Oceania Sirena — 65-Night South America Cruise from Miami, Florida

Cruise itinerary

65-Night South America Cruise from Miami, Florida

65 nights · South America · 32 ports of call

65-night South America cruise aboard Oceania Sirena, departing Miami, Florida and calling at Grand Cayman, Ocho Rios, Santa Marta Colombia, Cartagena, Colón and Panama Canal Transit and 25 more.

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At a glance

Ship: Oceania Sirena
Cruise line: Oceania Cruises
Duration: 65 nights
Region: South America
Departs: Miami, Florida
Returns: Miami, Florida

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Sirena sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Miami, Florida
  Depart 17:00
  The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
  - South Beach
  - Little Havana
  - Wynwood murals
Day
2
At sea
Day
3
- Grand Cayman
  Arrive 11:00 · Depart 18:00
  The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
  - Seven Mile Beach
  - Stingray City
  - George Town
Day
4
- Ocho Rios
  Arrive 11:00 · Depart 20:00
  A resort town on Jamaica's north coast, set among green hills and a string of beaches. The terraced cascades of Dunn's River Falls are the headline attraction, with botanical gardens, river tubing and reggae-filled markets close to the cruise pier.
  - Dunn's River Falls
  - Resort beaches
  - Botanical gardens
Day
5
At sea
Day
6
- Santa Marta Colombia
  Arrive 07:00 · Depart 17:00
Day
7
- Cartagena
  Arrive 07:00 · Depart 13:00
  A walled colonial city on Colombia's Caribbean coast, its old town a maze of pastel houses, balconies and shaded plazas. Massive stone ramparts ring the centre, with the San Felipe fortress guarding the harbour above.
  - Walled old town
  - San Felipe fortress
  - Plaza Santo Domingo
Day
8
- Colón
  Arrive 08:00 · Depart 20:00
  A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
  - Gatún Locks
  - Panama Canal
  - Portobelo forts
Day
9
- Panama Canal Transit
Day
10
At sea
Day
11
- Manta
  Arrive 07:00 · Depart 17:00
Day
12
At sea
Day
13
- Salaverry
  Arrive 07:00 · Depart 16:00
Day
14
- Callao
  Arrive 11:00 · Depart 17:00
  Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
  - Gateway to Lima
  - Miraflores
  - Historic centre
Day
15
At sea
Day
16
- Pisco
  Arrive 08:00 · Depart 17:00
Day
17
At sea
Day
18
- Arica
  Arrive 07:00 · Depart 17:00
Day
19
At sea
Day
20
- Antofagasta
  Arrive 07:00 · Depart 17:00
Day
21
At sea
Day
22
- Valparaiso
  Arrive 07:00 · Depart 16:00
  A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
  - Hillside funiculars
  - Cerro Concepción
  - Casablanca wineries
Day
23
At sea
Day
24
- Puerto Montt
  Arrive 09:00 · Depart 18:00
  A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
  - Osorno Volcano
  - Puerto Varas
  - Angelmó market
Day
25
- Chiloe Island Chile
  Arrive 07:00 · Depart 16:00
Day
26
- Puerto Chacabuco
  Arrive 09:00 · Depart 18:00
Day
27
At sea
Day
28
At sea
Day
29
- Punta Arenas
  Arrive 07:00 · Depart 17:00
  A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
  - Strait of Magellan
  - Plaza de Armas
  - Penguin colonies
Day
30
- Ushuaia
  Arrive 11:00 · Depart 20:00
  The world's southernmost city, on Argentina's Tierra del Fuego at the tip of South America. Backed by snowy peaks on the Beagle Channel, it is the chief departure port for Antarctica and a base for the Patagonian wilderness.
  - Beagle Channel
  - Tierra del Fuego park
  - End of the world
Day
31
At sea
Day
32
At sea
Day
33
At sea
Day
34
At sea
Day
35
At sea
Day
36
- Port Stanley
  Arrive 07:00 · Depart 16:00
  The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
  - Penguin colonies
  - Whalebone Arch
  - Christ Church Cathedral
