Cruises to Mytilene
12 live cruises call at Mytilene — 7 to 22 nights, departing 4 ports, across 2 lines. A NestCruise advisor narrows them to the one that fits.
EuropeExplora Journeys
A Journey from Golden Greek Islands to Turkish Treasures
Aboard EXPLORA I
Piraeus → Skíathos → Thessaloníki → Istanbul +2 more
7 nights · 3 departures
Port-rich · 6 ports
EuropeExplora Journeys
A Journey of Greek Treasures & Soulful Shores
Aboard EXPLORA II
Piraeus → Skíathos → Kusadasi → Mytilene, Lesbos +2 more
7 nights · 3 departures
Port-rich · 6 ports
EuropeRegent Seven Seas Cruises
Aegean Wonders
Aboard Seven Seas Voyager
Piraeus → Adriatic Sea → Split → Cruising the Ionian Sea +6 more
10 nights · 1 departure
Port-rich · 10 ports
EuropeRegent Seven Seas Cruises
Acropolis To Amalfi
Aboard Seven Seas Mariner
Piraeus → Mykonos → Bozcaada → Istanbul +10 more
14 nights · 1 departure
Port-rich · 14 ports
EuropeExplora Journeys
An Extended Journey through Ancient Marvels, Thriving Markets & Byzantine Grandeur
Aboard EXPLORA I
Piraeus → Skíathos → Thessaloníki → Istanbul +8 more
14 nights · 3 departures
Port-rich · 12 ports
EuropeRegent Seven Seas Cruises
Knights & Emperors
Aboard Seven Seas Voyager
Istanbul → Mytilene, Lesbos → Kusadasi → Heraklion (Iraklion), Crete +8 more
12 nights · 1 departure
Port-rich · 12 ports
EuropeRegent Seven Seas Cruises
Ruins, Riviera & Rose Sands
Aboard Seven Seas Mariner
Piraeus → Mykonos → Bozcaada → Istanbul +15 more
28 nights · 1 departure
Balanced · 19 ports
EuropeExplora Journeys
An Extended Journey through Greek Splendour, Byzantine History & Timeless Piazzas
Aboard EXPLORA I
Fusina → Koper → Hvar Island → Dubrovnik +9 more
14 nights · 3 departures
Port-rich · 13 ports
EuropeRegent Seven Seas Cruises
Ancient & Historic Shores
Aboard Seven Seas Voyager
Trieste → Split → Dubrovnik → Kotor +10 more
17 nights · 1 departure
Port-rich · 14 ports
EuropeExplora Journeys
A Journey of Classical Greek Spectacles & the Vibrant Charms of Istanbul
Aboard EXPLORA I
Piraeus → Vólos → Thessaloníki → Istanbul +2 more
7 nights · 1 departure
Port-rich · 6 ports
Frequently asked
- How many cruises to Mytilene does NestCruise have?
- 12 live sailings, 7 to 22 nights. A NestCruise advisor narrows them to the one that fits.
- Which cruise lines visit Mytilene?
- Explora Journeys and Regent Seven Seas Cruises, among others.
- How long are cruises to Mytilene?
- Most run 7 to 22 nights.
- How much do cruises to Mytilene cost?
- NestCruise doesn't publish fares — it's a quote-only concierge. Share your dates and party size and an advisor prices your exact sailing at no cost.