Cruise itinerary
14-Night Mediterranean Cruise from Piraeus
14 nights · Mediterranean · 13 ports of call
14-night Mediterranean cruise aboard Seven Seas Mariner, departing Piraeus and calling at Mykonos, Bozcaada, Istanbul, Lesbos, Kusadasi and Valletta and 6 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Mediterranean
- Departs
- Piraeus
- Returns
- Barcelona
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Mariner sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus
Depart 19:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2
Mykonos
Arrive 08:00 · Depart 18:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day3
Bozcaada
Arrive 08:00 · Depart 18:00
- Day4
Istanbul
Arrive 08:00 · Depart 18:00
The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
- Hagia Sophia
- Blue Mosque
- Grand Bazaar
- Day5
Lesbos
Arrive 10:00 · Depart 18:00
- Day6
Kusadasi
Arrive 08:00 · Depart 18:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day7At sea
- Day8
Valletta
Arrive 11:00 · Depart 20:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day9
Messina
Arrive 08:00 · Depart 18:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day10
Sorrento
Arrive 07:00 · Depart 18:00
A clifftop town on Italy's Bay of Naples, perched above the sea facing Vesuvius. Sorrento is known for its lemon groves and limoncello, a tangle of narrow shopping lanes, and its role as a base for Capri, Pompeii, and the Amalfi Coast.
- Marina Grande
- Lemon groves
- Piazza Tasso
- Day11
Civitavecchia
Arrive 07:00 · Depart 19:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day12
La Spezia
Arrive 08:00 · Depart 20:00
A port at the head of a gulf on Italy's Ligurian coast, the gateway to the Cinque Terre and Tuscany. La Spezia is known for its naval harbour and waterfront gardens, with the five cliffside fishing villages and the marble city of Carrara nearby.
- Cinque Terre
- Portovenere
- Carrara marble
- Day13
Monte-Carlo
Arrive 08:00 · Depart 20:00
The seafront quarter of Monaco on the French Riviera, set on a rocky terrace above the Mediterranean. It is known for the belle-époque Casino, the Hôtel de Paris and the harbour that hosts the Monaco Grand Prix each spring.
- Casino de Monte-Carlo
- Port Hercule
- Grand Prix circuit
- Day14At sea
- Day15
Barcelona
Arrive 06:00
Catalonia's seafront capital and one of the Mediterranean's busiest cruise homeports. Gaudí's Sagrada Família and Park Güell crown the city, while the tree-lined Ramblas and the Gothic Quarter's medieval lanes lie a short ride from the terminal.
- Sagrada Família
- La Rambla
- Gothic Quarter
Upcoming departures
- 12 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Mediterranean Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 14-night Mediterranean cruise calls at Piraeus, Mykonos, Bozcaada, Istanbul, Lesbos, Kusadasi, Valletta, Messina, Sorrento, Civitavecchia, La Spezia, Monte-Carlo and Barcelona.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus and ends in Barcelona.
How long is this cruise?
14 nights aboard Seven Seas Mariner.
When does this itinerary sail?
Upcoming departures include 12 Oct 2026. A NestCruise advisor can confirm current availability.