Day
37
At sea
Day
38
- Puerto Madryn
  Arrive 08:00 · Depart 17:00
  A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
  - Península Valdés
  - Whale watching
  - Welsh heritage
Day
39
At sea
Day
40
At sea
Day
41
- Buenos Aires
  Arrive 05:00 · Depart 18:00
  Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
  - La Boca
  - San Telmo
  - Tango culture
Day
42
- Punta del Este
  Arrive 08:00 · Depart 18:00
Day
43
At sea
Day
44
At sea
Day
45
- Rio de Janeiro
  Arrive 07:00 · Depart 17:00
  Brazil's great coastal city, set between forested mountains and the Atlantic. The Christ the Redeemer statue looks down from Corcovado, Sugarloaf rises over the harbour mouth, and the sands of Copacabana and Ipanema run along the city's southern edge.
  - Christ the Redeemer
  - Sugarloaf Mountain
  - Copacabana Beach
Day
46
At sea
Day
47
At sea
Day
48
- Maceió
  Arrive 07:00 · Depart 17:00
  The capital of Alagoas on Brazil's north-east coast, fringed by white sand and warm reef-protected lagoons. Pajuçara and Ponta Verde beaches draw swimmers, and jangada rafts carry visitors out to the natural tidal pools offshore.
  - Pajuçara beach
  - Natural pools
  - Jangada rafts
Day
49
At sea
Day
50
At sea
Day
51
At sea
Day
52
At sea
Day
53
- Santarém
  Arrive 08:00 · Depart 17:00
Day
54
- Boca da Valeria
  Arrive 07:00 · Depart 14:00
Day
55
- Manaus
  Arrive 09:00 · Depart 17:00
  The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
  - Amazonas Opera House
  - Meeting of the Waters
  - Adolpho Lisboa Market
Day
56
At sea
Day
57
- Parintins
  Arrive 10:00 · Depart 18:00
Day
58
At sea
Day
59
At sea
Day
60
At sea
Day
61
- Bridgetown
  Arrive 09:00 · Depart 17:00
  The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
  - Carlisle Bay
  - Garrison Savannah
  - Rum distilleries
Day
62
- Pointe-à-Pitre
  Arrive 09:00 · Depart 17:00
  The main town of Guadeloupe, a French overseas region in the eastern Caribbean shaped like a butterfly. It sits between the two wings of the island, with a covered spice market, Creole cooking and the volcano of La Soufrière to the south.
  - Spice market
  - La Soufrière
  - Memorial ACTe
Day
63
- Tortola
  Arrive 10:00 · Depart 17:00
  The main island of the British Virgin Islands, where steep green hills drop to a yacht-filled harbour at Road Town. It is a noted sailing base in the Caribbean, with quiet bays such as Cane Garden and ferries out to neighbouring Virgin Gorda.
  - Road Town
  - Cane Garden Bay
  - Sailing charters
Day
64
At sea
Day
65
At sea
Day
66
- Miami, Florida
  Arrive 08:00
  The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
  - South Beach
  - Little Havana
  - Wynwood murals

Upcoming departures

5 Jan 2028

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

65-Night South America Cruise from Miami, Florida FAQ

Which ports does this cruise visit?

This 65-night South America cruise calls at Miami, Florida, Grand Cayman, Ocho Rios, Santa Marta Colombia, Cartagena, Colón, Panama Canal Transit, Manta, Salaverry, Callao, Pisco, Arica, Antofagasta, Valparaiso, Puerto Montt, Chiloe Island Chile, Puerto Chacabuco, Punta Arenas, Ushuaia, Port Stanley, Puerto Madryn, Buenos Aires, Punta del Este, Rio de Janeiro, Maceió, Santarém, Boca da Valeria, Manaus, Parintins, Bridgetown, Pointe-à-Pitre and Tortola.

How many days are spent at sea?

33 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It is a round-trip sailing from Miami, Florida.

How long is this cruise?

65 nights aboard Oceania Sirena.

When does this itinerary sail?

Upcoming departures include 5 Jan 2028. A NestCruise advisor can confirm current availability.

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