

Cruise itinerary
14-Night Europe Cruise from Piraeus
14 nights · Europe · 15 ports of call
14-night Europe cruise aboard Seven Seas Prestige, departing Piraeus and calling at Mykonos, Kusadasi, Santorini, Cruising the Ionian Sea, Messina and Sorrento and 8 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Europe · Southern Europe · Mediterranean · Greek Islands · Aegean
- Departs
- Piraeus
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Prestige sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Piraeus
Arrive 05:30 · Depart 16:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2

Mykonos
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day3

Kusadasi
Arrive 08:00 · Depart 18:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day4

Santorini
Arrive 08:00 · Depart 20:00
The crescent rim of a flooded volcanic caldera in the Greek Cyclades, its whitewashed villages strung along cliffs high above the sea. Fira and Oia draw crowds for sunset views, while the caldera's dark beaches and the ancient site of Akrotiri lie below.
- Oia sunset
- Fira town
- Caldera cliffs
- Day5
Cruising the Ionian Sea
- Day6

Messina
Arrive 08:00 · Depart 17:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day7

Sorrento
Arrive 08:00 · Depart 18:00
A clifftop town on Italy's Bay of Naples, perched above the sea facing Vesuvius. Sorrento is known for its lemon groves and limoncello, a tangle of narrow shopping lanes, and its role as a base for Capri, Pompeii, and the Amalfi Coast.
- Marina Grande
- Lemon groves
- Piazza Tasso
- Day8

Civitavecchia
Arrive 07:00 · Depart 16:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day9

Livorno
Arrive 07:00 · Depart 19:00
A Tuscan port on the Ligurian Sea and the gateway to Florence and Pisa. Ships dock here for excursions to Renaissance galleries and the Leaning Tower, while Livorno itself is known for its canal district and a seafood stew called cacciucco.
- Gateway to Florence
- Pisa excursions
- Venezia Nuova canals
- Day10

Villefranche-sur-Mer
Arrive 08:00 · Depart 20:00
A deep-water bay on the French Riviera between Nice and Monaco, framed by steep pastel hillsides. The sheltered harbour is a classic tender anchorage, with a baroque old town behind the waterfront and easy connections along the coast to Nice and Monte Carlo.
- Old town
- Riviera coast
- Nice & Monaco access
- Day11

Saint-Tropez
Arrive 07:00 · Depart 19:00
A storied yachting resort on the French Riviera, its pastel old port lined with cafés and superyachts. Once a fishing village, it keeps a citadel above the harbour and is famed for the sandy beaches at nearby Pampelonne along the Côte d'Azur.
- Old port
- Pampelonne beach
- Citadel
- Day12
Cruising the Mediterranean Sea
- Day13

Cannes
Arrive 08:00 · Depart 17:00
A glamorous resort town on the French Riviera, famous for its film festival and the palm-lined seafront promenade of La Croisette. The old quarter of Le Suquet climbs above the harbour, and Antibes and Grasse lie within easy reach along the coast.
- La Croisette
- Le Suquet
- Film festival
- Day14

Palma de Mallorca
Arrive 13:00 · Depart 20:00
The capital of Mallorca in Spain's Balearic Islands, set around a wide bay. Its enormous seafront cathedral, La Seu, rises above the old town's narrow lanes, with a hilltop castle, marina and nearby coves a short way from the cruise terminal.
- La Seu cathedral
- Bellver Castle
- Old town
- Day15

Barcelona
Arrive 07:00 · Depart 16:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 23 Sep 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Europe Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 14-night Europe cruise calls at Piraeus, Mykonos, Kusadasi, Santorini, Cruising the Ionian Sea, Messina, Sorrento, Civitavecchia, Livorno, Villefranche-sur-Mer, Saint-Tropez, Cruising the Mediterranean Sea, Cannes, Palma de Mallorca and Barcelona.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus and ends in Barcelona.
How long is this cruise?
14 nights aboard Seven Seas Prestige.
When does this itinerary sail?
Upcoming departures include 23 Sep 2027. A NestCruise advisor can confirm current availability.