Cruise itinerary
22-Night Europe Cruise from Southampton
22 nights · Europe · 22 ports of call
22-night Europe cruise aboard Oceania Sirena, departing Southampton and calling at At Sea, Le Verdon-sur-Mer, Saint-Jean-de-Luz, Santander, Ferrol and Porto and 15 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Sirena
- Cruise line
- Oceania Cruises
- Duration
- 22 nights
- Region
- Europe · Southern Europe · Mediterranean · Western Europe
- Departs
- Southampton
- Returns
- Istanbul
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Sirena sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Southampton
Arrive 05:00 · Depart 17:00
England's principal cruise homeport on the south coast, with deep docks that once launched the great ocean liners. Many transatlantic and Northern European sailings begin here, an hour or so by rail from London and close to the New Forest.
- Ocean liner heritage
- Gateway to London
- Tudor old town
- Day2
At Sea
- Day3
Le Verdon-sur-Mer
Arrive 07:00 · Depart 19:00
- Day4
Saint-Jean-de-Luz
Arrive 07:00 · Depart 17:00
- Day5
Santander
Arrive 07:00 · Depart 15:00
- Day6
Ferrol
Arrive 08:00 · Depart 17:00
- Day7
Porto
Arrive 09:00 · Depart 17:00
Portugal's second city, climbing the granite hillsides above the Douro as it nears the Atlantic. It gives port wine its name; the riverside Ribeira district, the Dom Luís I iron bridge and the cellars of Vila Nova de Gaia define the waterfront.
- Ribeira district
- Dom Luís I Bridge
- Port wine cellars
- Day8
Lisbon
Arrive 07:00 · Depart 15:00
Portugal's hilly capital, spread across seven hills above the Tagus estuary. Yellow trams climb to the Alfama's tangled lanes and the Castle of São Jorge, while Belém's monastery and pastéis de nata anchor the riverside to the west.
- Alfama district
- Belém Tower
- Tram 28
- Day9
Seville
Arrive 11:00 · Depart 21:00
Andalusia's historic capital, reached by river barge up the Guadalquivir in southern Spain. The vast Gothic cathedral, the Moorish Alcázar palace and the dancing of flamenco define a city once enriched by trade with the New World.
- Seville Cathedral
- Royal Alcázar
- Flamenco
- Day10
Málaga
Arrive 08:00 · Depart 20:00
A port city on Spain's Costa del Sol and the birthplace of Picasso. Cruise ships berth near the centre, where a hilltop Moorish fortress, the cathedral and the Picasso Museum sit close to broad city beaches and fried-fish chiringuitos.
- Alcazaba fortress
- Picasso Museum
- Costa del Sol beaches
- Day11
Almería
Arrive 07:00 · Depart 17:00
- Day12
Alicante
Arrive 07:00 · Depart 15:00
A sun-warmed port on Spain's Costa Blanca, set below the Santa Bárbara castle on its rocky headland. The palm-lined Explanada promenade leads to a long city beach, with the old Barrio Santa Cruz climbing the hill in white houses.
- Santa Bárbara Castle
- Explanada promenade
- Postiguet Beach
- Day13
Barcelona
Arrive 06:00 · Depart 17:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day14
At Sea
- Day15
Palermo
Arrive 07:00 · Depart 17:00
The capital of Sicily, a port city layered with Arab, Norman, and Baroque history on the island's north coast. Palermo is known for its mosaic-rich Cappella Palatina, lively street-food markets, and the Norman cathedral at nearby Monreale.
- Cappella Palatina
- Ballarò market
- Monreale mosaics
- Day16
Siracuse, Sicily
Arrive 07:00 · Depart 15:00
A historic city on the southeast coast of Sicily, once among the greatest powers of the ancient Greek world. The island of Ortigia holds its baroque core and a temple-turned-cathedral, beside a vast archaeological park with a Greek theatre.
- Ortigia island
- Greek theatre
- Baroque cathedral
- Day17
Argostoli
Arrive 09:00 · Depart 18:00
The capital of Kefalonia, the largest of Greece's Ionian Islands. Rebuilt after a 1953 earthquake, the waterfront town curves around a sheltered lagoon and serves as a base for the island's pale-pebble beaches, caves and the white sand of Myrtos.
- Myrtos Beach
- Melissani Cave
- Koutavos lagoon
- Day18
Gythio
Arrive 08:00 · Depart 18:00
A coastal town in the southern Peloponnese of Greece, set on the Laconian Gulf below the Taygetos mountains. A causeway leads to the islet of Cranae, and the abandoned Byzantine hill city of Mystras lies inland near ancient Sparta.
- Cranae islet
- Mystras
- Mani peninsula
- Day19
Páros
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean Sea, known for its white marble and laid-back harbour villages. The old port of Parikia and the fishing village of Naoussa anchor a landscape of whitewashed lanes, Byzantine churches and a string of sandy bays.
- Naoussa village
- Panagia Ekatontapiliani
- Cycladic beaches
- Day20
Piraeus
Arrive 08:00 · Depart 18:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day21
Ephesus
Arrive 08:00 · Depart 18:00
- Day22
Troy National Park
Arrive 08:00 · Depart 17:00
- Day23
Istanbul
Arrive 07:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
Upcoming departures
- 5 Aug 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Europe Cruise from Southampton FAQ
Which ports does this cruise visit?
This 22-night Europe cruise calls at Southampton, At Sea, Le Verdon-sur-Mer, Saint-Jean-de-Luz, Santander, Ferrol, Porto, Lisbon, Seville, Málaga, Almería, Alicante, Barcelona, Palermo, Siracuse, Sicily, Argostoli, Gythio, Páros, Piraeus, Ephesus, Troy National Park and Istanbul.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Southampton and ends in Istanbul.
How long is this cruise?
22 nights aboard Oceania Sirena.
When does this itinerary sail?
Upcoming departures include 5 Aug 2026. A NestCruise advisor can confirm current availability.