Cruise itinerary
22-Night Caribbean Cruise from Miami, Florida
22 nights · Caribbean · 9 ports of call
22-night Caribbean cruise aboard Seven Seas Mariner, departing Miami, Florida and calling at Bridgetown, Port-of-Spain, Santarém, Boca da Valeria, Manaus and Parintins and 2 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 22 nights
- Region
- Caribbean
- Departs
- Miami, Florida
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Mariner sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2At sea
- Day3At sea
- Day4At sea
- Day5
Bridgetown
Arrive 09:00 · Depart 17:00
The capital of Barbados on the island's southwest coast, a long-standing Caribbean cruise port. Its colonial centre and Garrison Savannah are UNESCO-listed, with the white sand of Carlisle Bay and turtle-filled waters close to the harbour.
- Carlisle Bay
- Garrison Savannah
- Rum distilleries
- Day6
Port-of-Spain
Arrive 07:00 · Depart 16:00
- Day7At sea
- Day8At sea
- Day9At sea
- Day10
Santarém
Arrive 09:00 · Depart 18:00
- Day11
Boca da Valeria
Arrive 07:00 · Depart 15:00
- Day12
Manaus
Arrive 09:00 · Depart 17:00
The largest city of the Brazilian Amazon, rising deep in the rainforest where the dark Rio Negro meets the sandy Solimões. Grown rich on the rubber boom, it is known for its opulent opera house and as the gateway to jungle lodges and the Meeting of the Waters.
- Amazonas Opera House
- Meeting of the Waters
- Adolpho Lisboa Market
- Day13
Parintins
Arrive 11:00 · Depart 19:00
- Day14
Santarém
Arrive 07:00 · Depart 15:00
- Day15At sea
- Day16At sea
- Day17At sea
- Day18
St George's, Grenada
Arrive 11:30 · Depart 20:30
- Day19At sea
- Day20
San Juan
Arrive 07:00 · Depart 20:00
The capital of Puerto Rico and a major Caribbean cruise homeport. The walled colonial quarter of Old San Juan keeps blue-cobbled streets, pastel facades and two Spanish fortresses, El Morro and San Cristóbal, guarding the harbour mouth.
- Old San Juan
- El Morro
- Castillo San Cristóbal
- Day21At sea
- Day22At sea
- Day23
Miami, Florida
Arrive 06:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 9 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
22-Night Caribbean Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 22-night Caribbean cruise calls at Miami, Florida, Bridgetown, Port-of-Spain, Santarém, Boca da Valeria, Manaus, Parintins, St George's, Grenada and San Juan.
How many days are spent at sea?
12 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Miami, Florida.
How long is this cruise?
22 nights aboard Seven Seas Mariner.
When does this itinerary sail?
Upcoming departures include 9 Nov 2026. A NestCruise advisor can confirm current availability.