Seabourn Quest — 21-Night Mediterranean Cruise from Piraeus

Cruise itinerary

21-Night Mediterranean Cruise from Piraeus

21 nights · Mediterranean · 17 ports of call

21-night Mediterranean cruise aboard Seabourn Quest, departing Piraeus and calling at Gythion, Soúda, Crete, Mykonos, Çesme, Kusadasi and Istanbul and 10 more.

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At a glance

Ship: Seabourn Quest
Cruise line: Seabourn
Duration: 21 nights
Region: Mediterranean
Departs: Piraeus
Returns: Venice

How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Seabourn Quest sailing, typically within 24 hours.

Where this voyage takes you

Voyage route — calls shown in order; map is schematic.

Day-by-day itinerary

Day
1
- Piraeus
  Depart 17:00
  The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
  - Gateway to Athens
  - Acropolis
  - Aegean ferries
Day
2
- Gythion
  Arrive 08:00 · Depart 17:00
Day
3
- Soúda, Crete
  Arrive 08:00 · Depart 17:00
  The port of Chania on the northwest coast of Crete, set beside Souda Bay, one of the Mediterranean's deepest natural harbours. It opens onto the old Venetian quarter of Chania, with its lighthouse, harbour-front, and lanes of the former Turkish town.
  - Chania old town
  - Venetian lighthouse
  - Souda Bay
Day
4
- Mykonos
  Arrive 08:00 · Depart 18:00
  A Cycladic island in the Aegean known for whitewashed houses and a lively summer scene. Ships anchor off the main town, where windmills overlook the sea, the Little Venice quarter meets the waves and sandy beaches stretch along the south coast.
  - Windmills
  - Little Venice
  - Chora town
Day
5
- Çesme
  Arrive 08:00 · Depart 18:00
Day
6
- Kusadasi
  Arrive 08:00 · Depart 23:00
  A resort town on Turkey's Aegean coast that serves as the cruise gateway to ancient Ephesus, one of the best-preserved classical cities in the Mediterranean. Pigeon Island guards the harbour, and the marble Library of Celsus lies a short drive inland.
  - Ephesus ruins
  - Library of Celsus
  - Pigeon Island
Day
7
At sea
Day
8
- Istanbul
  Arrive 07:00 · Depart 17:00
  The city straddling Europe and Asia along the Bosphorus, once Byzantium and then Constantinople. Ships dock near the historic peninsula, within reach of the Hagia Sophia, the Blue Mosque and the covered Grand Bazaar's labyrinth of stalls.
  - Hagia Sophia
  - Blue Mosque
  - Grand Bazaar
Day
9
- Çanakkale
  Arrive 08:00 · Depart 18:00
  A Turkish port at the narrowest point of the Dardanelles strait, between the Aegean and the Sea of Marmara. It is the gateway to the ruins of ancient Troy and to the Gallipoli battlefields and war memorials across the water on the peninsula.
  - Ancient Troy
  - Gallipoli battlefields
  - Dardanelles strait
Day
10
- Izmir
  Arrive 08:00 · Depart 18:00
Day
11
- Pátmos
  Arrive 08:00 · Depart 17:00
  A small Greek island in the Dodecanese, long held sacred in Christian tradition. The hilltop Monastery of Saint John crowns the whitewashed Chóra, near the cave where the Book of Revelation is said to have been written above the harbour at Skala.
  - Monastery of St. John
  - Cave of the Apocalypse
  - Chóra hilltop
Day
12
- Rhodes
  Arrive 08:00 · Depart 23:00
  The largest of Greece's Dodecanese islands, off the Turkish coast, with one of Europe's best-preserved medieval walled towns. The Old Town keeps the cobbled Street of the Knights and the Palace of the Grand Master, while Lindos and its acropolis lie down the coast.
  - Medieval Old Town
  - Palace of the Grand Master
  - Lindos Acropolis
Day
13
At sea
Day
14
- Spetses
  Arrive 08:00 · Depart 17:00
Day
15
- Piraeus
  Arrive 07:00 · Depart 17:00
  The ancient harbour of Athens and Greece's principal cruise port. Ferries fan out to the Aegean islands from its quays, while the Acropolis, the Plaka district and the National Archaeological Museum sit a short metro ride inland.
  - Gateway to Athens
  - Acropolis
  - Aegean ferries
Day
16
- Gythion
  Arrive 08:00 · Depart 17:00
Day
17
At sea
Day
18
- Dubrovnik
  Arrive 08:00 · Depart 22:00
  A walled city on Croatia's Dalmatian coast, its limestone old town wrapped in sea-facing ramparts above the Adriatic. Ships call here for the marble main street of Stradun, the circuit of the city walls and the cable car to Mount Srđ.
  - City walls
  - Stradun
  - Mount Srđ cable car
Day
19
- Hvar Island Croatia
  Arrive 08:00 · Depart 18:00
Day
20
- Zadar
  Arrive 08:00 · Depart 18:00
  A walled Adriatic city on Croatia's Dalmatian coast, built on a compact peninsula of Roman and Venetian stone. Zadar is known for its waterfront Sea Organ, the solar Greeting to the Sun installation, and Roman ruins at the old forum.
  - Sea Organ
  - Roman Forum
  - Greeting to the Sun
Day
21
- Koper
  Arrive 08:00 · Depart 18:00
  Slovenia's main port, a compact medieval town on the Adriatic with strong Venetian roots. Its Tito Square and bell tower recall centuries under Venice, and it sits within easy reach of Ljubljana, the Postojna caves and the Istrian coast.
  - Tito Square
  - Venetian old town
  - Postojna Cave
Day
22
- Venice
  Arrive 07:00
  A city built across more than a hundred islands in a lagoon on the Adriatic, threaded by canals instead of streets. Venice is known for St. Mark's Basilica and its piazza, the Grand Canal and Rialto Bridge, and the glass workshops of Murano nearby.
  - St. Mark's Square
  - Grand Canal
  - Rialto Bridge

Upcoming departures

21 Jun 2026
16 Aug 2026

Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.

21-Night Mediterranean Cruise from Piraeus FAQ

Which ports does this cruise visit?

This 21-night Mediterranean cruise calls at Piraeus, Gythion, Soúda, Crete, Mykonos, Çesme, Kusadasi, Istanbul, Çanakkale, Izmir, Pátmos, Rhodes, Spetses, Dubrovnik, Hvar Island Croatia, Zadar, Koper and Venice.

How many days are spent at sea?

3 days are spent at sea; the rest are in port.

Where does this cruise depart from?

It departs from Piraeus and ends in Venice.

How long is this cruise?

21 nights aboard Seabourn Quest.

When does this itinerary sail?

Upcoming departures include 21 Jun 2026 and 16 Aug 2026. A NestCruise advisor can confirm current availability.

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