Cruise itinerary
12-Night Mekong Cruise from Siem Reap
12 nights · Mekong · 8 ports of call
12-night Mekong cruise aboard Scenic Spirit, departing Siem Reap and calling at Kampong Cham, Angkor Ban, Phnom Penh, Tân Châu, Sa Déc and Cái Bè and 1 more.
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- No booking fees
- 10,000+ sailings
At a glance
- Ship
- Scenic Spirit
- Cruise line
- Scenic
- Duration
- 12 nights
- Region
- Mekong · Southeast Asia
- Departs
- Siem Reap
- Returns
- Saigon
How NestCruise works:we're advisor-led, not a booking engine. No fares are listed and there are no booking fees — tell an advisor your dates and party and they price your exact Scenic Spirit sailing, typically within 24 hours.
Where this voyage takes you
Day-by-day itinerary
- Day1
Siem Reap
The Cambodian town that serves as gateway to the temples of Angkor, the vast Khmer complex set in jungle to the north. Angkor Wat and the stone faces of the Bayon draw visitors, while the town itself centres on river markets and Pub Street.
- Angkor Wat
- Bayon faces
- Ta Prohm
- Day2At sea
- Day3At sea
- Day4At sea
- Day5
Kampong Cham
A riverside provincial town on the Mekong in eastern Cambodia, long a trading and rubber-growing hub. Nearby stand the hilltop temples of Phnom Pros and Phnom Srei and the early Angkorian shrine of Wat Nokor.
- Wat Nokor
- Bamboo bridge
- Mekong riverfront
- Day6
Angkor Ban
- Day7
Phnom Penh
Cambodia's capital, set where the Mekong and Tonlé Sap rivers meet. Once styled the Pearl of Asia, it keeps grand French-colonial avenues alongside the gilded Royal Palace, the Silver Pagoda and the sobering history of the Tuol Sleng museum.
- Royal Palace
- Silver Pagoda
- Mekong riverfront
- Day8At sea
- Day9
Tân Châu
A riverside town in An Giang Province on the Mekong Delta in southern Vietnam, near the Cambodian border. Tân Châu is known for its silk-weaving tradition, floating fish farms, and as a quiet stop on Mekong river cruises.
- Silk weaving
- Mekong fish farms
- Delta villages
- Day10At sea
- Day11
Sa Déc
- Day12
Cái Bè
- Day13
Saigon
Upcoming departures
- 27 Jul 2026
- 14 Aug 2026
- 1 Sep 2026
- 14 Dec 2026
- 26 Jul 2027
- 13 Aug 2027
- 31 Aug 2027
- 27 Nov 2027
- 15 Dec 2027
Upcoming sailings of this itinerary — a NestCruise advisor confirms current availability and your fare.
12-Night Mekong Cruise from Siem Reap FAQ
Which ports does this cruise visit?
This 12-night Mekong cruise calls at Siem Reap, Kampong Cham, Angkor Ban, Phnom Penh, Tân Châu, Sa Déc, Cái Bè and Saigon.
How many days are spent at sea?
5 days are spent at sea; the rest are in port.
Where does this cruise depart from?
It departs from Siem Reap and ends in Saigon.
How long is this cruise?
12 nights aboard Scenic Spirit.
When does this itinerary sail?
Upcoming departures include 27 Jul 2026, 14 Aug 2026, 1 Sep 2026 and 14 Dec 2026. A NestCruise advisor can confirm current availability.