

Cruise itinerary
65-Night South America Cruise from Miami, Florida
65 nights · South America · 30 ports of call
65-night South America cruise aboard Seven Seas Voyager, departing Miami, Florida and calling at Grand Cayman, Falmouth, San Andres Island Colombia, Puerto Limón, Panama Canal Transit and Manta and 23 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 65 nights
- Region
- South America
- Departs
- Miami, Florida
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Voyager sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Miami, Florida
Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2At sea
- Day3

Grand Cayman
Arrive 09:00 · Depart 17:00
The largest of the Cayman Islands, a low coral island in the western Caribbean and a noted diving and offshore-banking centre. George Town's cruise harbour sits a short ride from Seven Mile Beach and the shallow sandbar of Stingray City.
- Seven Mile Beach
- Stingray City
- George Town
- Day4

Falmouth
Arrive 08:00 · Depart 17:00
- Day5At sea
- Day6
San Andres Island Colombia
Arrive 08:00 · Depart 17:00
- Day7

Puerto Limón
Arrive 07:00 · Depart 16:00
A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
- Tortuguero canals
- Rainforest wildlife
- Banana country
- Day8
Panama Canal Transit
- Day9At sea
- Day10

Manta
Arrive 07:00 · Depart 16:00
- Day11

Guayaquil
Arrive 08:00 · Depart 17:00
- Day12At sea
- Day13

Salaverry
Arrive 07:00 · Depart 16:00
- Day14

Callao
Arrive 11:00 · Depart 17:00
Peru's chief seaport, on the Pacific beside Lima. Ships dock here for the colonial centre and museums of the capital, the cliff-top Miraflores district above the ocean, and onward journeys toward Machu Picchu and the Andean highlands.
- Gateway to Lima
- Miraflores
- Historic centre
- Day15At sea
- Day16

Pisco
Arrive 08:00 · Depart 17:00
- Day17At sea
- Day18

Arica
Arrive 08:00 · Depart 17:00
- Day19

Iquique
Arrive 08:00 · Depart 17:00
- Day20At sea
- Day21

Coquimbo
Arrive 08:00 · Depart 17:00
- Day22

Valparaiso
Arrive 07:00 · Depart 16:00
A historic port city on Chile's central coast, built across steep hills laced with funiculars and painted houses. A UNESCO World Heritage site, it serves as the gateway to Santiago and the Casablanca wine valley, with a busy working harbour below.
- Hillside funiculars
- Cerro Concepción
- Casablanca wineries
- Day23At sea
- Day24

Puerto Montt
Arrive 07:00 · Depart 16:00
A port city in Chile's Lake District, set on the Reloncaví Sound where the central valley meets the fjords of Patagonia. Snow-capped volcanoes ring the bay, and the town is a launch point for trips to lakes, the German-influenced settlement of Puerto Varas and Chiloé island.
- Osorno Volcano
- Puerto Varas
- Angelmó market
- Day25

Puerto Chacabuco
Arrive 10:00 · Depart 18:00
- Day26At sea
- Day27At sea
- Day28

Punta Arenas
Arrive 10:00 · Depart 17:00
A windswept city on the Strait of Magellan in Chilean Patagonia, one of the southernmost ports on earth. It serves as a gateway to Tierra del Fuego, Antarctic crossings and nearby penguin colonies, with a grand central plaza recalling the wool and shipping boom.
- Strait of Magellan
- Plaza de Armas
- Penguin colonies
- Day29At sea
- Day30At sea
- Day31At sea
- Day32At sea
- Day33At sea
- Day34At sea
- Day35

Port Stanley
Arrive 08:00 · Depart 16:00
The small capital of the Falkland Islands in the South Atlantic, a row of brightly painted houses and tin roofs along a sheltered harbour. Penguin colonies and windswept moorland surround the settlement, with Christ Church Cathedral and its whalebone arch at the waterfront.
- Penguin colonies
- Whalebone Arch
- Christ Church Cathedral
- Day36At sea
- Day37

