Cruise itinerary
12-Night Europe Cruise from Istanbul
12 nights · Europe · 12 ports of call
12-night Europe cruise aboard Seven Seas Voyager, departing Istanbul and calling at Mytilene, Lesbos, Kusadasi, Heraklion (Iraklion), Crete, Cruising the Ionian Sea, Dubrovnik and Kotor and 5 more.
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At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 12 nights
- Region
- Europe · Southern Europe · Mediterranean
- Departs
- Istanbul
- Returns
- Civitavecchia
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Voyager sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Istanbul
Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day2
Mytilene, Lesbos
Arrive 09:00 · Depart 18:00
- Day3
Kusadasi
Arrive 08:00 · Depart 17:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day4
Heraklion (Iraklion), Crete
Arrive 08:00 · Depart 17:00
The largest city on Crete and the island's main port, in Greece. A Venetian harbour and fortress front the town, while the Bronze Age palace of Knossos and the Heraklion Archaeological Museum's Minoan treasures lie close by.
- Palace of Knossos
- Venetian harbour
- Archaeological Museum
- Day5
Cruising the Ionian Sea
- Day6
Dubrovnik
Arrive 08:00 · Depart 18:00
A walled city on Croatia's Dalmatian coast, its limestone old town wrapped in sea-facing ramparts above the Adriatic. Ships call here for the marble main street of Stradun, the circuit of the city walls and the cable car to Mount Srđ.
- City walls
- Stradun
- Mount Srđ cable car
- Day7
Kotor
Arrive 08:00 · Depart 16:00
A walled medieval town at the head of the Bay of Kotor, a fjord-like inlet of the Adriatic ringed by steep mountains. Ships anchor below the old town, whose stone lanes and ramparts climb toward the fortress of San Giovanni.
- Bay of Kotor
- Old town walls
- San Giovanni fortress
- Day8
Corfu
Arrive 09:00 · Depart 18:00
An Ionian island off Greece's northwest coast, greener and more Venetian-feeling than the Aegean isles. Ships call at its old town, a UNESCO-listed warren of Italianate streets between two hilltop fortresses, with pebbly coves around the shore.
- Old Fortress
- Liston arcade
- Ionian coves
- Day9
Cruising the Ionian Sea
- Day10
Valletta
Arrive 07:00 · Depart 17:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day11
Catania
Arrive 07:00 · Depart 16:00
A port city on the east coast of Sicily, built in dark volcanic stone beneath Mount Etna, Europe's most active volcano. Its baroque centre, rebuilt after earthquakes, is known for the elephant fountain, a fish market, and Etna excursions inland.
- Mount Etna
- Baroque centre
- Fish market
- Day12
Sorrento
Arrive 07:00 · Depart 19:00
A clifftop town on Italy's Bay of Naples, perched above the sea facing Vesuvius. Sorrento is known for its lemon groves and limoncello, a tangle of narrow shopping lanes, and its role as a base for Capri, Pompeii, and the Amalfi Coast.
- Marina Grande
- Lemon groves
- Piazza Tasso
- Day13
Civitavecchia
Arrive 07:00 · Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 28 Jun 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Europe Cruise from Istanbul FAQ
Which ports does this cruise visit?
This 12-night Europe cruise calls at Istanbul, Mytilene, Lesbos, Kusadasi, Heraklion (Iraklion), Crete, Cruising the Ionian Sea, Dubrovnik, Kotor, Corfu, Valletta, Catania, Sorrento and Civitavecchia.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Istanbul and ends in Civitavecchia.
How long is this cruise?
12 nights aboard Seven Seas Voyager.
When does this itinerary sail?
Upcoming departures include 28 Jun 2026. A NestCruise advisor can confirm current availability.