Cruise itinerary
27-Night Mediterranean Cruise from Lisbon
27 nights · Mediterranean · 22 ports of call
27-night Mediterranean cruise aboard Crystal Serenity, departing Lisbon and calling at Portimão, Cádiz, Valencia, Port-Vendres, Ajaccio, Corsica and Livorno and 15 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Crystal Serenity
- Cruise line
- Crystal
- Duration
- 27 nights
- Region
- Mediterranean
- Departs
- Lisbon
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Crystal Serenity sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Lisbon
Depart 19:00
Portugal's hilly capital, spread across seven hills above the Tagus estuary. Yellow trams climb to the Alfama's tangled lanes and the Castle of São Jorge, while Belém's monastery and pastéis de nata anchor the riverside to the west.
- Alfama district
- Belém Tower
- Tram 28
- Day2
Portimão
Arrive 08:00 · Depart 17:00
A port town on the Algarve coast of southern Portugal, set at the mouth of the Arade River. It is known for grilled sardines and the golden cliffs and caves of nearby Praia da Rocha, one of the region's longest beaches.
- Praia da Rocha
- Grilled sardines
- Arade River
- Day3
Cádiz
Arrive 07:00 · Depart 20:00
One of the oldest continuously inhabited cities in Western Europe, set on a narrow spit almost surrounded by the Atlantic in Spain's Andalusia. A gold-domed cathedral rises over the old town's tight lanes, sea walls and the long sands of La Caleta.
- Cádiz Cathedral
- La Caleta beach
- Old town lanes
- Day4At sea
- Day5
Valencia
Arrive 07:00 · Depart 17:00
Spain's third city, on the Mediterranean coast where the old riverbed has become a long ribbon of parkland. It is the birthplace of paella, home to the silk-era Lonja trading hall and to Calatrava's white City of Arts and Sciences complex.
- City of Arts and Sciences
- La Lonja
- Paella
- Day6
Port-Vendres
Arrive 08:00 · Depart 17:00
- Day7
Ajaccio, Corsica
Arrive 09:00 · Depart 18:00
The capital of Corsica and Napoleon's birthplace, set on a sheltered gulf on the island's west coast. Ajaccio is known for its Bonaparte family house, the citadel and old town, and the rugged Sanguinaires islands off the harbour mouth.
- Maison Bonaparte
- Sanguinaires islands
- Ajaccio citadel
- Day8
Livorno
Arrive 07:00 · Depart 19:00
A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
- Gateway to Florence
- Pisa excursions
- Venezia Nuova canals
- Day9
Civitavecchia
Arrive 19:00 · Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day10
Salerno
Arrive 08:00 · Depart 18:00
An Italian port at the head of its own gulf, just south of the Amalfi Coast. Its long seafront and walkable medieval centre make it a quieter base for reaching Pompeii, Paestum's Greek temples and the cliffside towns of Amalfi and Positano.
- Amalfi Coast gateway
- Paestum temples
- Seafront promenade
- Day11
Siracusa, Sicily
Arrive 09:00 · Depart 19:00
- Day12
Valletta
Arrive 08:00 · Depart 19:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day13At sea
- Day14
Soúda, Crete
Arrive 07:00 · Depart 17:00
The port of Chania on the northwest coast of Crete, set beside Souda Bay, one of the Mediterranean's deepest natural harbours. It opens onto the old Venetian quarter of Chania, with its lighthouse, harbour-front, and lanes of the former Turkish town.
- Chania old town
- Venetian lighthouse
- Souda Bay
- Day15
Nafplio
Arrive 08:00 · Depart 18:00
- Day16
Syros
Arrive 08:00 · Depart 18:00
- Day17
Piraeus
Arrive 19:00 · Depart 19:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day18
Naxos
Arrive 08:00 · Depart 18:00
- Day19
Monemvasía
Arrive 08:00 · Depart 17:00
A fortified medieval town clinging to a tied island off the southeastern Peloponnese in Greece. A causeway links it to a lower town of Byzantine churches and stone lanes, with a ruined upper citadel crowning the rock above the Aegean.
- Lower town
- Byzantine churches
- Upper fortress
- Day20At sea
- Day21
La Goulette
Arrive 08:00 · Depart 20:00
The port of Tunis on the Gulf of Tunis in Tunisia, the usual landing for ships calling at the capital. The ancient ruins of Carthage and the blue-and-white clifftop village of Sidi Bou Saïd lie close by, with the city's great walled medina a short drive away.
- Carthage ruins
- Sidi Bou Saïd
- Tunis medina
- Day22
Cagliari
Arrive 08:00 · Depart 17:00
The capital of Sardinia, an Italian port set across hills above the Gulf of the Angels. Its fortified Castello quarter looks down over the harbour, with a long city beach at Poetto and the Roman amphitheatre among its older landmarks.
- Castello quarter
- Poetto Beach
- Roman amphitheatre
- Day23
Ajaccio, Corsica
Arrive 09:00 · Depart 18:00
The capital of Corsica and Napoleon's birthplace, set on a sheltered gulf on the island's west coast. Ajaccio is known for its Bonaparte family house, the citadel and old town, and the rugged Sanguinaires islands off the harbour mouth.
- Maison Bonaparte
- Sanguinaires islands
- Ajaccio citadel
- Day24
Monte-Carlo
Arrive 08:00 · Depart 21:00
The seafront quarter of Monaco on the French Riviera, set on a rocky terrace above the Mediterranean. It is known for the belle-époque Casino, the Hôtel de Paris and the harbour that hosts the Monaco Grand Prix each spring.
- Casino de Monte-Carlo
- Port Hercule
- Grand Prix circuit
- Day25At sea
- Day26
Toulon
Arrive 08:00 · Depart 18:00
A major French naval port on the Mediterranean, set on a wide harbour beneath the heights of Mont Faron. Its old town and Provençal market lie behind the waterfront, and a cable car climbs the mountain for sweeping views over the roadstead.
- Mont Faron
- Provençal market
- Naval harbour
- Day27At sea
- Day28
Barcelona
Arrive 06:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 5 May 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
27-Night Mediterranean Cruise from Lisbon FAQ
Which ports does this cruise visit?
This 27-night Mediterranean cruise calls at Lisbon, Portimão, Cádiz, Valencia, Port-Vendres, Ajaccio, Corsica, Livorno, Civitavecchia, Salerno, Siracusa, Sicily, Valletta, Soúda, Crete, Nafplio, Syros, Piraeus, Naxos, Monemvasía, La Goulette, Cagliari, Monte-Carlo, Toulon and Barcelona.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Lisbon and ends in Barcelona.
How long is this cruise?
27 nights aboard Crystal Serenity.
When does this itinerary sail?
Upcoming departures include 5 May 2028. A NestCruise advisor can confirm current availability.