

Cruise itinerary
16-Night Europe Cruise from Civitavecchia
16 nights · Europe · 17 ports of call
16-night Europe cruise aboard Seven Seas Grandeur, departing Civitavecchia and calling at Naples, Messina, Valletta, Cruising the Ionian Sea, Split and Koper and 10 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 16 nights
- Region
- Europe · Southern Europe · Mediterranean
- Departs
- Civitavecchia
- Returns
- Piraeus
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1

Civitavecchia
Arrive 07:00 · Depart 17:00
The deep-water port serving Rome, roughly 80 kilometres up the coast. Ships dock here for shore excursions to the Colosseum, the Vatican and the Roman Forum, while the town itself keeps a working harbour and a Michelangelo-designed fortress.
- Gateway to Rome
- Fort Michelangelo
- Vatican excursions
- Day2

Naples
Arrive 07:00 · Depart 17:00
A southern Italian port on its namesake bay, in the shadow of Mount Vesuvius. Ships dock near the historic centre, the gateway to Pompeii, the cliffs of the Amalfi Coast and the island of Capri, in a city that claims to have invented pizza.
- Mount Vesuvius
- Pompeii
- Gateway to Capri
- Day3

Messina
Arrive 07:00 · Depart 17:00
A Sicilian port on the strait that separates the island from mainland Italy, framed by the Peloritani mountains. Its harbour clock tower performs an elaborate noon display, and the town is a common gateway to Taormina and the slopes of Mount Etna.
- Etna day trips
- Taormina gateway
- Astronomical clock
- Day4

Valletta
Arrive 07:00 · Depart 17:00
Malta's fortified harbour capital, built by the Knights of St. John on a peninsula between two deep ports. Honey-coloured limestone defines St. John's Co-Cathedral, the Grand Master's Palace and the bastions overlooking the Grand Harbour.
- Grand Harbour
- St. John's Co-Cathedral
- Upper Barrakka Gardens
- Day5
Cruising the Ionian Sea
- Day6

Split
Arrive 07:00 · Depart 16:00
A Croatian port on the Dalmatian coast, built quite literally inside the walls of a Roman emperor's retirement palace. Diocletian's Palace still forms the living old town, its cellars and courtyards woven through with cafes, shops and the cathedral.
- Diocletian's Palace
- Riva promenade
- Marjan Hill
- Day7

Koper
Arrive 09:00 · Depart 19:00
Slovenia's main port, a compact medieval town on the Adriatic with strong Venetian roots. Its Tito Square and bell tower recall centuries under Venice, and it sits within easy reach of Ljubljana, the Postojna caves and the Istrian coast.
- Tito Square
- Venetian old town
- Postojna Cave
- Day8

Fusina
Arrive 07:00 · Depart 17:00
A mainland port on the Venetian Lagoon in northeast Italy, used as the cruise gateway to Venice. A short water crossing reaches St. Mark's Square, the Grand Canal and the maze of bridges that make up the historic island city.
- Gateway to Venice
- St. Mark's Square
- Grand Canal
- Day9

Rijeka
Arrive 07:00 · Depart 17:00
Croatia's principal seaport, set where a river valley meets the Kvarner Gulf on the northern Adriatic. A working harbour city with a grand Habsburg-era core, it is crowned by the hilltop Trsat Castle and serves as a gateway to the nearby island of Krk.
- Trsat Castle
- Korzo promenade
- Kvarner Gulf
- Day10
Adriatic Sea
- Day11
Igoumenítsa
Arrive 11:00 · Depart 19:00
- Day12

Katakolon
Arrive 08:00 · Depart 18:00
A small port on Greece's western Peloponnese coast, best known as the gateway to ancient Olympia. The sanctuary where the original Olympic Games were held lies a short drive inland, among ruined temples and the old stadium.
- Ancient Olympia
- Olympic stadium
- Temple of Zeus
- Day13

Gythio
Arrive 07:00 · Depart 17:00
A coastal town in the southern Peloponnese of Greece, set on the Laconian Gulf below the Taygetos mountains. A causeway leads to the islet of Cranae, and the abandoned Byzantine hill city of Mystras lies inland near ancient Sparta.
- Cranae islet
- Mystras
- Mani peninsula
- Day14
Cruising the Aegean Sea
- Day15

Kusadasi
Arrive 07:00 · Depart 17:00
A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
- Ephesus ruins
- Library of Celsus
- Pigeon Island
- Day16

Milos
Arrive 07:00 · Depart 17:00
A volcanic island in the Greek Cyclades, ringed by some of the most unusual coastline in the Aegean. The white cliffs and sea caves of Sarakiniko, the fishing village of Klima and the bay of Adamas draw visitors ashore.
- Sarakiniko cliffs
- Klima village
- Adamas harbour
- Day17

Piraeus
Arrive 07:00 · Depart 17:00
The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
- Gateway to Athens
- Acropolis
- Aegean ferries
Upcoming departures
- 1 Aug 2028
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
16-Night Europe Cruise from Civitavecchia FAQ
Which ports does this cruise visit?
This 16-night Europe cruise calls at Civitavecchia, Naples, Messina, Valletta, Cruising the Ionian Sea, Split, Koper, Fusina, Rijeka, Adriatic Sea, Igoumenítsa, Katakolon, Gythio, Cruising the Aegean Sea, Kusadasi, Milos and Piraeus.
How many days are spent at sea?
2 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Civitavecchia and ends in Piraeus.
How long is this cruise?
16 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 1 Aug 2028. A NestCruise advisor can confirm current availability.