Cruise itinerary
14-Night Americas Cruise from Miami, Florida
14 nights · Americas · 13 ports of call
14-night Americas cruise aboard Seven Seas Grandeur, departing Miami, Florida and calling at Key West, Florida, Cruising the Florida Straits, Cozumel, Santo Tomás de Castilla, Harvest Caye and Roatán Island and 6 more.
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At a glance
- Cruise line
- Regent Seven Seas Cruises
- Duration
- 14 nights
- Region
- Americas · South America · Panama Canal
- Departs
- Miami, Florida
- Returns
- Miami, Florida
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seven Seas Grandeur sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
- Day2
Key West, Florida
Arrive 08:00 · Depart 16:00
The southernmost city in the continental United States, an island town at the end of the Florida Keys. Pastel conch houses line Duval Street, Ernest Hemingway's home is a landmark, and crowds gather at Mallory Square for the nightly sunset.
- Duval Street
- Hemingway House
- Mallory Square sunset
- Day3
Cruising the Florida Straits
- Day4
Cozumel
Arrive 07:00 · Depart 15:00
An island off Mexico's Yucatán coast in the Caribbean, a leading port for snorkelling and diving. Ships dock beside its reefs, part of the Mesoamerican system, with beach clubs, Mayan ruins and the resort strip of the Riviera Maya within reach.
- Coral reefs
- Mayan ruins
- Beach clubs
- Day5
Santo Tomás de Castilla
Arrive 11:00 · Depart 18:00
- Day6
Harvest Caye
Arrive 08:00 · Depart 17:00
- Day7
Roatán Island
Arrive 07:00 · Depart 16:00
An island off the northern coast of Honduras in the western Caribbean, part of the Bay Islands. Roatán is known for the Mesoamerican Barrier Reef just offshore, the dive sites and beaches around West End and West Bay, and forested inland hills.
- West Bay Beach
- Barrier reef diving
- West End
- Day8
Cruising the Caribbean Sea
- Day9
Puerto Limón
Arrive 08:00 · Depart 17:00
A Caribbean port on Costa Rica's humid eastern coast, the country's main Atlantic harbour. It opens onto rainforest, banana plantations and the canals of Tortuguero, with white-faced monkeys and sloths a frequent sight on excursions inland.
- Tortuguero canals
- Rainforest wildlife
- Banana country
- Day10
Gatun Lake
Arrive 07:00 · Depart 15:00
Colón
Arrive 17:00 · Depart 20:00
A Caribbean port at the Atlantic entrance to the Panama Canal, the usual landing for ships transiting or calling at the isthmus. The historic Gatún Locks and rainforest waterways lie close by, along with the duty-free trade zone and the old fortifications of Portobelo.
- Gatún Locks
- Panama Canal
- Portobelo forts
- Day11
Cruising the Caribbean Sea
- Day12
Falmouth
Arrive 08:00 · Depart 17:00
A restored Georgian port town on Jamaica's north coast, purpose-built for large cruise ships. Streets of 18th-century merchant houses sit just beyond the pier, with Montego Bay's beaches and the Martha Brae's bamboo-raft river a short drive west.
- Georgian streets
- Martha Brae rafting
- Montego Bay
- Day13
Georgetown, Grand Cayman
Arrive 09:00 · Depart 16:00
Grand Cayman's capital and the main port of the Cayman Islands, set on the calm western shore. Cruise ships tender into the harbour beside Seven Mile Beach, with Stingray City sandbars and Caribbean reef diving a short boat ride away.
- Seven Mile Beach
- Stingray City
- Seven Mile reefs
- Day14
Cruising the Florida Straits
- Day15
Miami, Florida
Arrive 07:00 · Depart 17:00
The cruise capital of the world — Miami sends more ships to sea than any port on earth. Most sailings board mid-afternoon, leaving the morning for South Beach, Little Havana or the Wynwood murals before you cast off.
- South Beach
- Little Havana
- Wynwood murals
Upcoming departures
- 22 Dec 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
14-Night Americas Cruise from Miami, Florida FAQ
Which ports does this cruise visit?
This 14-night Americas cruise calls at Miami, Florida, Key West, Florida, Cruising the Florida Straits, Cozumel, Santo Tomás de Castilla, Harvest Caye, Roatán Island, Cruising the Caribbean Sea, Puerto Limón, Gatun Lake, Colón, Falmouth and Georgetown, Grand Cayman.
How many days are spent at sea?
4 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It is a round-trip sailing from Miami, Florida.
How long is this cruise?
14 nights aboard Seven Seas Grandeur.
When does this itinerary sail?
Upcoming departures include 22 Dec 2027. A NestCruise advisor can confirm current availability.