Puerto Madryn
Arrive 07:00 · Depart 15:00
A Patagonian port on the Gulf of Nuevo in Argentine coastal Chubut, founded by Welsh settlers. It is the gateway to the Península Valdés nature reserve, where southern right whales, sea lions and penguins gather along the coast.
- Península Valdés
- Whale watching
- Welsh heritage
- Day38At sea
- Day39

Montevideo
Arrive 10:00 · Depart 17:30
The capital of Uruguay, set on the north bank of the broad Río de la Plata. Its old town keeps colonial plazas and a long riverside promenade, the Rambla, in a relaxed South American port city known for grilled meat and mate.
- Ciudad Vieja
- The Rambla
- Plaza Independencia
- Day40

Buenos Aires
Arrive 05:45 · Depart 18:45
Argentina's grand capital on the Río de la Plata, a city of wide boulevards and European-style architecture. The tango was born in its streets, with the colourful houses of La Boca and the cafés of San Telmo close to the waterfront.
- La Boca
- San Telmo
- Tango culture
- Day41At sea
- Day42At sea
- Day43At sea
- Day44At sea
- Day45

Rio de Janeiro
Arrive 07:30 · Depart 13:00
Brazil's great coastal city, set between forested mountains and the Atlantic. The Christ the Redeemer statue looks down from Corcovado, Sugarloaf rises over the harbour mouth, and the sands of Copacabana and Ipanema run along the city's southern edge.
- Christ the Redeemer
- Sugarloaf Mountain
- Copacabana Beach
- Day46At sea
- Day47At sea
- Day48At sea
- Day49

Recife
Arrive 07:00 · Depart 15:00
- Day50At sea
- Day51At sea
- Day52At sea
- Day53

Santarém
Arrive 13:00 · Depart 20:30
- Day54
Boca da Valeria
Arrive 07:00 · Depart 15:00
- Day55

Manaus
Arrive 09:00 · Depart 16:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day56At sea
- Day57

Parintins
Arrive 10:00 · Depart 18:00
- Day58

Santarém
Arrive 07:00 · Depart 15:00
- Day59At sea
- Day60At sea
- Day61At sea
- Day62

Castries
Arrive 11:30 · Depart 17:30
The capital of St. Lucia, tucked into a sheltered harbour on the island's northwest coast. Beyond the market town rise the rainforested interior and the iconic twin Piton peaks further south along the volcanic coastline.
- The Pitons
- Central market
- Pigeon Island
- Day63

Basseterre, Saint Kitts
Arrive 07:30 · Depart 14:00
The capital of St. Kitts, set below the green slopes of a volcanic Caribbean island. Its colonial centre circles The Circus and Independence Square, while the hilltop fortress of Brimstone Hill and a scenic railway lie out along the coast.
- Brimstone Hill Fortress
- The Circus
- Scenic railway
- Day64At sea
- Day65At sea
- Day66

Miami, Florida
Arrive 07:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 13 Jan 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
65-Night South America Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 65-night South America cruise calls at Miami, Florida, Grand Cayman, Falmouth, San Andres Island Colombia, Puerto Limón, Panama Canal Transit, Manta, Guayaquil, Salaverry, Callao, Pisco, Arica, Iquique, Coquimbo, Valparaiso, Puerto Montt, Puerto Chacabuco, Punta Arenas, Port Stanley, Puerto Madryn, Montevideo, Buenos Aires, Rio de Janeiro, Recife, Santarém, Boca da Valeria, Manaus, Parintins, Castries and Basseterre, Saint Kitts.
How many days are spent at sea?
34 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Miami, Florida.
How long is this cruise?
65 nights aboard Seven Seas Voyager.
When does this itinerary sail?
Upcoming departures include 13 Jan 2028. A NestCruise advisor can confirm current availability.