Cruise itinerary
12-Night Mediterranean Cruise from Istanbul
12 nights · Mediterranean · 9 ports of call
12-night Mediterranean cruise aboard Seven Seas Splendor, departing Istanbul and calling at Kavala, Thessaloníki, Skíathos, Piraeus, Mykonos and Heraklion (Iraklion), Crete and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 12 nights
- Region
- Mediterranean
- Departs
- Istanbul
- Returns
- Istanbul
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Splendor sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Istanbul
Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day2At sea
- Day3
Kavala
Arrive 08:00 · Depart 18:00
- Day4
Thessaloníki
Arrive 08:00 · Depart 18:00
Greece's second city, a port on the Thermaic Gulf in the north with a long Byzantine and Ottoman past. The seafront White Tower, Roman-era Rotunda and Arch of Galerius, and a celebrated food scene of mezedes mark the waterfront.
- White Tower
- Rotunda
- Roman Forum
- Day5
Skíathos
Arrive 07:00 · Depart 17:00
- Day6
Piraeus
Arrive 05:30 · Depart 19:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day7
Mykonos
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day8
Heraklion (Iraklion), Crete
Arrive 08:00 · Depart 18:00
The largest city on Crete and the island's main port, in Greece. A Venetian harbour and fortress front the town, while the Bronze Age palace of Knossos and the Heraklion Archaeological Museum's Minoan treasures lie close by.
- Palace of Knossos
- Venetian harbour
- Archaeological Museum
- Day9
Marmaris
Arrive 08:00 · Depart 18:00
- Day10At sea
- Day11
Izmir
Arrive 08:00 · Depart 18:00
- Day12
Istanbul
Arrive 14:00 · Depart 14:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day13
Istanbul
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
Upcoming departures
- 22 May 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Mediterranean Cruise from Istanbul FAQ
Which ports does this cruise visit?
This 12-night Mediterranean cruise calls at Istanbul, Kavala, Thessaloníki, Skíathos, Piraeus, Mykonos, Heraklion (Iraklion), Crete, Marmaris and Izmir.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Istanbul.
How long is this cruise?
12 nights aboard Seven Seas Splendor.
When does this itinerary sail?
Upcoming departures include 22 May 2026. A NestCruise advisor can confirm current availability.