Crystal Serenity — 41-Night South America Cruise from Buenos Aires

Cruise itinerary

41-Night South America Cruise from Buenos Aires

41 nights · South America · 26 ports of call

41-night South America cruise aboard Crystal Serenity, departing Buenos Aires and calling at Punta del Este, Puerto Madryn, Port Stanley, Ushuaia, Punta Arenas and Chilean Fjords and 19 more.

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At a glance

Ship: Crystal Serenity
Cruise line: Crystal
Duration: 41 nights
Region: South America
Departs: Buenos Aires
Returns: Fort Lauderdale, Florida

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Crystal Serenity sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Buenos Aires
  Depart 19:00
  Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
  - La Boca
  - San Telmo
  - Tango culture
Day
2
- Punta del Este
  Arrive 08:00 · Depart 17:00
Day
3
At sea
Day
4
- Puerto Madryn
  Arrive 09:00 · Depart 19:00
  A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
  - Península Valdés
  - Whale watching
  - Welsh heritage
Day
5
At sea
Day
6
- Port Stanley
  Arrive 08:00 · Depart 18:00
  The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
  - Penguin colonies
  - Whalebone Arch
  - Christ Church Cathedral
Day
7
At sea
Day
8
- Ushuaia
  Arrive 07:00 · Depart 19:00
  The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
  - Beagle Channel
  - Tierra del Fuego park
  - End of the world
Day
9
- Punta Arenas
  Arrive 13:00 · Depart 19:00
  A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
  - Strait of Magellan
  - Plaza de Armas
  - Penguin colonies
Day
10
At sea
Day
11
- Chilean Fjords
  Arrive 18:00 · Depart 18:00
Day
12
At sea
Day
13
At sea
Day
14
- Puerto Chacabuco
  Arrive 08:00 · Depart 17:00
Day
15
- Chiloe Island Chile
  Arrive 09:00 · Depart 18:00
Day
16
- Puerto Montt
  Arrive 08:00 · Depart 18:00
  A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
  - Osorno Volcano
  - Puerto Varas
  - Angelmó market
Day
17
At sea
Day
18
- Valparaiso
  Arrive 08:00 · Depart 19:00
  A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
  - Hillside funiculars
  - Cerro Concepción
  - Casablanca wineries
Day
19
At sea
Day
20
- Coquimbo
  Arrive 09:00 · Depart 18:00
Day
21
At sea
Day
22
- Iquique
  Arrive 08:00 · Depart 18:00
Day
23
At sea
Day
24
- Pisco
  Arrive 08:00 · Depart 18:00
Day
25
- Callao
  Arrive 07:00 · Depart 19:00
  Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
  - Gateway to Lima
  - Miraflores
  - Historic centre
Day
26
- Salaverry
  Arrive 11:00 · Depart 20:00
Day
27
At sea
Day
28
- Guayaquil
  Arrive 07:00 · Depart 19:00
Day
29
At sea
Day
30
- Panama City
  Arrive 17:00 · Depart 04:00
  Panama's capital, where a glass-tower skyline meets the Pacific entrance to the famous canal. The colonial Casco Viejo quarter holds plazas and churches, while the Miraflores locks and the rainforest of Soberanía National Park sit close by.
  - Panama Canal
  - Casco Viejo
  - Miraflores Locks
Day
31
At sea
Day
32
- Panama Canal Transit
Day
33
- Puerto Limón
  Arrive 08:00 · Depart 18:00
  A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
  - Tortuguero canals
  - Rainforest wildlife
  - Banana country
Day
34
At sea
Day
35
- Roatán Island
  Arrive 08:00 · Depart 18:00
  An island off the northern coast of Honduras in the western Caribbean, part of the Bay Islands. Roatán is known for the Mesoamerican Barrier Reef just offshore, the dive sites and beaches around West End and West Bay, and forested inland hills.
  - West Bay Beach
  - Barrier reef diving
  - West End
Day
36
- Santo Tomás de Castilla
  Arrive 08:00 · Depart 18:00
Day
37
- Belize City
  Arrive 08:00 · Depart 18:00
  The largest city in Belize, on the Caribbean coast where the Belize River meets the sea. A tender port for many ships, it opens the way to the world's second-largest barrier reef, jungle Maya ruins and cave-tubing excursions inland.
  - Barrier reef
  - Maya ruins
  - Cave tubing
Day
38
- Cozumel
  Arrive 09:00 · Depart 17:00
  An island off Mexico's Yucatán coast in the Caribbean, a leading port for snorkelling and diving. Ships dock beside its reefs, part of the Mesoamerican system, with beach clubs, Mayan ruins and the resort strip of the Riviera Maya within reach.
  - Coral reefs
  - Mayan ruins
  - Beach clubs
Day
39
At sea
Day
40
- Progreso
  Arrive 08:00 · Depart 18:00
Day
41
At sea
Day
42
- Fort Lauderdale, Florida
  Arrive 07:00
  A South Florida port often called the yachting capital, fringed by canals and the long sands of Fort Lauderdale Beach. Port Everglades is among the world's busiest cruise gateways, with Las Olas Boulevard's shops and cafés minutes from the piers.
  - Port Everglades
  - Las Olas Boulevard
  - Fort Lauderdale Beach

Upcoming departures

11 Nov 2027

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

41-Night South America Cruise from Buenos Aires FAQ

Which ports does this cruise visit?

This 41-night South America cruise calls at Buenos Aires, Punta del Este, Puerto Madryn, Port Stanley, Ushuaia, Punta Arenas, Chilean Fjords, Puerto Chacabuco, Chiloe Island Chile, Puerto Montt, Valparaiso, Coquimbo, Iquique, Pisco, Callao, Salaverry, Guayaquil, Panama City, Panama Canal Transit, Puerto Limón, Roatán Island, Santo Tomás de Castilla, Belize City, Cozumel, Progreso and Fort Lauderdale, Florida.

How many days are spent at sea?

16 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Buenos Aires and ends in Fort Lauderdale, Florida.

How long is this cruise?

41 nights aboard Crystal Serenity.

When does this itinerary sail?

Upcoming departures include 11 Nov 2027. A NestCruise advisor can confirm current availability.

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