Cruise itinerary
22-Night Europe Cruise from Southampton
22 nights · Europe · 21 ports of call
22-night Europe cruise aboard Oceania Sirena, departing Southampton and calling at Le Verdon-sur-Mer, Saint-Jean-de-Luz, Santander, Ferrol, Porto-Vecchio and Lisbon and 14 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Sirena
- Cruise line
- Oceania Cruises
- Duration
- 22 nights
- Region
- Europe
- Departs
- Southampton
- Returns
- Istanbul
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Sirena sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Southampton
Depart 17:00
England's principal cruise homeport on the south coast, with deep docks that once launched the great ocean liners. Many transatlantic and Northern European sailings begin here, an hour or so by rail from London and close to the New Forest.
- Ocean liner heritage
- Gateway to London
- Tudor old town
- Day2At sea
- Day3
Le Verdon-sur-Mer
Arrive 07:00 · Depart 19:00
- Day4
Saint-Jean-de-Luz
Arrive 07:00 · Depart 17:00
- Day5
Santander
Arrive 07:00 · Depart 15:00
- Day6
Ferrol
Arrive 08:00 · Depart 17:00
- Day7
Porto-Vecchio
Arrive 09:00 · Depart 17:00
- Day8
Lisbon
Arrive 07:00 · Depart 15:00
Portugal's hilly capital, spread across seven hills above the Tagus estuary. Yellow trams climb to the Alfama's tangled lanes and the Castle of São Jorge, while Belém's monastery and pastéis de nata anchor the riverside to the west.
- Alfama district
- Belém Tower
- Tram 28
- Day9
Cádiz
Arrive 11:00 · Depart 21:00
One of the oldest continuously inhabited cities in Western Europe, set on a narrow spit almost surrounded by the Atlantic in Spain's Andalusia. A gold-domed cathedral rises over the old town's tight lanes, sea walls and the long sands of La Caleta.
- Cádiz Cathedral
- La Caleta beach
- Old town lanes
- Day10
Málaga
Arrive 08:00 · Depart 20:00
A port city on Spain's Costa del Sol and the birthplace of Picasso. Cruise ships berth near the centre, where a hilltop Moorish fortress, the cathedral and the Picasso Museum sit close to broad city beaches and fried-fish chiringuitos.
- Alcazaba fortress
- Picasso Museum
- Costa del Sol beaches
- Day11
Almería
Arrive 07:00 · Depart 17:00
- Day12
Alicante
Arrive 07:00 · Depart 15:00
A sun-warmed port on Spain's Costa Blanca, set below the Santa Bárbara castle on its rocky headland. The palm-lined Explanada promenade leads to a long city beach, with the old Barrio Santa Cruz climbing the hill in white houses.
- Santa Bárbara Castle
- Explanada promenade
- Postiguet Beach
- Day13
Barcelona
Arrive 06:00 · Depart 17:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day14At sea
- Day15
Palermo
Arrive 07:00 · Depart 17:00
The capital of Sicily, a port city layered with Arab, Norman, and Baroque history on the island's north coast. Palermo is known for its mosaic-rich Cappella Palatina, lively street-food markets, and the Norman cathedral at nearby Monreale.
- Cappella Palatina
- Ballarò market
- Monreale mosaics
- Day16
Siracusa, Sicily
Arrive 07:00 · Depart 15:00
- Day17
Kefalonia (Argostoli), Greece
Arrive 09:00 · Depart 18:00
- Day18
Gythion
Arrive 08:00 · Depart 18:00
- Day19
Páros
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean Sea, known for its white marble and laid-back harbour villages. The old port of Parikia and the fishing village of Naoussa anchor a landscape of whitewashed lanes, Byzantine churches and a string of sandy bays.
- Naoussa village
- Panagia Ekatontapiliani
- Cycladic beaches
- Day20
Piraeus
Arrive 08:00 · Depart 18:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day21
Kusadasi
Arrive 08:00 · Depart 18:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day22
Bozcaada
Arrive 08:00 · Depart 17:00
- Day23
Istanbul
Arrive 08:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
Upcoming departures
- 5 Aug 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Europe Cruise from Southampton FAQ
Which ports does this cruise visit?
This 22-night Europe cruise calls at Southampton, Le Verdon-sur-Mer, Saint-Jean-de-Luz, Santander, Ferrol, Porto-Vecchio, Lisbon, Cádiz, Málaga, Almería, Alicante, Barcelona, Palermo, Siracusa, Sicily, Kefalonia (Argostoli), Greece, Gythion, Páros, Piraeus, Kusadasi, Bozcaada and Istanbul.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Southampton and ends in Istanbul.
How long is this cruise?
22 nights aboard Oceania Sirena.
When does this itinerary sail?
Upcoming departures include 5 Aug 2026. A NestCruise advisor can confirm current availability.