jaw Cruise

from$549pp · cruise fare≈ $78/night pp

Fares checked nightly

Sails weekly, Sep 2026 – Oct 2026
9-Night Mediterranean CruiseMediterranean

Oceania Cruises

9 nights: Civitavecchia & Barcelona, the Mediterranean

Aboard Oceania Allura

Civitavecchia → Barcelona

Sep 2027 – Apr 2028Next 3 Sep 2027 · 3 more

Frequently asked

How many cruises to Palermo does NestCruise have?
160 live sailings, 7 to 23 nights. A NestCruise advisor narrows them to the one that fits.
Which cruise lines visit Palermo?
MSC Cruises, Oceania Cruises, PONANT EXPLORATIONS and Regent Seven Seas Cruises, among others.
How long are cruises to Palermo?
Most run 7 to 23 nights.
How much do cruises to Palermo cost?
NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.