Cruise itinerary
21-Night South America Cruise from Rio de Janeiro
21 nights · South America · 9 ports of call
21-night South America cruise aboard Oceania Insignia, departing Rio de Janeiro and calling at Santarém, Boca da Valeria, Manaus, Parintins, Bridgetown and Antigua and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Insignia
- Cruise line
- Oceania Cruises
- Duration
- 21 nights
- Region
- South America
- Departs
- Rio de Janeiro
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Insignia sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Rio de Janeiro
Depart 16:00
Brazil's great coastal city, set between forested mountains and the Atlantic. The Christ the Redeemer statue looks down from Corcovado, Sugarloaf rises over the harbour mouth, and the sands of Copacabana and Ipanema run along the city's southern edge.
- Christ the Redeemer
- Sugarloaf Mountain
- Copacabana Beach
- Day2At sea
- Day3At sea
- Day4At sea
- Day5At sea
- Day6At sea
- Day7At sea
- Day8
Santarém
Arrive 14:00 · Depart 20:00
- Day9
Boca da Valeria
Arrive 08:00 · Depart 15:00
- Day10
Manaus
Arrive 09:00 · Depart 18:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day11At sea
- Day12
Parintins
Arrive 12:00 · Depart 18:00
- Day13
Santarém
Arrive 07:00 · Depart 12:00
- Day14At sea
- Day15At sea
- Day16At sea
- Day17
Bridgetown
Arrive 07:00 · Depart 15:00
The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
- Carlisle Bay
- Garrison Savannah
- Rum distilleries
- Day18
Antigua
Arrive 11:00 · Depart 18:00
- Day19
Saint Thomas
Arrive 07:00 · Depart 17:00
An island in the U.S. Virgin Islands known for its deep harbour at Charlotte Amalie and its red-roofed hillsides. It offers duty-free shopping along the waterfront, the beach at Magens Bay, and a short ferry hop to quieter St. John.
- Magens Bay
- Charlotte Amalie
- Ferry to St. John
- Day20At sea
- Day21At sea
- Day22
Miami, Florida
Arrive 08:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 19 Mar 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night South America Cruise from Rio de Janeiro FAQ
Which ports does this cruise visit?
This 21-night South America cruise calls at Rio de Janeiro, Santarém, Boca da Valeria, Manaus, Parintins, Bridgetown, Antigua, Saint Thomas and Miami, Florida.
How many days are spent at sea?
12 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Rio de Janeiro and ends in Miami, Florida.
How long is this cruise?
21 nights aboard Oceania Insignia.
When does this itinerary sail?
Upcoming departures include 19 Mar 2027. A NestCruise advisor can confirm current availability.