Cruise itinerary
12-Night Asia Cruise from Siem Reap
12 nights · Asia · 11 ports of call
12-night Asia cruise aboard Scenic Spirit, departing Siem Reap and calling at Mekong River Vietnam/Cambodia, Kampong Cham, Angkor Ban, Koh Dach Island, Phnom Penh, Phnom Penh and Border Crossing and 4 more.
- Free advisor
- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Scenic Spirit
- Cruise line
- Scenic
- Duration
- 12 nights
- Region
- Asia · Mekong
- Departs
- Siem Reap
- Returns
- Ho Chi Minh City
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Scenic Spirit sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Siem Reap
The Cambodian town that serves as gateway to the temples of Angkor, the vast Khmer complex set in jungle to the north. Angkor Wat and the stone faces of the Bayon draw visitors, while the town itself centres on river markets and Pub Street.
- Angkor Wat
- Bayon faces
- Ta Prohm
- Day2
Siem Reap
The Cambodian town that serves as gateway to the temples of Angkor, the vast Khmer complex set in jungle to the north. Angkor Wat and the stone faces of the Bayon draw visitors, while the town itself centres on river markets and Pub Street.
- Angkor Wat
- Bayon faces
- Ta Prohm
- Day3
Siem Reap
The Cambodian town that serves as gateway to the temples of Angkor, the vast Khmer complex set in jungle to the north. Angkor Wat and the stone faces of the Bayon draw visitors, while the town itself centres on river markets and Pub Street.
- Angkor Wat
- Bayon faces
- Ta Prohm
- Day4
Siem Reap
The Cambodian town that serves as gateway to the temples of Angkor, the vast Khmer complex set in jungle to the north. Angkor Wat and the stone faces of the Bayon draw visitors, while the town itself centres on river markets and Pub Street.
- Angkor Wat
- Bayon faces
- Ta Prohm
Mekong River Vietnam/Cambodia
- Day5
Kampong Cham
A riverside provincial town on the Mekong in eastern Cambodia, long a trading and rubber-growing hub. Nearby stand the hilltop temples of Phnom Pros and Phnom Srei and the early Angkorian shrine of Wat Nokor.
- Wat Nokor
- Bamboo bridge
- Mekong riverfront
Kampong Cham
A riverside provincial town on the Mekong in eastern Cambodia, long a trading and rubber-growing hub. Nearby stand the hilltop temples of Phnom Pros and Phnom Srei and the early Angkorian shrine of Wat Nokor.
- Wat Nokor
- Bamboo bridge
- Mekong riverfront
- Day6
Angkor Ban
Koh Dach Island, Phnom Penh
Phnom Penh
Cambodia's capital, set where the Mekong and Tonlé Sap rivers meet. Once styled the Pearl of Asia, it keeps grand French-colonial avenues alongside the gilded Royal Palace, the Silver Pagoda and the sobering history of the Tuol Sleng museum.
- Royal Palace
- Silver Pagoda
- Mekong riverfront
- Day7
Phnom Penh
Cambodia's capital, set where the Mekong and Tonlé Sap rivers meet. Once styled the Pearl of Asia, it keeps grand French-colonial avenues alongside the gilded Royal Palace, the Silver Pagoda and the sobering history of the Tuol Sleng museum.
- Royal Palace
- Silver Pagoda
- Mekong riverfront
- Day8
Phnom Penh
Cambodia's capital, set where the Mekong and Tonlé Sap rivers meet. Once styled the Pearl of Asia, it keeps grand French-colonial avenues alongside the gilded Royal Palace, the Silver Pagoda and the sobering history of the Tuol Sleng museum.
- Royal Palace
- Silver Pagoda
- Mekong riverfront
Border Crossing
Tân Châu
A riverside town in An Giang Province on the Mekong Delta in southern Vietnam, near the Cambodian border. Tân Châu is known for its silk-weaving tradition, floating fish farms, and as a quiet stop on Mekong river cruises.
- Silk weaving
- Mekong fish farms
- Delta villages
- Day9
Tân Châu
A riverside town in An Giang Province on the Mekong Delta in southern Vietnam, near the Cambodian border. Tân Châu is known for its silk-weaving tradition, floating fish farms, and as a quiet stop on Mekong river cruises.
- Silk weaving
- Mekong fish farms
- Delta villages
- Day10
Sa Déc
Cái Bè
- Day11
Ho Chi Minh City
Vietnam's largest city, still widely called Saigon, set on a river in the Mekong Delta region. French-era landmarks like the Notre-Dame basilica and Central Post Office sit amid motorbike-filled streets, with the Cu Chi tunnels reachable on a day trip.
- Notre-Dame Basilica
- Ben Thanh Market
- Cu Chi Tunnels
- Day12
Ho Chi Minh City
Vietnam's largest city, still widely called Saigon, set on a river in the Mekong Delta region. French-era landmarks like the Notre-Dame basilica and Central Post Office sit amid motorbike-filled streets, with the Cu Chi tunnels reachable on a day trip.
- Notre-Dame Basilica
- Ben Thanh Market
- Cu Chi Tunnels
- Day13
Ho Chi Minh City
Vietnam's largest city, still widely called Saigon, set on a river in the Mekong Delta region. French-era landmarks like the Notre-Dame basilica and Central Post Office sit amid motorbike-filled streets, with the Cu Chi tunnels reachable on a day trip.
- Notre-Dame Basilica
- Ben Thanh Market
- Cu Chi Tunnels
Upcoming departures
- 19 Sep 2026
- 27 Sep 2026
- 3 Oct 2026
- 11 Oct 2026
- 17 Oct 2026
- 25 Oct 2026
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Asia Cruise from Siem Reap FAQ
Which ports does this cruise visit?
This 12-night Asia cruise calls at Siem Reap, Mekong River Vietnam/Cambodia, Kampong Cham, Angkor Ban, Koh Dach Island, Phnom Penh, Phnom Penh, Border Crossing, Tân Châu, Sa Déc, Cái Bè and Ho Chi Minh City.
How many days are spent at sea?
This is a port-intensive itinerary with no full days at sea.
Where does this cruise depart from?
It departs from Siem Reap and ends in Ho Chi Minh City.
How long is this cruise?
12 nights aboard Scenic Spirit.
When does this itinerary sail?
Upcoming departures include 19 Sep 2026, 27 Sep 2026, 3 Oct 2026 and 11 Oct 2026. A NestCruise advisor can confirm current availability.