Cruise itinerary
21-Night Mediterranean Cruise from Piraeus
21 nights · Mediterranean · 14 ports of call
21-night Mediterranean cruise aboard Seven Seas Grandeur, departing Piraeus and calling at Mykonos, Katakolon, Cruising the Mediterranean Sea, Valletta, Messina and Naples and 7 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 21 nights
- Region
- Mediterranean · Transatlantic
- Departs
- Piraeus
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Piraeus
Arrive 05:30 · Depart 18:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
- Day2
Mykonos
Arrive 08:00 · Depart 16:00
A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
- Windmills
- Little Venice
- Chora town
- Day3
Katakolon
Arrive 09:00 · Depart 19:00
A small port on Greece's western Peloponnese coast, best known as the gateway to ancient Olympia. The sanctuary where the original Olympic Games were held lies a short drive inland, among ruined temples and the old stadium.
- Ancient Olympia
- Olympic stadium
- Temple of Zeus
- Day4
Cruising the Mediterranean Sea
- Day5
Valletta
Arrive 08:00 · Depart 18:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day6
Messina
Arrive 08:00 · Depart 18:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day7
Naples
Arrive 08:00 · Depart 18:00
A southern Italian port on its namesake bay, in the shadow of Mount Vesuvius. Ships dock near the historic centre, the gateway to Pompeii, the cliffs of the Amalfi Coast and the island of Capri, in a city that claims to have invented pizza.
- Mount Vesuvius
- Pompeii
- Gateway to Capri
- Day8
Civitavecchia
Arrive 06:00 · Depart 17:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day9
Cruising the Mediterranean Sea
- Day10
Palma de Mallorca
Arrive 08:00 · Depart 16:00
The capital of Mallorca in Spain's Balearic Islands, set around a wide bay. Its enormous seafront cathedral, La Seu, rises above the old town's narrow lanes, with a hilltop castle, marina and nearby coves a short way from the cruise terminal.
- La Seu cathedral
- Bellver Castle
- Old town
- Day11
Cruising the Strait of Gibraltar
- Day12
Sailing the Atlantic Ocean
- Day13
Funchal, Madeira
Arrive 09:00 · Depart 16:00
The capital of Madeira, a Portuguese island in the Atlantic, built up an amphitheatre of green hills above its harbour. A cable car rises to Monte, where wicker toboggans slide back down, and the island is known for its fortified wine and mountain levada walks.
- Monte cable car
- Toboggan ride
- Madeira wine
- Day14
Sailing the Atlantic Ocean
- Day15
Sailing the Atlantic Ocean
- Day16
Sailing the Atlantic Ocean
- Day17
Sailing the Atlantic Ocean
- Day18
Sailing the Atlantic Ocean
- Day19
Kings Wharf
Arrive 09:00 · Depart 15:00
The cruise port at the western tip of Bermuda, set within the historic Royal Naval Dockyard. Kings Wharf is known for the old fortress turned shopping arcade, the National Museum of Bermuda, and ferries across the sound to Hamilton and the pink beaches.
- Royal Naval Dockyard
- National Museum
- Horseshoe Bay
- Day20
Sailing the Atlantic Ocean
- Day21
Sailing the Atlantic Ocean
- Day22
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 1 Nov 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
21-Night Mediterranean Cruise from Piraeus FAQ
Which ports does this cruise visit?
This 21-night Mediterranean cruise calls at Piraeus, Mykonos, Katakolon, Cruising the Mediterranean Sea, Valletta, Messina, Naples, Civitavecchia, Palma de Mallorca, Cruising the Strait of Gibraltar, Sailing the Atlantic Ocean, Funchal, Madeira, Kings Wharf and Miami, Florida.
How many days are spent at sea?
3 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Piraeus and ends in Miami, Florida.
How long is this cruise?
21 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 1 Nov 2026. A NestCruise advisor can confirm current availability.