Cruise itinerary
22-Night Europe Cruise from Istanbul
22 nights · Europe · 22 ports of call
22-night Europe cruise aboard Seven Seas Voyager, departing Istanbul and calling at Mytilene, Lesbos, Kusadasi, Heraklion (Iraklion), Crete, Cruising the Ionian Sea, Dubrovnik and Kotor and 15 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 22 nights
- Region
- Europe · Southern Europe · Mediterranean
- Departs
- Istanbul
- Returns
- Lisbon
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Voyager sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Istanbul
Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day2
Mytilene, Lesbos
Arrive 09:00 · Depart 18:00
- Day3
Kusadasi
Arrive 08:00 · Depart 17:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day4
Heraklion (Iraklion), Crete
Arrive 08:00 · Depart 17:00
The largest city on Crete and the island's main port, in Greece. A Venetian harbour and fortress front the town, while the Bronze Age palace of Knossos and the Heraklion Archaeological Museum's Minoan treasures lie close by.
- Palace of Knossos
- Venetian harbour
- Archaeological Museum
- Day5
Cruising the Ionian Sea
- Day6
Dubrovnik
Arrive 08:00 · Depart 18:00
A walled city on Croatia's Dalmatian coast, its limestone old town wrapped in sea-facing ramparts above the Adriatic. Ships call here for the marble main street of Stradun, the circuit of the city walls and the cable car to Mount Srđ.
- City walls
- Stradun
- Mount Srđ cable car
- Day7
Kotor
Arrive 08:00 · Depart 16:00
A walled medieval town at the head of the Bay of Kotor, a fjord-like inlet of the Adriatic ringed by steep mountains. Ships anchor below the old town, whose stone lanes and ramparts climb toward the fortress of San Giovanni.
- Bay of Kotor
- Old town walls
- San Giovanni fortress
- Day8
Corfu
Arrive 09:00 · Depart 18:00
An Ionian island off Greece's northwest coast, greener and more Venetian-feeling than the Aegean isles. Ships call at its old town, a UNESCO-listed warren of Italianate streets between two hilltop fortresses, with pebbly coves around the shore.
- Old Fortress
- Liston arcade
- Ionian coves
- Day9
Cruising the Ionian Sea
- Day10
Valletta
Arrive 07:00 · Depart 17:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day11
Catania
Arrive 07:00 · Depart 16:00
A port city on the east coast of Sicily, built in dark volcanic stone beneath Mount Etna, Europe's most active volcano. Its baroque centre, rebuilt after earthquakes, is known for the elephant fountain, a fish market, and Etna excursions inland.
- Mount Etna
- Baroque centre
- Fish market
- Day12
Sorrento
Arrive 07:00 · Depart 19:00
A clifftop town on Italy's Bay of Naples, perched above the sea facing Vesuvius. Sorrento is known for its lemon groves and limoncello, a tangle of narrow shopping lanes, and its role as a base for Capri, Pompeii, and the Amalfi Coast.
- Marina Grande
- Lemon groves
- Piazza Tasso
- Day13
Civitavecchia
Arrive 07:00 · Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day14
Livorno
Arrive 07:00 · Depart 19:00
A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
- Gateway to Florence
- Pisa excursions
- Venezia Nuova canals
- Day15
Toulon
Arrive 09:00 · Depart 18:00
A major French naval port on the Mediterranean, set on a wide harbour beneath the heights of Mont Faron. Its old town and Provençal market lie behind the waterfront, and a cable car climbs the mountain for sweeping views over the roadstead.
- Mont Faron
- Provençal market
- Naval harbour
- Day16
Barcelona
Arrive 09:00 · Depart 19:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day17
Palma de Mallorca
Arrive 08:00 · Depart 17:00
The capital of Mallorca in Spain's Balearic Islands, set around a wide bay. Its enormous seafront cathedral, La Seu, rises above the old town's narrow lanes, with a hilltop castle, marina and nearby coves a short way from the cruise terminal.
- La Seu cathedral
- Bellver Castle
- Old town
- Day18
Cruising the Mediterranean Sea
- Day19
Málaga
Arrive 08:00 · Depart 20:00
A port city on Spain's Costa del Sol and the birthplace of Picasso. Cruise ships berth near the centre, where a hilltop Moorish fortress, the cathedral and the Picasso Museum sit close to broad city beaches and fried-fish chiringuitos.
- Alcazaba fortress
- Picasso Museum
- Costa del Sol beaches
- Day20
Gibraltar
Arrive 08:00 · Depart 21:00
A British territory at the southern tip of Spain, dominated by its towering limestone Rock. Cable cars climb to the summit, home to Europe's only wild monkeys, with sweeping views across the strait toward the coast of Africa.
- The Rock
- Barbary macaques
- St. Michael's Cave
- Day21
Sailing the Atlantic Ocean
- Day22
Portimão
Arrive 08:00 · Depart 18:00
A port town on the Algarve coast of southern Portugal, set at the mouth of the Arade River. It is known for grilled sardines and the golden cliffs and caves of nearby Praia da Rocha, one of the region's longest beaches.
- Praia da Rocha
- Grilled sardines
- Arade River
- Day23
Lisbon
Arrive 07:00 · Depart 19:00
Portugal's hilly capital, spread across seven hills above the Tagus estuary. Yellow trams climb to the Alfama's tangled lanes and the Castle of São Jorge, while Belém's monastery and pastéis de nata anchor the riverside to the west.
- Alfama district
- Belém Tower
- Tram 28
Upcoming departures
- 28 Jun 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Europe Cruise from Istanbul FAQ
Which ports does this cruise visit?
This 22-night Europe cruise calls at Istanbul, Mytilene, Lesbos, Kusadasi, Heraklion (Iraklion), Crete, Cruising the Ionian Sea, Dubrovnik, Kotor, Corfu, Valletta, Catania, Sorrento, Civitavecchia, Livorno, Toulon, Barcelona, Palma de Mallorca, Cruising the Mediterranean Sea, Málaga, Gibraltar, Sailing the Atlantic Ocean, Portimão and Lisbon.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Istanbul and ends in Lisbon.
How long is this cruise?
22 nights aboard Seven Seas Voyager.
When does this itinerary sail?
Upcoming departures include 28 Jun 2026. A NestCruise advisor can confirm current availability.