Cruise itinerary
14-Night Europe Cruise from Istanbul
14 nights · Europe · 12 ports of call
14-night Europe cruise aboard Seven Seas Navigator, departing Istanbul and calling at Cruising the Aegean Sea, Izmir, Mykonos, Piraeus, Heraklion (Iraklion), Crete and Cruising the Mediterranean Sea and 5 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Europe · Southern Europe · Mediterranean
- Departs
- Istanbul
- Returns
- Civitavecchia
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Navigator sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Istanbul
Depart 17:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day2
Cruising the Aegean Sea
- Day3
Izmir
Arrive 08:00 · Depart 18:00
- Day4
Mykonos
Arrive 08:00 · Depart 17:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day5
Piraeus
Arrive 05:30 · Depart 18:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day6
Heraklion (Iraklion), Crete
Arrive 08:00 · Depart 17:00
The largest city on Crete and the island's main port, in Greece. A Venetian harbour and fortress front the town, while the Bronze Age palace of Knossos and the Heraklion Archaeological Museum's Minoan treasures lie close by.
- Palace of Knossos
- Venetian harbour
- Archaeological Museum
- Day7
Cruising the Mediterranean Sea
- Day8
Alexandria
Arrive 05:00
Egypt's great Mediterranean port, founded by Alexander the Great. Once home to the ancient Lighthouse and Library, it keeps a long seafront corniche, the Qaitbay citadel on the old harbour and the modern Bibliotheca Alexandrina library.
- Qaitbay Citadel
- Bibliotheca Alexandrina
- Corniche seafront
- Day9
Alexandria
Depart 22:00
Egypt's great Mediterranean port, founded by Alexander the Great. Once home to the ancient Lighthouse and Library, it keeps a long seafront corniche, the Qaitbay citadel on the old harbour and the modern Bibliotheca Alexandrina library.
- Qaitbay Citadel
- Bibliotheca Alexandrina
- Corniche seafront
- Day10
Cruising the Mediterranean Sea
- Day11
Cruising the Mediterranean Sea
- Day12
Valletta
Arrive 08:00 · Depart 17:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day13
Messina
Arrive 08:00 · Depart 17:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day14
Salerno
Arrive 08:00 · Depart 17:00
An Italian port at the head of its own gulf, just south of the Amalfi Coast. Its long seafront and walkable medieval centre make it a quieter base for reaching Pompeii, Paestum's Greek temples and the cliffside towns of Amalfi and Positano.
- Amalfi Coast gateway
- Paestum temples
- Seafront promenade
- Day15
Civitavecchia
Arrive 07:00 · Depart 16:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
Upcoming departures
- 2 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Europe Cruise from Istanbul FAQ
Which ports does this cruise visit?
This 14-night Europe cruise calls at Istanbul, Cruising the Aegean Sea, Izmir, Mykonos, Piraeus, Heraklion (Iraklion), Crete, Cruising the Mediterranean Sea, Alexandria, Valletta, Messina, Salerno and Civitavecchia.
How many days are spent at sea?
4 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Istanbul and ends in Civitavecchia.
How long is this cruise?
14 nights aboard Seven Seas Navigator.
When does this itinerary sail?
Upcoming departures include 2 Oct 2026. A NestCruise advisor can confirm current availability.