Cruise itinerary
10-Night Mediterranean Cruise from Barcelona
10 nights · Mediterranean · 10 ports of call
10-night Mediterranean cruise aboard Oceania Sirena, departing Barcelona and calling at Palermo, Siracusa, Sicily, Kefalonia (Argostoli), Greece, Gythion, Páros and Piraeus and 3 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Oceania Sirena
- Cruise line
- Oceania Cruises
- Duration
- 10 nights
- Region
- Mediterranean
- Departs
- Barcelona
- Returns
- Istanbul
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Oceania Sirena sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Barcelona
Depart 17:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
- Day2At sea
- Day3
Palermo
Arrive 07:00 · Depart 17:00
The capital of Sicily, a port city layered with Arab, Norman, and Baroque history on the island's north coast. Palermo is known for its mosaic-rich Cappella Palatina, lively street-food markets, and the Norman cathedral at nearby Monreale.
- Cappella Palatina
- Ballarò market
- Monreale mosaics
- Day4
Siracusa, Sicily
Arrive 07:00 · Depart 15:00
- Day5
Kefalonia (Argostoli), Greece
Arrive 09:00 · Depart 18:00
- Day6
Gythion
Arrive 08:00 · Depart 18:00
- Day7
Páros
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean Sea, known for its white marble and laid-back harbour villages. The old port of Parikia and the fishing village of Naoussa anchor a landscape of whitewashed lanes, Byzantine churches and a string of sandy bays.
- Naoussa village
- Panagia Ekatontapiliani
- Cycladic beaches
- Day8
Piraeus
Arrive 08:00 · Depart 18:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day9
Kusadasi
Arrive 08:00 · Depart 18:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day10
Bozcaada
Arrive 08:00 · Depart 17:00
- Day11
Istanbul
Arrive 08:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
Upcoming departures
- 17 Aug 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
10-Night Mediterranean Cruise from Barcelona FAQ
Which ports does this cruise visit?
This 10-night Mediterranean cruise calls at Barcelona, Palermo, Siracusa, Sicily, Kefalonia (Argostoli), Greece, Gythion, Páros, Piraeus, Kusadasi, Bozcaada and Istanbul.
How many days are spent at sea?
1 day is spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Barcelona and ends in Istanbul.
How long is this cruise?
10 nights aboard Oceania Sirena.
When does this itinerary sail?
Upcoming departures include 17 Aug 2026. A NestCruise advisor can confirm current availability.