Cruise itinerary
15-Night Panama Canal Cruise from Miami, Florida
15 nights · Panama Canal · 9 ports of call
15-night Panama Canal cruise aboard Oceania Vista, departing Miami, Florida and calling at Grand Cayman, Cartagena, Panama Canal Transit, Puerto Quetzal, Acapulco and Manzanillo, Mexico and 2 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Vista
- Cruise line
- Oceania Cruises
- Duration
- 15 nights
- Region
- Panama Canal
- Departs
- Miami, Florida
- Returns
- Los Angeles, California
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Vista sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Depart 16:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2At sea
- Day3
Grand Cayman
Arrive 09:00 · Depart 17:00
The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
- Seven Mile Beach
- Stingray City
- George Town
- Day4At sea
- Day5
Cartagena
Arrive 08:00 · Depart 15:00
A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
- Walled old town
- San Felipe fortress
- Plaza Santo Domingo
- Day6
Panama Canal Transit
- Day7At sea
- Day8At sea
- Day9
Puerto Quetzal
Arrive 07:00 · Depart 18:00
Guatemala's main Pacific port, a working harbour backed by volcanic highlands. It opens the way to colonial Antigua with its cobbled streets and ruined convents, the coffee farms on the slopes and Lake Atitlán's volcano-ringed shore.
- Antigua Guatemala
- Lake Atitlán
- Coffee plantations
- Day10At sea
- Day11
Acapulco
Arrive 07:00 · Depart 14:00
- Day12
Manzanillo, Mexico
Arrive 09:00 · Depart 16:00
- Day13At sea
- Day14At sea
- Day15
San Diego, California
Arrive 12:00 · Depart 22:00
A relaxed harbour city in southern California, known for its mild climate and broad natural bay. The waterfront holds the historic Gaslamp Quarter and maritime museums, with the green expanse of Balboa Park and its zoo just inland.
- Balboa Park
- Gaslamp Quarter
- San Diego Zoo
- Day16
Los Angeles, California
Arrive 08:00
The sprawling Pacific gateway of southern California, with most cruises sailing from the neighbouring Port of Los Angeles at San Pedro. The morning leaves time for Hollywood, the beaches at Santa Monica or the galleries downtown before departure.
- Hollywood
- Santa Monica Pier
- Getty Center
Upcoming departures
- 6 Jan 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
15-Night Panama Canal Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 15-night Panama Canal cruise calls at Miami, Florida, Grand Cayman, Cartagena, Panama Canal Transit, Puerto Quetzal, Acapulco, Manzanillo, Mexico, San Diego, California and Los Angeles, California.
How many days are spent at sea?
7 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Miami, Florida and ends in Los Angeles, California.
How long is this cruise?
15 nights aboard Oceania Vista.
When does this itinerary sail?
Upcoming departures include 6 Jan 2027. A NestCruise advisor can confirm current availability.